Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial.

Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the quality of life of patients with allergic rhinitis.

Objectives: In this study, we evaluated whether the effect of AzeFlu, a generic drug manufactured from China, is equivalent to that of MP-AzeFlu.

Encapsulation of Fatty Acids Using Linear Dextrin from Waxy Potato Starch: Effect of Debranching Time and Degree of Unsaturation.

This study investigates the effects of the debranching time of waxy potato starch using pullulanase and recrystallization on particle morphology, debranching degree, and crystal structure. The results demonstrated that after gelatinization and debranching, the surface of the starch crystals became rough and uneven due to hydrolysis, with most particles showing a fragmented surface. The crystalline state was not significantly changed with debranching time.

Augmented antibacterial performance of MoS-integrated lignin-polyaniline composites through near-infrared stimulated photothermal and peroxidase-like activities.

Photothermal synergistic antibacterial therapy has emerged as a compelling approach for addressing antibiotic-resistant infections. In this study, lignosulfonate (LS) served dual roles as both a scaffolding template and a functional modifier in the fabrication of the lignin-polyaniline composite (LS-PANI). Subsequently, molybdenum disulfide (MoS) was integrated into LS-PANI through physical adsorption, resulting in the formation of MoS@LS-PANI.

LINC00870 promotes imatinib resistance in gastrointestinal stromal tumor via inhibiting PIGR glycosylation modifications.

Imatinib is the first-line targeted therapy for gastrointestinal stromal tumor (GIST), but resistance frequently occurs during treatment, limiting its efficacy and clinical application. We performed high-throughput sequencing of tissue specimens from imatinib-resistant GIST patients, and identified significantly high expression of polymeric immunoglobulin receptor (PIGR) in imatinib-resistant cell lines. Further investigation revealed that PIGR binds specifically to LINC00870.

[Clinical treatment strategy for pT3N0 laryngeal squamous cell carcinoma].

To investigate optimal treatment strategy for pT3N0 laryngeal squamous cell carcinoma（SCC）. A retrospective study of 150 patients with pT3N0 laryngeal SCC treated in the First Affiliated Hospital of Chongqing Medical University was performed. The efficacies of partial laryngectomy and total laryngectomy, as well as surgery alone and postoperative radiotherapy were evaluated.

Tumor Microenvironment-Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression.

The clinical efficacy of immune checkpoint blockade (ICB) therapy is significantly compromised in the metabolically disordered tumor microenvironment (TME), posing a formidable challenge that cannot be ignored in current antitumor strategies. In this study, TME-responsive nanoparticles (HMP1G NPs) loaded with 1-methyltryptophan (1-MT; an indoleamine 2,3-dioxygenase 1 [IDO1] inhibitor,) and S-nitrosoglutathione (GSNO; a nitric oxide donor) is developed to enhance the therapeutic efficacy of 1-MT-mediated ICB. The HMP1G NPs responded to H and glutathione in the TME, releasing Mn, GSNO, and 1-MT.

High-performance and scalable polarization splitter-rotator based on photonic crystal nanobeam reflection.

The polarization splitter-rotator (PSR) is a key device for polarization processing in polarization diversity systems, which has wide applications in achieving polarization independence and mixed multiplexing. However, it remains a significant challenge to simultaneously achieve a better balance in bandwidth, crosstalk (CT), polarization extinction ratio (PER), and compact footprint of the PSR. In this article, a photonic crystal nanobeam (PCN) structure is introduced to PSR for large bandwidth and compact size, with a device length of only 104 µm.

Flexible and reconfigurable integrated optical filter based on tunable optical coupler cascaded with coupled resonator optical waveguide.

Reconfigurable optical filter can satisfy diverse filtering requirements in different application scenarios and shorten development cycle. However, it is still challenging to achieve multi-functional filtering richness with high performance. Here, based on a tunable optical coupler cascaded with a coupled resonator optical waveguide (CROW), a highly flexible and reconfigurable integrated optical filter is proposed and demonstrated on the low-loss silicon nitride platform.

Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer.

Extramural venous invasion (EMVI) detected by computed tomography has been identified as an independent risk factor for distant metastasis in patients with advanced gastric cancer (GC). Cancer-associated fibroblasts (CAFs) are critical for remodeling the tumor microenvironment in GCs. Here, we report that MFAP5+ CAFs promote the formation of EMVI imaging in GC.

Harnessing Physical Entropy Noise in Structurally Metastable 1T' Molybdenum Ditelluride for True Random Number Generation.

True random numbers are crucial for various research and engineering problems. Their generation depends upon a robust physical entropy noise. Here, we present true random number generation from the conductance noise probed in structurally metastable 1T' molybdenum ditelluride (MoTe).

Scalable Synaptic Transistor Memory from Solution-Processed Carbon Nanotubes for High-Speed Neuromorphic Data Processing.

Neural networks as a core information processing technology in machine learning and artificial intelligence demand substantial computational resources to deal with the extensive multiply-accumulate operations. Neuromorphic computing is an emergent solution to address this problem, allowing the computation performed in memory arrays in parallel with high efficiencies conforming to the neural networks. Here, scalable synaptic transistor memories are developed from solution-sorted carbon nanotubes.

Regulatory Effects of SLC7A2-CPB2 on Lymphangiogenesis: A New Approach to Suppress Lymphatic Metastasis in HNSCC.

Background: Lymph node metastasis (LNM) is a critical factor affecting the outcomes of head and neck squamous cell carcinoma (HNSCC) and the main reason for treatment failure. This study was designed to examine the effects of the key genes involved in the LNM of HNSCC.

Methods: Tissue samples (HNSCC) were examined by transcriptome sequencing, and the core genes associated with LNM were detected via bioinformatics analysis.

Continuously tunable silicon waveguide optical switched delay line based on grating-assisted contradirectional coupler.

The integrated optical delay line plays a crucial role in microwave photonic chips. Continuous tunability is a growing trend in filtering and beamforming techniques of microwave photonics. Based on the silicon platform, we present and experimentally demonstrate an integrated continuously optical tunable delay line (OTDL) chip, which contains a 4-bit optical switched delay line (OSDL) and a thermally tunable delay line based on grating-assisted Contradirectional coupler (CDC).

Low loss, wideband, and high extinction ratio TM polarizer based on subwavelength gratings.

We propose a low loss, wideband silicon transverse magnetic (TM) polarizer with high polarization extinction ratio and low reflection based on subwavelength grating. By arranging and optimizing a mutually perpendicular subwavelength grating with different duty cycles as the core and cladding, efficient waveguiding and radiation can be achieved for the TM and transverse electric (TE) injection, respectively. In simulation, the proposed TM polarizer has a footprint of 40µ×16.

Molecule Crowding Strategy in Polymer Electrolytes Inducing Stable Interfaces for All-Solid-State Lithium Batteries.

All-solid-state lithium batteries with polymer electrolytes suffer from electrolyte decomposition and lithium dendrites because of the unstable electrode/electrolyte interfaces. Herein, a molecule crowding strategy is proposed to modulate the Li coordinated structure, thus in situ constructing the stable interfaces. Since 15-crown-5 possesses superior compatibility with polymer and electrostatic repulsion for anion of lithium salt, the anions are forced to crowd into a Li coordinated structure to weaken the Li coordination with polymer and boost the Li transport.

Memristor-based adaptive neuromorphic perception in unstructured environments.

Efficient operation of control systems in robotics or autonomous driving targeting real-world navigation scenarios requires perception methods that allow them to understand and adapt to unstructured environments with good accuracy, adaptation, and generality, similar to humans. To address this need, we present a memristor-based differential neuromorphic computing, perceptual signal processing, and online adaptation method providing neuromorphic style adaptation to external sensory stimuli. The adaptation ability and generality of this method are confirmed in two application scenarios: object grasping and autonomous driving.

Ultrahigh extinction ratio and a low power silicon thermo-optic switch.

The silicon thermo-optic switch (TOS) is one of the most fundamental and crucial blocks in large-scale silicon photonic integrated circuits (PICs). An energy-efficient silicon TOS with ultrahigh extinction ratio can effectively mitigate cross talk and reduce power consumption in optical systems. In this Letter, we demonstrate a silicon TOS based on cascading Mach-Zehnder interferometers (MZIs) with spiral thermo-optic phase shifters.

[Clinical analysis of diversity of defect repair with supraclavicular island flap after head and neck tumor surgery].

To investigate the diversity and clinical effect of supraclavicular island flap in repairing the defect after head and neck tumor surgery. A retrospective analysis was performed on 30 patients who received the repair of head and neck defects with supraclavicular island flaps at Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Chongqing Medical University from January 2017 to March 2023. The sites and types of defects, intraoperative blood loss, time of flaps preparation, areas of flaps, survival of the flaps and other complications were recorded.

[Prognostic impact of different tumor invasion patterns in the surgical treatment of T3 glottic laryngeal cancer].

To investigate the prognostic impact of different tumor invasion patterns in the surgical treatment of T3 glottic laryngeal cancer. A retrospective analysis was conducted on the clinical data of 91 patients with T3 glottic laryngeal cancer. Among the 91 patients, 58 cases （63.

[Significance of neoadjuvant immunotherapy combined with chemotherapy in the treatment of larynx preservation in locally advanced hypopharyngeal squamous cell carcinoma].

To evaluate the clinical significance of neoadjuvant immunotherapy combined with chemotherapy in the treatment of larynx preservation in locally advanced hypopharyngeal squamous cell carcinoma. Patients with locally advanced HPSCC（cT3-T4aN0-N3M0） were eligible. All received 2 cycles of pembrolizumab combined with docetaxel and platinum neoadjuvant induction therapy.