Publications by authors named "Guofeng Bai"
MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction.
Animal Model Exp Med
August 2024
Article Synopsis
- * Researchers discovered that miR-106a inhibits essential processes such as cell proliferation, autophagy, and angiogenesis in venous endothelial cells while promoting cell death (apoptosis).
- * ATG7 was identified as a target gene of miR-106a, with findings suggesting that regulating this interaction could offer new therapeutic strategies for treating MI.
DNA methylation and long noncoding RNAs (lncRNAs) exhibit an indispensable role in follicular development. However, the specific mechanisms regarding lncRNAs mediated by DNA methylation in follicular development remain unclearly. In this study, we found that inhibiting the expression of DNMT1 promoted granulosa cells (GCs) apoptosis to inhibit follicular development.
View Article and Find Full Text PDFIn female mammals, the proliferation, apoptosis, and estradiol-17β (E2) secretion of granulosa cells (GCs) have come to decide the fate of follicles. DNA methylation and RSPO2 gene of Wnt signaling pathway have been reported to involve in the survival of GCs and follicular development. However, the molecular mechanisms for how DNA methylation regulates the expression of RSPO2 and participates in the follicular development are not clear.
View Article and Find Full Text PDF