NBS-mediated C(sp)-H amidation of -dimethylamides with -acyloxyamides.

Presented herein is the NBS-mediated amidation of the C(sp)-H bond adjacent to the nitrogen atom of ,-dimethylamide using -acyloxyamide as the amide source, leading to a diverse array of methylenebisamides. The transformation features mild conditions, excellent functional group tolerance, and high efficiency. The practicality of the methodology was shown by gram-scale synthesis and efficient product derivatization.