Continuous prediction for tumor mutation burden based on transcriptional data in gastrointestinal cancers.

Background: Tumor mutation burden (TMB) has been considered a biomarker for utilization of immune checkpoint inhibitors(ICIs), but whole exome sequencing(WES) and cancer gene panel(CGP) based on next generation sequencing for TMB detection are costly. Here, we use transcriptome data of TCGA to construct a model for TMB prediction in gastrointestinal tumors.

Methods: Transcriptome data, somatic mutation data and clinical data of four gastrointestinal tumors from TCGA, including esophageal cancer (ESCA), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ).

Identification of specific role of SNX family in gastric cancer prognosis evaluation.

We here perform a systematic bioinformatic analysis to uncover the role of sorting nexin (SNX) family in clinical outcome of gastric cancer (GC). Comprehensive bioinformatic analysis were realized with online tools such as TCGA, GEO, String, Timer, cBioportal and Kaplan-Meier Plotter. Statistical analysis was conducted with R language or Perl, and artificial neural network (ANN) model was established using Python.

Synthesis of 1,6-Dihydropyridine-3-carbonitrile Derivatives Lewis Acid-Catalyzed Annulation of Propargylic Alcohols with ()-3-Amino-3-phenylacrylonitriles.

A novel Lewis acid-catalyzed, highly efficient, practical, and atom-economical protocol for the synthesis of functionalized 1,2-dihydropyridine-3-carbonitrile derivatives in the presence of Bi(OTf) (10 mol %) in tetrahydrofuran (2.0 mL) at 80 °C for 8 h in air is described, starting from readily accessed propargylic alcohols and ()-3-amino-3-phenylacrylonitriles. This cycloaddition protocol, which is scalable and proceeds under mild conditions, is amenable to the gram-scale construction of valuable 1,2-dihydropyridine-3-carbonitriles.

Effective Dose Coefficients for Intakes of Uranium Via Contaminated Wounds for Reference Adults.

Effective dose coefficients for intakes of uranium radionuclides via contaminated wounds have been calculated for reference adults following the procedures in the ICRP 103 series. The number of transformations in each source region for all members of the radioactive series from time of intake to 50 y post intake are calculated by coupling the NCRP 156 wound model to the ICRP 137 systemic models and ICRP 100 human alimentary tract model. Together with the ICRP 107 nuclear decay data for dosimetric calculations, the ICRP 133 specific absorbed fractions are implemented to calculate the radiation-weighted S coefficient deposited in each target organ or tissue from each transformation in each source region.

Biokinetic Method on Simultaneous Intake of Radionuclides from Multiple Intake Scenarios for Application in Internal Exposures.

Biokinetics underlies the basis for assessment of internal exposures. This paper develops a biokinetic method on simultaneous intake of radionuclides from multiple intake scenarios in internal exposures. With numerical techniques that transform the whole biokinetics between the coupled and decoupled representations of the same problem, this method applies to coupled biokinetics with complex structures and has no restrictions of practical importance on the number of intake scenarios, the number of intake parent radionuclides and decay products, and the complexity of decay relationships between parent and progeny nuclides.

Dicyanovinyl substituted push-pull chromophores: effects of central C[double bond, length as m-dash]C/phenyl spacers, crystal structures and application in hydrazine sensing.

To discern the distinctive effect of the C[double bond, length as m-dash]C bond and the phenyl bridge on the photophysical and chemical properties of D-π-A molecular systems, three new dicyanovinyl substituted push-pull chromophores 1-3 containing either a C[double bond, length as m-dash]C bond or a phenyl ring as the central π-linker were synthesized by the Suzuki-Miyaura and Knoevenagel reactions. Together with the counterpart of 1 developed by Zhang's group (TPE-z), their optical properties and single crystal structures were systematically and comparatively investigated. Notably, the simple π-extension of a C[double bond, length as m-dash]C linker to a phenyl ring between electron donor and electron acceptor moieties could greatly affect the photophysical properties of chromophores, particularly leading to significant hypsochromic shifts in both absorption and emission spectra.

Michael-Michael Addition Reactions Promoted by Secondary Amine-Thiourea: Stereocontrolled Construction of Barbiturate-Fused Tetrahydropyrano Scaffolds and Pyranocoumarins.

Bifunctional secondary amine-thiourea organocatalysts were successfully applied in the stereocontrolled synthesis of barbiturate-fused tetrahydropyrano scaffolds. Compared with typically used tertiary amine-thiourea organocatalysts, the developed catalysts exhibited excellent catalytic performance in the domino Michael-Michael reaction between N, N'-dimethylbarbituric acid and Morita-Baylis-Hillman acetates of nitroalkenes to yield pharmaceutically important heterocycles in good yields with excellent enantioselectivities. Moreover, this catalytic protocol can also be applied to synthesize biologically active pyranocoumarin compounds.

A sensitive colorimetric and ratiometric chemosensor for trivalent metal cations.

A novel hydroxyethyl piperazine functionalized cyanine derivative was designed and synthesized. It presents selective colorimetric as well as ratiometric absorption responses to trivalent metal cations (Cr(3+), Fe(3+) and Al(3+)) over a variety of divalent and monovalent metal cations in 3:7 ethanol-water solution. Detection limits of this method for Cr(3+), Fe(3+) and Al(3+) were 3.

Regulating the piezofluorochromism of 9,10-bis(butoxystyryl)anthracenes by isomerization of butyl groups.

Isomers of 9,10-bis(butoxystyryl)anthracene (DSA4), including n-butyl, i-butyl and t-butyl at ortho or para positions, were designed and synthesized. All of them display an aggregation-induced emission phenomenon. Remarkably, it was found that isomerization of butyl endgroups presents significant influences on their piezofluorochromic properties.