Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer.

Objective: The effects of arsenic trioxide (AsO) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in AsO-induced apoptosis in liver cancer cells.

A Hypoxia-Related miRNA-mRNA Signature for Predicting the Response and Prognosis of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma.

Purpose: Transcatheter arterial chemoembolization (TACE) is commonly used in the treatment of hepatocellular carcinoma (HCC). However, not all patients respond to this treatment. TACE typically leads to hypoxia in the tumor microenvironment.

The therapeutic principle of combined clearing heat and resolving toxin plus TACE on primary liver cancer: A systematic review and meta-analysis.

Ethnopharmacological Relevance: Transcatheter arterial chemoembolization (TACE) is recommended as the first-line therapy for unresected primary liver cancer (PLC), but only partial patients could benefit from TACE due to the serious adverse reactions. Clearing heat and resolving toxin (CHRT), one of most critical traditional Chinese medicine (TCM) therapeutic principles, has been widely used in the treatment of PLC patients especially after TACE. However, there is no enough clinical evidence to confirm the efficacy and safety of the combined therapy.

Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control.

Background: Baphicacanthis Cusiae Rhizoma et Radix, commonly known as Nan-Ban-Lan-Gen (NBLG), is an essential traditional Chinese medicine that possesses diverse bioactivities, particularly noteworthy for its antiviral properties. Although NBLG has been listed in the Chinese Pharmacopoeia as an independent Chinese medicine, the establishment of a comprehensive quality standard for NBLG remains elusive. The absence of assay for marker compound in its quality standards has led to the lack of corresponding quality control measures for NBLG-containing preparations, and its discrimination from adulterant species in the market which thereby can significantly impact the efficacy and safety of NBLG-containing products.

Effects of Corrosion Products Deposited on 304 Stainless Steel on Reduction of Se (IV/VI) in Simulated Groundwater.

Selenium (Se) is a key mobile fission product in the geological disposal of nuclear waste. It is necessary to analyze the reductive deposition behavior of iron-based materials to Se(IV) and Se(VI) in groundwater. In the present work, the corrosion behavior of 304 stainless steel in simulated groundwater (SG) and the effects of corrosion products on the dissolution of Se were investigated by electrochemical and immersion tests.

UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell-Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling.

A hypoxic microenvironment may induce angiogenesis and promote the development of hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether ursodeoxycholic acid (UDCA) may inhibit hypoxic HCC cell-induced angiogenesis and the possible mechanisms. Tube formation and matrigel plug angiogenesis assays were used to evaluate angiogenesis and respectively.

Effects of Different Ions and Temperature on Corrosion Behavior of Pure Iron in Anoxic Simulated Groundwater.

As a typical material of the insert in high-level radioactive waste (HLW) geological disposal canisters, iron-based materials will directly contact with groundwater after the failure of a metallic canister, acting as a chemical barrier to prevent HLW leaking into groundwater. In this paper, anoxic groundwater was simulated by mixing 10 mM NaCl and 2 mM NaHCO purged by Ar gas (containing 0.3% CO) with different added ions (Ca, CO and SiO) and operation temperatures (25, 40 and 60 °C).