Publications by authors named "Guohong Ruan"

Drinking water is an essential daily intake to hydrate the body. It is conceivable that water, when endowed with antioxidant properties, will be the most natural radical terminator surpassing conventional pill-based or food-derived antioxidants. However, current end-of-pipe purification of municipal water generally depletes minerals pivotal for antioxidant potency.

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Objective: To explore the effect of strontium in drinking water on blood pressure in hypertensive mice and its possible mechanism.

Methods: Establishment of mouse model of high blood pressure by drinking 2 mg/mL N'nitro-L-arginine methyl eater hydrochloride(L-NAME) for 4 weeks. One hundred ICR mice were randomly divided into normal control group(n=20) and model group(n=80) according to systolic blood pressure.

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Objective: To evaluate the disinfection efficacy and mechanism of neutral electrolyzed water(NEW) on Staphylococcus albus.

Methods: The bactericidal effect of NEW was observed through suspension quantitative bactericidal test. In addition, to analyze the mechanism of NEW, the leakage of bacterial contents and enzyme activity were tested, and the damage of bacterial protein and DNA were determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis and agarose gel electrophoresis.

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Oxidative stress and inflammation play an important role in hypertensive animals and patients. Hydrogen plays a role of antioxidation and anti-inflammation. Calcium and magnesium play an important role in reducing hypertension and antioxidant.

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Objective: To explore the effect of three kinds of drinking water and its possible mechanism on blood pressure of hypertensive mice.

Methods: The water quality parameters were measured for three kinds of drinking water, and the parameters includedtotal dissolved solids( TDS), oxygen consumed( OC), p H, oxidation reduction potential( ORP), electric conductivity( EC), dissolved hydrogen, calcium and magnesium. Establishment of mouse model of high blood pressure by using N'-nitro-L-arginine methyl ester hydrochloride( L-NAME) for 30 days.

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Objective: To explore the effect of three kinds of drinking water on learning and memory and hippocampal neurotransmitter of mice.

Methods: Water quality parameters, including total dissolved solid( TDS), total hardness, oxygen consumed( OC), sodium, potassium, calcium, magnesium and metasilicic acid, were measured for pure water, tap water and natural mineral water. A total of 60 ICR mice( half male and half female) were randomly divided into three groups and fed with pure water( control group), tap water and mineral water for 90 days.

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Objective: To explore the effect of different drinking water on hepatic and renal function and zinc and iron concentrations of different organs in mice.

Methods: Zinc and iron concentrations were measured in pure water, tap water, mineral water and filtered tap-water, respectively. 80 ICR mice (half male and half female) were randomly divided into four groups and fed with pure water (control group), tap water, mineral water and filtered tap-water, respectively.

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Objective: To observe changes of dopamine and its metabolite (3,4-hydroxyphenylaceticacid, DOPAC) levels of the brain regions in rats exposed by dimethoate (DM).

Methods: Groups of rats were treated with saline and 38.9, 83.

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Objective: To study the effect of dimethoate on the monoamine Neurotransmitters, including norepinephrine (NE), epinephrine (E), serotonin (5-HT), dopamine (DA) and its metabolite (3, 4-hydroxyphenylacetic acid, DOPAC) in the serum of rats and furthermore to explore the non-cholinergic mechanism of organophosphate induced toxicity.

Methods: Groups of rats were treated with saline and 38.9, 83.

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Objective: A rapid, reliable and simple method detecting monoamine neurotransmitters in rat serum and brain tissue by high performance liquid chromatography with electrochemical detector was developed.

Methods: An ODS column was selected as separation column at room temperature,and the mobile phase (pH4.50) consisted of 0.

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