Publications by authors named "Guoguo Wu"

As a precision mechanical component to reduce friction between components, the rolling bearing is widely used in many fields because of its slight friction loss, strong bearing capacity, high precision, low power consumption, and high mechanical efficiency. This paper reviews several excellent kinds of study and their relevance to the fault detection of rolling bearings. We summarize the fault location, sensor types, bearing fault types, and fault signal analysis of rolling bearings.

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As a medium and low pressure gear machine without automatic compensation structure for axial and radial clearances, the friction pairs in the straight conjugate internal gear pumps (SCIGPs) depend on the fixed small clearances to seal, lubricate and transfer the force. The oil film design of the friction pairs has become an important part of gear pump design. However, there has never been a publicly published research on the oil film design of the SCIGP in past literature.

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The biosynthesis of the valuable antibiotic enduracidin by Streptomyces fungicidicus TXX3120 is a complex multistep process. To identify the rate-limiting step of the entire biosynthetic process, we carried out a deep RNA sequencing towards the mycelia of TXX3120 at different fermentation stages. Comparative RNA-seq analysis indicated that the expression level of the endC gene during the enduracidin production phase was evidently lower than that of the other relevant genes to enduracidin biosynthesis.

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To improve the proteolytic stability of the lipase LIP2 from Yarrowia lipolytica, the peptide bonds susceptible to trypsin in LIP2 were analyzed by tandem mass spectrometry and redesigned by site-directed mutagenesis. Different variants of the enzyme were expressed in Pichia pastoris GS115 and their biochemical properties were subsequently investigated. Although most of the variants were still cleaved by trypsin, some of them did show an evident increase of resistance against proteolytic degradation.

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Synchronous control is a fundamental and significant problem for controlling a multi-joint robot. In this article, by applying two coupled Rayleigh oscillators as the referred central pattern generator models for the two joints of a two-degrees-of-freedom robot, the central pattern generator-based coupling control method is proposed for controlling the two-degrees-of-freedom robot's joints. On these bases, the co-simulation model of the two-degrees-of-freedom robot with the proposed central pattern generator-based coupling control method is established via ADAMS and MATLAB/Simulink, and the performance of the central pattern generator-based coupling control method on synchronizing two motions of two-degrees-of-freedom robot's joints is numerically simulated.

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Our previous report based on a 10 (gravity) silicon-based inertial micro-switch showed that the contact effect between the two electrodes can be improved by squeeze-film damping. As an extended study toward its potential applications, the switch with a large proof mass suspended by four flexible serpentine springs was redesigned to achieve 5 threshold value and enhanced threshold accuracy. The impact of the squeeze-film damping on the threshold value was theoretically studied.

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Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus, which displays high in vitro activity against Gram-positive bacteria including multidrug resistant strains of Staphylococcus aureus. Compared to currently available antibiotics, ficellomycin exhibits a unique mechanism of action-it impairs the semiconservative DNA replication by inducing the formation of deficient 34S DNA fragments, which lack the ability to integrate into larger DNA pieces and eventually the complete bacterial chromosome. Until recently, some important progress has been made in research on ficellomycin synthesis and biosynthesis, opening the perspective to develop a new generation of antibiotics with better clinical performance than the currently used ones.

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Silver nanowires without particles are synthesized by a solvothermal method at temperature 150 °C. Silver nanowires are prepared via a reducing agent of glycerol and a capping agent of polyvinylpyrrolidone (M  ≈ 1,300,000). Both of them can improve the purity of the as-prepared silver nanowires.

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