Upregulation of RCN2 accelerates tumor progression and indicates poor prognosis in OSCC.

Objective: Oral squamous cell carcinoma (OSCC) is a prevalent cancer of the head and neck region. However, the potential role of RCN2 in OSCC is currently not well understood.

Study Design: A series of molecular biology experiments were conducted to explore the mechanism by which RCN2 promotes OSCC growth through protein kinase A (PKA).

The health benefits of fermented fruits and vegetables and their underlying mechanisms.

Fermented fruits and vegetables are rich in phenolic compounds, minerals, and vitamins, which have potential health benefits for the prevention of many diseases such as cardiovascular disease and Type 2 diabetes. There is a growing demand for the development of nondairy probiotic products based on fruits and vegetables in view of changing lifestyles (e.g.

Overexpression of vacuolar H-pyrophosphatase from a recretohalophyte enhances vegetative growth and salt tolerance in transgenic .

, a wild and endangered salt-secreting small shrub, is distributed in arid and semi-arid areas of Inner Mongolia, China. An H-pyrophosphatase gene () was isolated from . according to transcriptomic data, which encoded a plasma membrane and tonoplast-localized protein.

Fabric Solar Evaporator Inspired by Jellyfish for Efficient and Continuous Water Desalination.

The conversion of solar energy into heat for seawater desalination is emerging as a promising method. However, it requires further research on light absorption, thermal management, and salt deposition to improve water evaporation rates. This study introduces a 3D solar evaporator inspired by jellyfish utilizing honeycomb fabric (HF), which capitalizes on a synergistic effect between the periodically arranged concave unit structure and the Chinese ink and carbon black particles (ink@CB), achieving up to 98% light absorption with ink@CB-HF.

Effect of the Total Saponins of DC. Water Extracts Following Ultrafiltration Pretreatment on Macroporous Resin Adsorption.

Macroporous resin is an efficient separation technology that plays a crucial role in the separation and purification of traditional Chinese medicine (TCM). However, the application of macroporous resins in TCM pharmaceuticals is hindered by serious fouling caused by the complex materials used in TCM. This study examines the impact of ultrafiltration (UF) membrane technology on the macroporous resin adsorption behavior of TCM extracts.

Identification and functional analysis of the Dof transcription factor genes in sugar beet.

In this study, members of the BvDof transcription factor family were identified in the beet genome data (Beta vulgaris L.) Through systematic analysis, 22 BvDof family genes were found in the beet genome, and they were divided into nine groups by phylogenetic analysis. Fifteen members of the BvERF family were involved in the transition to rapid root tuber growth.

Influence of Water and Fertilizer Reduction on Respiratory Metabolism in Sugar Beet Taproot ( L.).

Inner Mongolia, a major region in China for growing sugar beet, faces challenges caused by unscientific water and fertilizer management. This mismanagement restricts the improvement of sugar beet yield and quality and exacerbates water waste and environmental pollution. This study aims to evaluate the effects of reduced water and fertilizer on the growth and physiological metabolism of sugar beet taproot.

Effect of different extraction methods on the lipid composition and antioxidant activity of Ziziphi spinosae semens oil.

Chinese sour jujube is an important fruit for both medicine and food and effects various biological activities. Although the Chinese sour jujube seed (Ziziphi spinosae semen) is rich in oil, its lipid profiles is significantly affected by the extraction process. However, no studies to date have comprehensively analysed the lipid composition and bioactivity of Ziziphi spinosae semen oil processed using different methods.

Isolation and microbial transformation of tea sapogenin from seed pomace of Camellia oleifera with anti-inflammatory effects.

In the current study, tea saponin, identified as the primary bioactive constituent in seed pomace of Camellia oleifera Abel., was meticulously extracted and hydrolyzed to yield five known sapogenins: 16-O-tiglogycamelliagnin B (a), camelliagnin A (b), 16-O-angeloybarringtogenol C (c), theasapogenol E (d), theasapogenol F (e). Subsequent biotransformation of compound a facilitated the isolation of six novel metabolites (a1-a6).

Direct Synthesis of α- and β-2'-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation.

2'-Deoxynucleosides and analogues play a vital role in drug development, but their preparation remains a significant challenge. Previous studies have focused on β-2'-deoxynucleosides with the natural β-configuration. In fact, their isomeric α-2'-deoxynucleosides also exhibit diverse bioactivities and even better metabolic stability.

Utilizing rubidium chloride as an effective and stable interface modification layer for high-efficiency solar cells.

The presence of interface defects between the perovskite layer and the underlying substrate has a significant impact on the power conversion efficiency (PCE) and stability of perovskite solar cells (PSCs). thin films are employed in PSCs as electron transport layers to achieve high PCE. However, the significant lattice mismatch between and the perovskite material leads to a large number of uncoordinated defects at the interface between perovskite and substrate, resulting in recombination losses at the interface.

promotes parenchyma cell and vascular bundle development in sugar beet ( L.) taproot.

Constitutive photomorpogenic dwarf () is a pivotal enzyme gene for brassinolide (BR) synthesis and plays an important role in plant growth, including increasing plant biomass and plant height, elongating cells, and promoting xylem differentiation. However, little is known about the function of the gene in sugar beet. In the current study, we isolated from L.

Novel MeON-glycosides of ursolic acid: Synthesis, antitumor evaluation, and mechanism studies.

Ursolic acid (UA) is a pentacyclic triterpenoid widely found in in medicinal plants, edible plants, fruits, and flowers. The great interest in this bioactive compound is related to the positive effects in human health. However, its limited solubility, moderate biological activity and poor bioavailability limit the potential and further applications of UA.

Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1.

Checkpoint inhibitors such as PD-1/PD-L1 antibody therapeutics are a promising option for the treatment of multiple cancers. Due to the inherent limitations of antibodies, great efforts have been devoted to developing small-molecule PD-1/PD-L1 signaling pathway inhibitors. In this study we established a high-throughput AlphaLISA assay to discover small molecules with new skeletons that could block PD-1/PD-L1 interaction.

Integration of Transcriptomic and Proteomic Profiles Reveals Multiple Levels of Genetic Regulation of Taproot Growth in Sugar Beet ( L.).

Sugar beet taproot growth and development is a complex biological process involving morphogenesis and dry matter accumulation. However, the molecular regulatory mechanisms underlying taproot growth and development remain elusive. We performed a correlation analysis of the proteome and transcriptome in two cultivars (SD13829 and BS02) at the start and the highest points of the taproot growth rate.

Real-time wear monitoring of hob cutter based on statistical analysis.

Real-time wear monitoring of hob cutters is of great significance to the quality and efficiency of gear hobbing. To achieve this goal, a strategy based on statistical analysis is proposed in this paper. First, vibration signals during the entire life cycle of a hob cutter are collected.

Microscale gratings patterned in perovskite films to promote the electron-optical conversion efficiency of perovskite light-emitting diodes.

In this paper, we investigated an enhancement of luminance in a perovskite light-emitting diode (PeLED) by inserting periodic microscale gratings. Soft imprinting was employed to pattern the gratings onto the surface of perovskite film in the annealing process. It was found that the grain-refining effect deeply influenced the morphology and crystallinity of the perovskite film.

Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation.

The transcription factor FOXM1 that regulates multiple proliferation-related genes through selective protein-DNA and protein-protein interactions is now considered an attractive oncotarget. There are several small-molecule inhibitors that indirectly suppress the expression of FOXM1 or block its DNA binding domain (FOXM1-DBD). However, insufficient specificity or/and efficacy are two potential drawbacks.

Brassinosteroids promote parenchyma cell and secondary xylem development in sugar beet ( L.) root.

Increasing crop yield has always been an important goal in agriculture. Brassinosteroids (BRs) are growth-promoting steroid hormones with vital roles in many root developmental processes. Sugar beet ( L.

Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies.

In this research, a series of novel diosgenin-1,4-quinone hybrids were synthesized and evaluated in antiproliferative assays against three human cancer cell lines (MCF-7, HepG2, and HeLa). Structure-activity relationship analysis revealed that the activities depended on the type of 1,4-quinone moiety. Among them, hybrid 11a exhibited significant cytotoxicity against the HepG2 cell line with a IC of 1.

Quantum routings for single photons with different frequencies.

Controllable single-photon routing takes the central roles in optical quantum networks for quantum information processing. Given that most of the schemes previously proposed are specifically designed for the photons with selected frequencies, here we investigate how to implement the routings of single photons with different frequencies. We show that the routing capabilities of the photons with different frequencies are manipulatable by properly designing the configuration of the scatters such as the cavity with embedded atoms and the channel boundaries.

Synthesis of MeON-Glycoside Derivatives of Oleanolic Acid by Neoglycosylation and Evaluation of Their Cytotoxicity Against Selected Cancer Cell Lines.

A series of C-3 and C-28 MeON-neoglycosides of oleanolic acid were designed and synthesized by neoglycosylation as potential antiproliferative agents. Their cytotoxicity was evaluated in vitro against five human cancer cell lines: human non-small cell lung cancer cell line (A549), human melanoma cell line (A375), human colon cancer cell line (HCT116), human liver carcinoma cell line (HepG2), human breast adenocarcinoma cell line (MCF-7) by the Cell Counting Kit-8 (CCK-8) assay. Most of C-3 and C-28 MeON-neoglycosides of oleanolic acid exhibited notably inhibitory effects against the tested cancer cells and more sensitive to HepG2 cells than 5-Fluorouracil (5-FU).

Design, Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents.

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds' cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure-activity relationships (SAR) are discussed.