Publications by authors named "Guofeng Jia"

The commercialization of sodium-ion batteries has been hampered by the anode's performance. Carbon-based anodes have always had great application prospects, but traditional graphite anodes have great application limitations due to the inability of reversible insertion/de-insertion of sodium ions in them, while hard carbon materials have the high theoretical capacity, low reaction potential has received extensive attention in recent years. Nevertheless, the low first cycle Coulomb efficiency and rapid capacity decline of hard carbon materials limited its application.

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A dual substitution strategy is introduced to Co-free layered material LiNiMnO by partially replacing Li and Ni with Na and Al, respectively, to achieve a superior cathode material for lithium ion batteries. Na ion functions as a "pillar" and a " cationic barrier" in the lithium layer while Al ion plays an auxiliary role in stabilizing structure and lattice oxygen to improve the electrochemical performance and safety. The stability of lattice oxygen comes from the binding energy between the Ni and O, which is larger due to higher valences of Ni ions, along with a stronger Al-O bond in the crystal structure and the "cationic barrier" effect of Na ion at the high-charge.

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In this study, self-synthesized lithium trifluoro(perfluoro-tert-butyloxyl)borate (LiTFPFB) is combined with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) to formulate a novel 1 m dual-salt electrolyte, which contains lithium difluorophosphate (LiPO F ) additive and dominant carbonate solvents with low melting point and high boiling point. The addition of LiPO F into this novel dual-salt electrolyte dramatically improves cycleability and rate capability of a LiNi Mn Co O /Li (NMC/Li) battery, ranging from -40 to 90 °C. The NMC/Li batteries adopt a Li-metal anode with low thickness of 100 µm (even 50 µm) and a moderately high cathode mass loading level of 10 mg cm .

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Background: The herbicide sulfonylurea (SU) belongs to one of the most important class of herbicides worldwide. It is well known for its ecofriendly, extreme low toxicity towards mammals and ultralow dosage application. The original inventor, G Levitt, set out structure-activity relationship (SAR) guidelines for SU structural design to attain superhigh bioactivity.

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A new class of benzoxaborole β-lactamase inhibitors were designed and synthesized. 6-Aryloxy benzoxaborole 22 inhibited AmpC P99 and CMY-2 with K(i) values in the low nanomolar range. Compound 22 restored antibacterial activity of ceftazidime against Enterobacter cloacae P99 expressing AmpC, a class C β-lactamase enzyme.

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Aim: To investigate the cytotoxicity of the cytokine-induced killer (CIK) cells from the post-operation patients with primary hepatocellular carcinoma (HCC) to multidrug-resistant (MDR) cell of HCC both in vitro and in vivo.

Methods: A drug-resistant cell line was established by culturing human HCC cell line Bel-7402 in complete RPMI 1640 medium with increasing concentrations of adriamycin from 10 to 2,000 nmol/L. CIK cells were obtained by inducing the peripheral blood mononuclear cells with rhIFN-gamma, monoclonal anti-CD3 antibody, rhIL-1alpha as well as rhIL-2, which were added into the culture.

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The potential targeting of therapeutic bisphosphonate conjugates to bone metastatic lesions was evaluated in vivo in mice. A bisphosphonate conjugate with 5-fluorouracil was synthesized as a potential chemotherapy agent, and a bisphosphonate conjugate with diethylenetriaminepentaacetic acid (DTPA) was prepared as a potential carrier of cytotoxic radionuclides. The compounds are hypothesized to be able to deliver either high doses of radiation or a high concentration of chemotherapy agents at sites of increased osteoclastic activity in patients with bony metastases while exhibiting minimal toxicity to normal tissues.

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