Publications by authors named "Guokai Wu"
Article Synopsis
- Arsenic exposure harms the neurological system by inhibiting the growth of new neurons in the hippocampus, but this damage can be reversed once exposure stops.
- The study tested whether combining taurine with arsenic could improve neurogenesis and reduce depression-like behaviors in mice, with groups receiving various treatments over four months.
- Results showed that taurine co-administration significantly improved neuron levels and reduced depressive symptoms compared to arsenic alone, suggesting mechanisms include reduced oxidative stress and inflammation, along with increased neurotrophic factors.
Inhibition of ferroptosis in intestinal epithelial cells serves as an attractive target for the development of therapeutic strategies for colitis. Pinobanksin, one of the main flavonoids derived from propolis, possesses significant anti-inflammatory effects and inhibits the cell death of several cell lines. Here, we evaluated whether pinobanksin influenced colitis by modulation of epithelial ferroptosis.
View Article and Find Full Text PDFActivation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases.
View Article and Find Full Text PDFGenetic load expresses the loss in mean fitness of a population because of the genetic variability present. The quantitative discussion of various genetic loads is provided with important meaning for research into evolution of species on realistic level. The past theory on genetic load starts off with equilibrium of population to investigate the evolution of species on realistic level.
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