Evaluation of the Efficacy of the Vaccine Production Process in Removing Residual Host Cell DNA from the Vero Cell Rabies Vaccine.

Background: The Vero cell rabies vaccine is currently the most widely used human rabies vaccine. However, owing to the presence of residual host cell DNA (HCD) in the final product and the potential tumorigenicity of the DNA of high-passage Vero cells, the WHO not only sets a limit on the number of times cells used in production can be passaged, but also imposes strict requirements on the amount of residual HCD in the final vaccine product.

Objectives: To systematically reduce the HCD level in the final vaccine product, multiple purification steps are included in the vaccine production process.

G-RCenterNet: Reinforced CenterNet for Robotic Arm Grasp Detection.

In industrial applications, robotic arm grasp detection tasks frequently suffer from inadequate accuracy and success rates, which result in reduced operational efficiency. Although existing methods have achieved some success, limitations remain in terms of detection accuracy, real-time performance, and generalization ability. To address these challenges, this paper proposes an enhanced grasp detection model, G-RCenterNet, based on the CenterNet framework.

CabbageNet: Deep Learning for High-Precision Cabbage Segmentation in Complex Settings for Autonomous Harvesting Robotics.

Reducing damage and missed harvest rates is essential for improving efficiency in unmanned cabbage harvesting. Accurate real-time segmentation of cabbage heads can significantly alleviate these issues and enhance overall harvesting performance. However, the complexity of the growing environment and the morphological variability of field-grown cabbage present major challenges to achieving precise segmentation.

Joint Fault Diagnosis of IGBT and Current Sensor in LLC Resonant Converter Module Based on Reduced Order Interval Sliding Mode Observer.

LLC resonant converters have emerged as essential components in DC charging station modules, thanks to their outstanding performance attributes such as high power density, efficiency, and compact size. The stability of these converters is crucial for vehicle endurance and passenger experience, making reliability a top priority. However, malfunctions in the switching transistor or current sensor can hinder the converter's ability to maintain a resonant state and stable output voltage, leading to a notable reduction in system efficiency and output capability.

Enhanced FFT-Root-MUSIC Algorithm Based on Signal Reconstruction via CEEMD-SVD for Joint Range and Velocity Estimation for FMCW Radar.

Frequency-modulated continuous-wave (FMCW) radar is used to extract range and velocity information from the beat signal. However, the traditional joint range-velocity estimation algorithms often experience significant performances degradation under low signal-to-noise ratio (SNR) conditions. To address this issue, this paper proposes a novel approach utilizing the complementary ensemble empirical mode decomposition (CEEMD) combined with singular value decomposition (SVD) to reconstruct the beat signal prior to applying the FFT-Root-MUSIC algorithm for joint range and velocity estimation.

Multipopulation Whale Optimization-Based Feature Selection Algorithm and Its Application in Human Fall Detection Using Inertial Measurement Unit Sensors.

Feature selection (FS) is a key process in many pattern-recognition tasks, which reduces dimensionality by eliminating redundant or irrelevant features. However, for complex high-dimensional issues, traditional FS methods cannot find the ideal feature combination. To overcome this disadvantage, this paper presents a multispiral whale optimization algorithm (MSWOA) for feature selection.

Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment.

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due to their excellent biocompatibility, high drug-loading capacity, and tunable drug-release properties. This review systematically examines the matrix materials and fabrication methods of HMN systems, highlighting advancements in natural and synthetic polymers, and explores their applications in treating conditions such as wound healing, hair loss, cardiovascular diseases, and cancer.

Study on the Characterization of Physical, Mechanical, and Creep Properties of Masson Pine and Chinese Fir Wood Flour-Reinforced High-Density Polyethylene Composites.

Improving the physical, mechanical, and creep properties of wood fiber-reinforced polymer composites is crucial for broadening their application prospect. In this research, seven types of high-density polyethylene (HDPE) composites reinforced with different mass ratios of Masson pine ( Lamb.) and Chinese fir [ (Lamb.

Analysis of Interfacial Adhesion Properties Between PBT Azide Propellant Matrix and Defective AP Fillers Using Molecular Dynamics Simulations.

Filler defects and matrix crosslinking degree are the main factors affecting the interfacial adhesion properties of propellants. Improving adhesion can significantly enhance debonding resistance. In this study, all-atom molecular dynamics (MD) simulations are employed to investigate the interfacial adsorption behavior and mechanisms between ammonium perchlorate (AP) fillers and a poly(3,3-bis-azidomethyl oxetane)-tetrahydrofuran (PBT) matrix.

Investigating the Impact of Polymers on Clay Flocculation and Residual Oil Behaviour Using a 2.5D Model.

In the process of oilfield development, the surfactant-polymer (SP) composite system has shown significant effects in enhancing oil recovery (EOR) due to its excellent interfacial activity and viscoelastic properties. However, with the continuous increase in the volume of composite flooding injection, a decline in injection-production capacity (I/P capacity) has been observed. Through the observation of frozen core slices, it was found that during the secondary composite flooding (SCF) process, a large amount of residual oil in the form of intergranular adsorption remained in the core pores.

Effect of Acrylate Emulsion on the Mechanical and Microscopic Properties of Straw Fiber-Reinforced Cement-Magnesium Slag Stabilized Soil.

In order to investigate the mechanism of mechanical performance enhancement and the curing mechanisms of acrylate emulsion (AE) in cement and magnesium slag (MS) composite-stabilized soil (AE-C-M), this study has conducted a comprehensive analysis of the compressive strength and microstructural characteristics of AE-C-M stabilized soil. The results show that the addition of AE significantly improves the compressive strength of the stabilized soil. When the AE content is 0.

Aggressiveness of f. sp. Isolates at High Temperatures: A Study Case in Core Oversummering Area of Gansu as Inoculum Source.

Wheat stripe rust, caused by a biotrophic, obligate fungus f. sp. (), is a destructive wheat fungal disease that exists worldwide and caused huge yield reductions during pandemic years.

Studying the Antifungal Effects of (Sprengel) R. King and H. Robinson (= Sprengel) as a Bio-Fumigant Plant Alone and in Combination with Biochar Against (Edson) Fitz.

spp. are soil-borne pathogens that cause damping-off and root rot diseases in many plant species such as cucumber. In the current study, the effect of dried roots-stems and leaves of (Sprengel) R.

Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes.

Triptolide (TP) is a diterpenoid compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii. It has antitumor and anti-inflammatory effects and stimulates immunity. However, its serious side effects, especially reproductive toxicity, limit its clinical application.

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury.

Background And Aims: Cell-cycle-related and expression elevated protein in tumor (CREPT, also named RPRD1B) is highly expressed in tumors and functions to promote tumorigenesis. However, the role of CREPT in the pathophysiology of acute liver injury is limited. Here, we demonstrate that CREPT plays an essential role during acute liver injury.

The Characteristics, Sources, and Health Risks of Volatile Organic Compounds in an Industrial Area of Nanjing.

This study investigates the chemical complexity and toxicity of volatile organic compounds (VOCs) emitted from national petrochemical industrial parks and their effects on air quality in an industrial area of Nanjing, China. Field measurements were conducted from 1 December 2022, to 17 April 2023, focusing on VOC concentrations and speciations, diurnal variations, ozone formation potential (OFP), source identification, and associated health risks. The results revealed an average total VOC (TVOC) concentration of 15.

The Efficacy and Safety of Roxadustat for Anemia in Hemodialysis Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.

Background: Patients undergoing hemodialysis (HD) for chronic kidney disease (CKD) often encounter anemia. Roxadustat has not only undergone phase II-III clinical trials in patients suffering from CKD and undergoing HD; a number of post-marketing clinical studies have been conducted using the drug. This article was to assess the effectiveness and safety of roxadustat in managing anemia among patients with CKD undergoing HD.

Bacterial Community Structure and Environmental Driving Factors in the Surface Sediments of Six Mangrove Sites from Guangxi, China.

Mangroves, as blue carbon reservoirs, provide a unique habitat for supporting a variety of microorganisms. Among these, bacteria play crucial roles in the biogeochemical processes of mangrove sediments. However, little is known about their community composition, spatial distribution patterns, and environmental driving factors, particularly across the large geographical scales of mangrove wetlands.

Impact of Biochar Addition on Biofloc Nitrifying Bacteria and Inorganic Nitrogen Dynamics in an Intensive Aquaculture System of Shrimp.

In this study, an eight-week culture trial of juveniles was conducted in commercial intensive systems to compare the impacts of biochar and molasses addition on biofloc nitrifying bacteria and inorganic nitrogen dynamics under limited water exchange conditions. During the trial, the biofloc concentration (in terms of VSS and TSS), quantities of total bacteria (TB) and total (TV), and ratio of TV/TB in the culture water were lower in the biochar group compared to the molasses group. Metagenomic sequencing analysis revealed that the bacterial community composition of bioflocs showed higher α-diversity and complexity in the biochar group compared to the molasses group.

Study on the Influence of Au Content and Bonding Parameters on the Free Air Ball Morphology and Bonding Reliability of Ag-Au-Pd Alloy Wire.

This article conducts wire bonding tests and cold/hot-cycle tests using φ 0.025 mm Ag-Au alloy wires and Ag-Au-Pd alloy wires with different specifications. The results show that, due to the addition of the alloying element Pd, under the same bonding parameters, the fracture strength and ball-bonded point shear force of the Ag-Au-Pd alloy wires are significantly higher than those of the Ag-Au alloy wires.

High-Efficiency Precision Polishing Using Fiber Brush-Shear-Thickening Fluid Composites.

Shear-thickening fluid (STF) is widely applied in various practical engineering fields due to its rheological properties of increased viscosity under load. We investigated the integration of STF with fiber brushes to prepare a novel composite material for polishing applications. The impact of composite material properties is studied in surface finish, specifically roughness and morphology, across flat and uneven surfaces.

Design and Implementation of a CMOS-MEMS Out-of-Plane Detection Gyroscope.

A MEMS gyroscope is a critical sensor in attitude control platforms and inertial navigation systems, which has the advantages of small size, light weight, low energy consumption, high reliability and strong anti-interference capability. This paper presents the design, simulation and fabrication of a Y-axis gyroscope with out-of-plane detection developed using CMOS-MEMS technology. The structural dimensions of the gyroscope were optimized through a multi-objective genetic algorithm, and modal, harmonic response and range simulation analyses were carried out to verify the reasonableness of the design.

Design of Two Compact Wideband Monopoles Through Loading with Linear Approximated Lumped Components.

In this paper, two ultra-wideband monopoles in a colinear structure are presented for application in remote terrestrial communication systems. The antennas consist of a loaded monopole with a hat and an elevated loaded monopole located in the upper position. All lumped loads are modeled as linear frequency-dependent components to approximate the practical component property for achieving ultra-wideband characteristics, since the constant value property of a component is only present in a relatively narrow band.

A Novel MZI Fiber Sensor with Enhanced Curvature and Strain Sensitivity Based on Four-Core Fiber.

We present a high-sensitivity curvature and strain Mach-Zehnder interferometer (MZI) fiber sensor based on a configuration of no-core fiber (NCF) and four-core fiber (FCF). We used an optical fiber fusion splicer to directly splice a segment of FCF between two segments of NCF, with both the FCF and NCF made of SiO, where the FCF exhibits multi-path interference characteristics that allow for higher sensitivity. The NCF, with its self-focusing property, excites higher-order modes, which split and transmit it into the four cores of the FCF.

Range Expansion Technology for Ring MEMS Gyroscopes Based on Drive Voltage Modulation.

This paper proposes a method to control the sensitivity of a ring MEMS gyroscope by adjusting the driving control voltage via MEMS. The aim is to explore the relationship between the range of the ring MEMS gyroscope and the driving control voltage, establishing a mathematical model that correlates driving control voltage with sensitivity. By applying different driving voltages to the same gyroscope, the study evaluates the performance and range of the gyroscope.