Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells.

Osteosarcoma is the most common type of primary malignant bone tumor and has a high propensity to metastasize to the lungs and bones. Calbindin 1 () is a constituent Ca2+ binding protein, which can prevent apoptotic death in several cell types induced through various pro-apoptotic signaling pathways. To investigate whether is implicated in the tumor growth of human osteosarcoma, two different short hairpin RNAs (shRNAs) against were used for -knockdown in osteosarcoma U2OS cells.