Publications by authors named "Guohao Han"

The food safety risks posed by exposure to polystyrene microplastics (PS-MPs) and bisphenol A (BPA) have become an issue worldwide. However, the toxic effects of PS-MPs and BPA coexposure on the mammalian liver remain elusive. In this study, we found that PS-MPs and BPA coexposure have synergistic toxic effects on AML12 cells and the mouse liver.

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In addition to being a major source of animal protein, pigs are an important model for the study of development and diseases in humans. During the past two decades, thousands of high-throughput sequencing studies in pigs have been performed using a variety of tissues from different breeds and developmental stages. However, the multi-omics database specifically used for pig functional genomic research is still limited.

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The circadian clock regulates various physiological processes in mammals. The core circadian clock gene Bmal1 is crucial for maintaining the oscillations of the circadian clock system by controlling the rhythmic expression of numerous circadian clock-controlled genes. To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis.

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Article Synopsis
  • Powdery mildew, caused by Blumeria graminis f. sp. tritici, is a highly destructive disease impacting wheat, particularly affecting common wheat, but durum wheat serves as a key resource for enhancement efforts.* -
  • The study identified a durum wheat variety (DR88) with strong resistance to powdery mildew, localizing the dominant resistance gene, PmDR88, to a specific region on chromosome arm 2AL and confirming its association with the Pm4 locus through extensive genotyping.* -
  • Despite PmDR88 sharing amino acid sequences with the Pm4d allele, it has distinct expression patterns; two complementary DNA markers were developed for efficient marker-assisted selection to integrate this
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Identification and functional analysis of key genes regulated by the circadian clock system will provide a comprehensive understanding of the underlying mechanisms through which circadian clock disruption impairs the health of living organisms. The initial phase involved bioinformatics analysis, drawing insights from three RNA-seq datasets (GSE184303, GSE114400, and GSE199061) derived from wild-type mouse liver tissues, which encompassed six distinct time points across a day. As expected, 536 overlapping genes exhibiting rhythmic expression patterns were identified.

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Rye (Secale cereale), a valuable relative of wheat, contains abundant powdery mildew resistance (Pm) genes. Using physical mapping, transcriptome sequencing, barley stripe mosaic virus-induced gene silencing, ethyl methane sulfonate mutagenesis, and stable transformation, we isolated and validated two coiled-coil, nucleotide-binding site and leucine-rich repeat (CC-NBS-LRR) alleles, PmTR1 and PmTR3, located on rye chromosome 6RS from different triticale lines. PmTR1 confers age-related resistance starting from the three-leaf stage, whereas its allele, PmTR3, confers typical all-stage resistance, which may be associated with their differential gene expression patterns.

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There are significant differences in meat production, growth rate and other traits between Western commercial pigs and Chinese local pigs. Comparative transcriptome approaches have identified many coding and non-coding candidate genes associated various traits. However, the expression and function of circular RNAs (circRNAs) in different pig tissues are largely unknown.

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Novel wheat-rye 6RS small fragment translocation lines with powdery mildew resistance were developed, and the resistance gene PmW6RS was physically mapped onto 6RS-0.58-0.66-bin corresponding to 18.

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Article Synopsis
  • Powdery mildew is a global disease affecting wheat, and host resistance is the best way to control it, protecting both the environment and the economy.
  • In this study, researchers tested 600 wheat cultivars for resistance, identifying 116 resistant genotypes, which were then crossbred to analyze their genetic inheritance patterns.
  • The findings revealed several genotypes with known and unknown resistant genes, highlighting the prevalence of certain alleles in wheat production and suggesting opportunities to enhance genetic diversity for resistance against powdery mildew.
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Background: Plant height (PH), spike length (SL) and spike compactness (SCN) are important agronomic traits in wheat due to their strong correlations with lodging and yield. Thus, dissection of their genetic basis is essential for the improvement of plant architecture and yield potential in wheat breeding. The objective of this study was to map quantitative trait loci (QTL) for PH, SL and SCN in a recombinant inbred line (RIL) population derived from the cross 'PuBing3228 × Gao8901' (PG-RIL) and to evaluate the potential values of these QTL to improve yield.

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Powdery mildew, caused by f. sp. (), is a destructive fungal disease of wheat throughout the world.

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Developing effective and durable host plant resistance is crucial for controlling powdery mildew, a devastating disease caused by f. sp. ().

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Powdery mildew of wheat (), caused by f.sp. (), is a destructive disease that seriously threatens the yield and quality of its host.

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Inspired by the mussel foot proteins, polydopamine nanoparticles (PDA NPs) are often used to design hydrogel wound dressings due to their strong wet adhesion. However, additional antibiotics or nanometal bactericides are always required to enhance their poor antibacterial activity, which will cause drug resistance and toxic side effects. Herein, self-assembly confined PDA NPs (SC-PDA NPs, <50 nm) are employed as a freestanding antibacterial ingredient for constructing an ideal hydrogel wound dressing, which maintains relatively strong reducibility and size effect.

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Rye ( L.), a naturally cross-pollinating relative of wheat, is a tertiary gene donor and of substantial value in wheat improvement. Wheat powdery mildew is caused by f.

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Powdery mildew, caused by f. sp. , is a devastating disease of wheat that seriously affects yield and quality worldwide.

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Article Synopsis
  • Powdery mildew and leaf rust are common diseases affecting wheat globally, and using resistant wheat cultivars is the best way to control these issues economically and environmentally.
  • In a study of 2,978 wheat accessions, 22.1% showed high resistance to powdery mildew and some accessions were also resistant to leaf rust, with 17 accessions resistant to both diseases.
  • Genetic testing revealed specific resistance genes in many accessions, identifying a total of 10 genes associated with leaf rust and 7 with powdery mildew, while also suggesting the presence of unknown resistance genes not previously characterized.
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Wheat-rye T1RS·1BL translocations have been widely used worldwide in wheat production for multiple disease resistance and superior yield traits. However, many T1RS·1BL translocations have successively lost their resistance to pathogens due to the coevolution of pathogen virulence with host resistance. Because of the extensive variation in rye ( L.

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