Recycling red mud with raw coal to low-cost Fe/C/ceramic composite for efficient microwave absorption.

To solve the urgent issue of electromagnetic (EM) wave radiation pollution and promote the resource utilisation of red mud (RM, a solid waste), Fe/C/ceramic composite EM wave-absorbing materials were constructed by recycling RM with raw coal (RC) through simple mechanical mixing and then carbothermal reduction between FeO in RM and carbon component in RC. It was found that the calcined temperature of 900 °C can be considered the optimal formation temperature for Fe. In addition, a tuneable EM wave absorption performance could be attained by regulating the mass ratio of RC to RM (denoted as :).

Causal relationship between rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and risk of prostate cancer: Multivariable and bidirectional Mendelian-randomization analyses.

Previous studies have suggested an association between autoimmune diseases (AIDs) and the risk of prostate cancer (PCa). However, the causal relationship between AID and PCa remained unclear. The purpose of this study was to investigate the causal association between 3 common AIDs, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS), and the risk of PCa.

Anxiety and Academic Procrastination in Deaf and Hard of Hearing College Students: A Moderated Mediation Model.

Deaf and hard of hearing college students encounter unique challenges and pressures in their daily lives and academic pursuits, often leading to heightened anxiety levels, which may increase the likelihood of academic procrastination. This study aims to investigate the relationship between anxiety and academic procrastination in deaf and hard of hearing college students, with a focus on the mediating role of rumination and the moderating effect of psychological resilience. The findings offer valuable insights into strategies for reducing anxiety and academic procrastination in this population.

Bibliometric and visual assessment of research trends in the management of hyperuricemia (HUA).

Objective: To analyze the development status and trend of related research in the health management of hyperuricemia and provide a theoretical basis for clinical treatment.

Methods: A bibliometric analysis was conducted on hyperuricemia health management research data from 2000 to 2024 using the Web Science Core Collection database, PubMed, and SINOMED. A total of 789 articles were evaluated for specific characteristics, such as year of publication, journal, author, institution, country/region, reference, and keyword.

The value of predicting neoadjuvant chemotherapy early efficacy in nasopharyngeal carcinoma based on amide proton transfer imaging and diffusion weighted imaging.

Background: Early detection of nasopharyngeal carcinoma (NPC) patients who are not sensitive to neoadjuvant chemotherapy (NAC) can guard against overtreatment. This study aimed to evaluate the effectiveness of amide proton transfer (APT) imaging and diffusion-weighted imaging (DWI) in predicting the early response to NAC in patients with NPC.

Methods: This prospective study enrolled fifty patients with biopsy-confirmed NPC from September 2021 to May 2023.

Efficacy and safety of low-dose interleukin 2 in the treatment of moderate-to-severe bullous pemphigoid: A single center perspective-controlled trial.

Background: Regulatory T cells (Tregs) are reduced in the peripheral blood and skin lesions of patients with bullous pemphigoid (BP). Low-dose interleukin 2 (IL-2) therapy can stimulate Tregs specifically, suggesting potential for the treatment of BP.

Objective: To evaluate the response to low-dose IL-2 therapy in the treatment of moderate-to-severe BP.

Predicting ammonia emissions and global warming potential in composting by machine learning.

The amounts of gases emitted from composting are key to evaluating global warming potential (GWP). However, few methods can accurately predict the quantities of relevant gas emissions. In this study, three developed machine-learning models were used to predict NH emissions and GWP.

The Impact of Executive Dysfunction on Anxiety in Hearing-Impaired College Students: Smartphone Addiction as a Mediator and Academic Procrastination as a Moderator.

Purpose: Hearing-impaired college students often rely on smartphones for information exchange and social interaction due to their hearing limitations, which may increase their risk of smartphone addiction. This study aims to explore the impact of executive dysfunction on anxiety levels in hearing-impaired college students, investigating smartphone addiction as a mediator and academic procrastination as a moderator.

Methods: We conducted a questionnaire survey using the Executive Function Scale, the Anxiety Scale, the Smartphone Addiction Scale, and the Academic Procrastination Scale.

Multimodal imaging evaluation of early neurological deterioration following acute ischemic stroke.

Background: Early neurologic deterioration occurs in up to one-third of patients with acute ischemic stroke (IS), often leading to poor functional outcomes. At present, few studies have applied amide proton transfer (APT) imaging to the evaluation of early neurological deterioration (END). This study analyzed the value of computed tomography perfusion (CTP) combined with multimodal magnetic resonance imaging (MRI) in patients with acute IS with END.

RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability.

TAR DNA-binding protein 43 (TDP43) is increasingly recognized for its involvement in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP43 proteinopathy, characterized by dysregulated nuclear export and cytoplasmic aggregation, is present in most ALS/FTD cases and is associated with a loss of nuclear function and genomic instability in neurons. Building on prior evidence linking TDP43 pathology to DNA double-strand breaks (DSBs), this study identifies a novel regulatory role for TDP43 in the DNA mismatch repair (MMR) pathway.

Micronized acellular dermal matrix combined with platelet rich plasma in the treatment of atrophic acne scars: A self-controlled split face study.

Background: Micronized acellular dermal matrix (mADM) can induce tissue regeneration and repair, and filling.

Objectives: The efficacy and safety of (mADM) were evaluated in the treatment of atrophic acne scar.

Methods: In this single-blinded, self-controlled, split-face study, 16 patients (48 scar sites) were divided into treatment group (24 scar sites) and control group (24 scar sites).

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin () gene. The repeat-expanded encodes a mutated HTT (mHTT), which is known to induce DNA double-strand breaks (DSBs), activation of the cGAS-STING pathway, and apoptosis in HD. However, the mechanism by which mHTT triggers these events is unknown.

Microbial production of branched chain amino acids: Advances and perspectives.

Branched-chain amino acids (BCAAs) such as L-valine, L-leucine, and L-isoleucine are widely used in food and feed. To comply with sustainable development goals, commercial production of BCAAs has been completely replaced with microbial fermentation. However, the efficient production of BCAAs by microorganisms remains a serious challenge due to their staggered metabolic networks and cell growth.

New nurses' turnover intention and clinical belonging, based on latent class analysis (LCA).

Aim: To identify potential categories of clinical belonging among new nurses and explore the relationship between different categories and turnover intention.

Design: A cross sectional study.

Method: A cross sectional study was conducted among 348 new nurses from tertiary hospitals in Hainan and Guangdong provinces.

Contribution of zeolite to nitrogen retention in chicken manure and straw compost: Reduction of NH and NO emissions and increase of nitrate.

Co-composting of chicken manure, straw and zeolite was investigated in a water bath heating system to estimate the effect of zeolite on physicochemical properties and metabolic functions related to nitrogen conversion. The results indicated that NH catches by zeolite was concentrated in the early stage and zeolite with 10 % addition reduced 28 % NH and 55 % NO emissions as compost ended. The nitrate content in 10 % zeolite group was 17 % higher than that in control group.

Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.

Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including non-coding genes. TC-NER involves lesion recognition by the initiation complex consisting of RNA polymerase II (Pol II) and Cockayne syndrome group B (CSB), followed by NER-catalyzed lesion removal. However, the efficient lesion removal requires the initiation complex to yield the right of way to the excision machinery, and how this occurs in a timely manner is unknown.

Systematic metabolic engineering of Yarrowia lipolytica for the enhanced production of erythritol.

In recent times, there has been a growing interest in exploring microbial strains that exhibit enhanced erythritol productivity. Nonetheless, the lack of advanced synthetic biology tools has limited rapid strain development. In this study, the CRISPR/Cas9 system was employed to genetically modify Yarrowia lipolytica at the chromosomal level, which could improve the production of erythritol while saving the time required to markers recovery, and realizing the rapid construction of high-erythritol strains.

The crosstalk between DNA repair and immune responses.

In recent years, increasing evidence has highlighted the profound connection between DNA damage repair and the activation of immune responses. We spoke with researchers about their mechanistic interplays and the implications for cancer and other diseases.

Janus kinase inhibitor, tofacitinib, in refractory juvenile dermatomyositis: a retrospective multi-central study in China.

Objectives: Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate. Existing research has suggested that interferon and Janus kinase played an important role in pathogenesis.

Construction of a plasmid-free L-leucine overproducing Escherichia coli strain through reprogramming of the metabolic flux.

Background: L-Leucine is a high-value amino acid with promising applications in the medicine and feed industries. However, the complex metabolic network and intracellular redox imbalance in fermentative microbes limit their efficient biosynthesis of L-leucine.

Results: In this study, we applied rational metabolic engineering and a dynamic regulation strategy to construct a plasmid-free, non-auxotrophic Escherichia coli strain that overproduces L-leucine.