With the aiming of solving problems with the existing ordinary excavator buckets used in the process of operations (such as heavy digging resistance, ease of adhesion, and others), seven types of bionic buckets and a prototype bucket were designed, based on the contractile-state curve of the earthworm head and the contour curve of the pangolin claw toe. The digging processes of the buckets were simulated using the discrete element method. The results show that, compared with the prototype buckets, all seven types of bionic buckets have significant drag reduction effects at the same digging depth, and the drag reduction effects increase with the decrease of digging speed.
View Article and Find Full Text PDFBacterial infection, reactive oxygen species (ROS) accumulation, and persistent inflammation pose significant challenges in the treatment of periodontitis. However, the current single-modal strategy makes achieving the best treatment effect difficult. Herein, we developed a double-network hydrogel composed of Pluronic F127 (PF-127) and hyaluronic acid methacrylate (HAMA) loaded with spermidine-modified mesoporous polydopamine nanoparticles (M@S NPs).
View Article and Find Full Text PDFElectrospinning is a widely recognized method for producing Janus or core-shell nanofibers. In this study, nanofibrous membranes were fabricated through co-axial electrospinning utilizing polycaprolactone (PCL) and silk fibroin (SF) as the Janus shell, and taxifolin (TAX) and SF as the core. The resulting nanofibers had diameters of 816 ± 161 nm and core diameters of 73 ± 5 nm.
View Article and Find Full Text PDFThe continuous stimulation of periodontitis leads to a decrease in the number of stem cells within the lesion area and significantly impairing their regenerative capacity. Therefore, it is crucial to promote stem cell homing and regulate the local immune microenvironment to suppress inflammation for the regeneration of periodontitis-related tissue defects. Here, we fabricated a novel multifunctional bilayer nanofibrous membrane using electrospinning technology.
View Article and Find Full Text PDFThe diagnosis of ankylosing spondylitis (AS) can be complex, necessitating a comprehensive assessment of medical history, clinical symptoms, and radiological evidence. This multidimensional approach can exacerbate the clinical burden and increase the likelihood of diagnostic inaccuracies, which may result in delayed or overlooked cases. Consequently, supplementary diagnostic techniques for AS have become a focal point in clinical research.
View Article and Find Full Text PDFLarge skin wounds are one of the most important health problems in the world. Skin wound repair and tissue regeneration are complex processes involving many physiological signals, and effective wound healing remains an enormous clinical challenge. Therefore, there is an urgent need for a strategy to rapidly kill bacteria, promote cell proliferation and accelerate wound healing.
View Article and Find Full Text PDFOsteoporotic bone defect has become clinic challenge due to its morbid bone microenvironment. Overactive bone resorption and limited bone formation lead to unstable combination between bone tissue and scaffolds. Electrospinning has been widely used in guide tissue membrane, but its barrier property results in limited application.
View Article and Find Full Text PDFIn order to study the dynamic interface mechanical behavior between soil and agricultural machinery and reveal the causes of tillage resistance, three kinds of bionic furrow opener were designed according to the characteristics of earthworm head surface curve, using the discrete element method to simulate and analyze the process of the furrow openers. The results showed that the order of ditching resistance from large to small is traditional opener, bionic corrugated opener, bionic ridgeline opener, bionic composite opener. With the same ditching speed, the drag reduction effect of the three bionic openers increases with the increase of the ditching depth.
View Article and Find Full Text PDFHypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholesterolemia is of great significance to reduce clinical cardiovascular events and patient mortality. Simvastatin (SIM) and ezetimibe (EZE) are commonly used clinically as cholesterol-lowering drugs; however, their treatment efficacy is severely affected by their poor water solubility and low bioavailability.
View Article and Find Full Text PDFPeriodontitis is a chronic inflammatory disease caused by plaque that leads to alveolar bone resorption. In the treatment of periodontitis, it is necessary to reduce the bacterial load and promote alveolar bone regeneration. In this study, zeolitic imidazolate framework-8 (ZIF-8) is used in the treatment of periodontitis, and an injectable photopolymerizable ZIF-8/gelatin methacryloyl (GelMA) composite hydrogel (GelMA-Z) is constructed.
View Article and Find Full Text PDFGuided tissue regeneration (GTR) strategies are an effective approach to repair periodontal defects by using GTR membranes. However, commercial GTR membranes still have limitations in periodontal tissue regeneration owing to lack of antibacterial and osteogenic properties. The development of novel Janus nanofibers with biphasic release characteristics based on the therapeutic needs of GTR is essential to tackle this issue.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
November 2020
is a forerunner species of wind-break and sand-fixation in desert steppe in China, which plays an important role in ecosystem restoration and reconstruction. How-ever, it could influence human health. Based on 89 valid data of current distribution of in China and 19 typical climatic factors, the MaxEnt model was used to simulate the potential distribution of in China under current and two scenarios (RCP 4.
View Article and Find Full Text PDFmiR-144-5p exhibits anti-tumor activities in various cancers. Although treatment for glioblastoma has progressed rapidly, novel targets for glioblastoma are insufficient, particularly those used in precision medicine. In the current study, we found that ginsenoside Rd reduced the proliferation and migration of glioblastoma cells.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2020
Objectives: Early diagnosis of and markers for gingival oral squamous cell carcinoma (OSCC) is important for effective treatment.
Methods: The current study performed a whole exome sequencing of gingival OSCC tissues in thirteen Chinese patients to explore exonic mutants.
Results: Eighty-five genes emerged as mutants in patients with primary gingival OSCC.
Exploiting photocatalysts with characteristics of low cost, high reactivity and good recyclability is a great significance for environmental remediation and energy conversion. Herein, hollow TiO nanotubes were fabricated by a novel and efficient method electrospinning and an impregnation calcination method. With the hydrothermal method, the CdS nanoparticles were modified on the surface and in walls of the TiO nanotubes.
View Article and Find Full Text PDFWorld J Gastroenterol
February 2020
Background: Oral squamous cell carcinoma (OSCC) ranks as the fifth most frequent cancer worldwide, and the recurrence and migration of OSCC still pose large threats to patients. Long non-coding RNAs (lncRNAs) have recently emerged as crucial players in cancer development, and it is of great significance to understand the regulatory nexus of lncRNAs in OSCC.
Methods: Here, we identified a novel lncRNA, RP11-874J12.
Exosome proteomic analysis may reveal differentially abundant proteins that are of significance for clarifying the pathogenesis of SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) syndrome. Exosomes were isolated from the serum, bone marrow and skin tissue of the palm and toe pustular areas in a unique patient with SAPHO syndrome. The exosomes were not different from those of healthy subjects in size (114.
View Article and Find Full Text PDFBackground: Esophageal cancer is one of the most poorly diagnosed and fatal cancers in the world. Although a series of studies on esophageal cancer have been reported, the molecular pathogenesis of the disease remains elusive.
Aim: To investigate comprehensively the molecular process of esophageal cancer.
Appl Bionics Biomech
October 2019
In the present study, a coupling bionic method is used to study the drag reduction characteristics of corrugated surface with lubrication. In order to test the drag reduction features, bionic specimen was prepared inspired by earthworm surface and lubrication. Based on the reverse engineering method, nonsmooth curve of earthworm surface was extracted and the bionic corrugated sample was designed, and the position of lubrication hole was established by experimental testing.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2019
Background: It's difficult to diagnose and treat synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome due to its rare and unknown pathogenesis. There is no effective treatment for SAPHO syndrome and the consequences of empirical treatment are unpredictable. This study reports a case of a young female diagnosed as SAPHO syndrome with pathological fractures of vertebral bodies.
View Article and Find Full Text PDFObjective To investigate the association between time from hospital admission to intensive care unit (ICU) admission (door to ICU time) and hospital mortality in patients with sepsis. Methods This retrospective observational study included routinely collected healthcare data from patients with sepsis. The primary endpoint was hospital mortality, defined as the survival status at hospital discharge.
View Article and Find Full Text PDFPostoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO]) and urea as the titanium source and precipitant, respectively.
View Article and Find Full Text PDFKudingcha is a particularly bitter tasting tea that has been widely used in China to eliminate fever and itching eyes, and to clear blood toxins. Kudingcha is considered of value for its potential anticancer effects that are attributed to the presence of characteristic bioactive ingredients. The chlorogenic acid (CGA) derivatives 3-0-caffeoylquinic acid, 5-0-caffeoylquinic acid, 3,5-0-dicaffeoylquinic acid, and 4,5-0-dicaffeoylquinic acid were separated from Ilex kudingcha C.
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