At radiolabeled APBA-FAPI for enhanced targeted-alpha therapy of glioma.

Fibroblast activation protein-α (FAPα) is highly expressed in tumor-associated cells and has become one of the most attractive targeting sites in cancer diagnosis and therapy. To ameliorate the rapid metabolism of FAPα inhibitor (FAPI), here, a multifunctional binding agent was introduced to simultaneously achieve At radiolabeling and tumor retention prolongation of corresponding radiolabeled drug. At-APBA-FAPI was successfully synthesized by conjugating At with the designed FAPI carrier in satisfactory radiochemical yield (>60 %).

Correlation of fundamental movement skills with health-related fitness elements in children and adolescents: A systematic review.

Objective: To examine the correlations between fundamental movement skills and health-related fitness elements (cardiopulmonary function, flexibility, body composition, muscle strength and endurance) in children and adolescents and investigate the evaluation methods and tools of fundamental movement skills and health-related fitness.

Methods: Six electronic databases (Web of Science, PubMed, ProQuest, Scopus, EBSCO and CNKI) were searched, and the research literature on the correlation between children's and adolescents' fundamental movement skills and health-related fitness published since 2002 was collected. The guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and the Consolidated Standards of Reporting Trials (CONSORT) statement were used to evaluate the quality of the literature, and the sources, samples, measurement methods, main results and statistical data of the study were analyzed, summarized and discussed.

Defining sports moral character and clarifying its related concepts.

This study examines the concept of sports moral character and clarifies the differences between it and related moral concepts in sports. The research is conceptual and uses the methods of a literature review and logical analysis. Sports moral character is shown to have the characteristics of practicality, growth, and integration.

Cancer screening and prevention education in standardized training residents: A cross-sectional survey in single center.

Background: Standardized residency training is an essential aspect of enhancing the ability of cancer prevention and screening of residents. The current study was performed to investigate tumor prevention, screening literacy and the training demands of standardized training residents and explore related influencing factors.

Methods: A cross-sectional survey was conducted among 320 residents of The First Hospital of Lanzhou University.

Clinical features, treatment and outcomes in patients with tracheal adenoid cystic carcinoma: a systematic literature review.

Background: Primary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in delayed presentation, and the therapeutic effects of multimodal treatment differ across individuals. This study aimed to review cases of TACC to identify clinical features, imaging modalities, treatment, and patient outcomes across follow-ups.

Formation mechanism of the nanostructure in laser streaming phenomenon.

Laser streaming is a phenomenon in which liquid streaming is driven directly from the laser through an in situ fabricated nanostructure. In this study, liquid streaming of a gold nanoparticle suspension driven by a pulsed laser was studied using a high-speed camera. The laser streaming formation time, streaming velocity, and relative energy conversion efficiency of laser streaming was measured for different nanoparticle concentrations, focal lens position, laser powers, and laser repetition rates.

Inhibition of the hypoxia-induced factor-1α and vascular endothelial growth factor expression through ginsenoside Rg3 in human gastric cancer cells.

Objective: The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human gastric cancer cells.

Materials And Methods: Human gastric cancer BGC823 cells were divided into the control group and experiment group, and expression levels of HIF-1α and VEGF were detected by immunocytochemistry and Western blot after cells were cultured under hypoxia for different durations.

Results: Under hypoxia, expression of HIF-1α and VEGF in human gastric cancer BGC823 cells showed an increasing trend, and that was remarkably lower in experiment group than in the control group after applying Rg3, which was obvious at 12 and 24 h (P < 0.

Outcomes and prognostic factors of patients with stage IB and IIA pancreatic cancer according to the 8 edition American Joint Committee on Cancer criteria.

Aim: To evaluate the changes in the 8 edition American Joint Committee on Cancer (AJCC) for defining stage IB and IIA pancreatic cancer and identify their prognostic factors.

Methods: Pancreatic cancer patients were selected from the Surveillance Epidemiology and End Results database (1973-2013). The enrolled patients were divided into IB and IIA groups based on tumor size according to the 8 edition AJCC criteria.