The link between anger and reactive aggression: Insights into anger rumination.

This study examined the mediating role of anger rumination in the relationship between anger and reactive aggression and the potential of adaptive anger rumination in reducing reactive aggression. Study 1, a two-wave longitudinal survey of 177 Chinese adolescents, showed that anger rumination mediated the relationship between anger and reactive aggression. Study 2, an experimental study with 160 university students, showed that the self-distanced group had lower aggression than the self-immersed group, and anger rumination mediated the impact of anger on reactive aggression in only the self-immersed group.

Multicenter phase I dose escalation and expansion study of pyrotinib in combination with camrelizumab and chemotherapy as first-line treatment for HER2-positive advanced gastric and gastroesophageal junction adenocarcinoma.

Background: Pembrolizumab plus trastuzumab and chemotherapy showed remarkable efficacy as first-line therapy for advanced HER2-positive gastric cancer. Pyrotinib is an irreversible pan-HER inhibitor. This single-arm, open-label phase 1 dose-escalation (1a) and expansion (1b) study investigated camrelizumab, an anti-PD-1 antibody, plus pyrotinib and chemotherapy as first-line treatment for advanced HER2-positive gastric and gastroesophageal junction (G/GEJ) adenocarcinoma.

Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches.

Colorectal cancer (CRC) is one of the universally established cancers with a higher incidence rate. Novel progression toward cancer prevention and cancer care among countries in transition should be considered seriously for controlling CRC. Hence, several cutting edge technologies are ongoing for high performance cancer therapeutics over the past few decades.

Effects of five years conservation tillage for hedging against drought, stabilizing maize yield, and improving soil environment in the drylands of northern China.

Continuous tillage cultivation positioning trials can provide the basis for maintaining soil health, improving resource utilization efficiency and crop productivity, and achieving sustainable agricultural development. In this study, changes in soil stability and water-holding capacity characteristics were measured under different tillage cultivations from a multi-year microscopic perspective and analyzed to evaluate selected key indicators. Continuous monitoring of rainfall utilization efficiency and yield was carried out for five years.

Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.

Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely limited. Here, we develop a DNAzyme-based method to detect DNA adduct damage for toxicity assessment of drugs and chemicals.

Machiavellianism and learning-related subjective well-being among Chinese senior high school students: A moderated mediation model.

Based on the life history theory and broadening construction theory, the study aimed to investigate the influence of Machiavellianism on the learning-related subjective well-being and the underlying mechanism, 582 Chinese senior high school students (16.8 ± 0.9 years old) including 289 girls (48.

Simultaneous detection of acetaminophen, catechol and hydroquinone using a graphene-assisted electrochemical sensor.

Simple, rapid and sensitive analysis of drug-derived pollutants is critically valuable for environmental monitoring. Here, taking acetaminophen, hydroquinone and catechol as a study example, a sensor based on an ITO/APTES/r-GO@Au electrode was developed for separate and simultaneous determination of phenolic pollutants. ITO electrodes that are modified with 3-aminopropyltriethoxysilane (APTES), graphene (GO) and Au nanoparticles (Au NPs) can significantly enhance the electronic transport of phenolic pollutants at the electrode surface.

Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of s in the Treatment of Oral Lichen Planus.

Objective: Oral lichen planus (OLP) is the most common potentially malignant disorder of the oral cavity. This study aimed to investigate the mechanism of action of in the treatment of OLP and provides a theoretical support for improving current treatment regimens for OLP.

Methods: The active components and therapeutic targets of were predicted and screened using the TCMSP, SymMap, PubMed, HIT 2.

A Mean-Field Game Control for Large-Scale Swarm Formation Flight in Dense Environments.

As an important part of cyberphysical systems (CPSs), multiple aerial drone systems are widely used in various scenarios, and research scenarios are becoming increasingly complex. However, planning strategies for the formation flying of aerial swarms in dense environments typically lack the capability of large-scale breakthrough because the amount of communication and computation required for swarm control grows exponentially with scale. To address this deficiency, we present a mean-field game (MFG) control-based method that ensures collision-free trajectory generation for the formation flight of a large-scale swarm.

Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids.

Pyrrolizidine alkaloids (PAs) and PA N-oxides are hepatotoxic natural products, produced by over 6000 plant species worldwide. However, an unmet need remains for confirmative measurement of PAs in routine clinical tests. Here, we develop a visual, easy-to-use, and economic mesoporous silica-electrochemiluminescence (MPS-ECL) sensor for point-of-care (POC) testing of PAs, utilizing MPS's amplification effect on positive ions.

Electrogenerated chemiluminescence of a Ru(bpy) /arginine system: a specific and sensitive detection of acetaminophen.

Ru(bpy)Cl/TPrA is a prominent and widely used ECL system in analytical science. However, the co-reactant TPrA restricts the variety of applications because of its toxicity, volatility, and high cost. Here, we use arginine (Arg) as an alternative co-reactant for Ru(bpy) by taking advantage of its low cost, non-toxicity, and biocompatibility.

Mesoporous silica-mediated controllable electrochemiluminescence quenching for immunosensor with simplicity, sensitivity and tunable detection range.

Straightforward and accurate measurement of medical biomarkers is of essential importance in clinical diagnostics and treatments. However, the major challenge is the diversity in dynamic range of different biomarkers ranging from pg mL to μg mL in various body fluids and tissues among patients. Here, we develop a mesoporous silica (MS)-mediated controllable electrochemiluminescence (ECL) quenching of immunosensor that allows accurate immunoassays with simplicity, sensitivity and tunable sensing range.

Microplastic Pollution in China, an Invisible Threat Exacerbated by Food Delivery Services.

With the rapid development and democratization of the internet and smart phone industry, online food delivery services have become increasingly popular all over the globe, namely in China. One of the unfortunate drawbacks of these delivery services is that they mainly use single-use plastics as food packaging, therefore generating large amounts of disposable food containers to meet demand. Such plastic containers reach the end of their service life after a single meal, and are then discarded as plastic waste.

PDK-1 mediated Hippo-YAP-IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells.

Pyruvate dehydrogenase kinase-1 (PDK-1), a gatekeeper enzyme, was involved in cancer progression, such as tumor angiogenesis, cell survival, and growth. Recent evidence indicated that PDK-1 may be involved in lung cancer, however, the function and underlying mechanism of PDK-1 is remaining unclear. In the present study, our aim was to investigate the role and mechanisms of PDK-1 in human non-small cell lung cancer (NSCLC) cells.

miR-143 suppresses the osteogenic differentiation of dental pulp stem cells by inactivation of NF-κB signaling pathway via targeting TNF-α.

Background: Dental pulp stem cells (DPSCs) are multipotent and play an important role in repairing damaged and/or defective dentinogenesis/osteogenesis. Recent studies have documented the implication of miR-143 in osteogenic differentiation of DPSCs. Nevertheless, the detailed mechanisms of miR-143 involved in the osteogenic differentiation of DPSCs remain to be further elaborated.

Measuring generalised expectancies for negative mood regulation in China: The Chinese language Negative Mood Regulation scale.

Negative mood regulation expectancies (NMRE) represent people's confidence that they can alleviate their negative affect or induce a positive emotional state through thought or action. NMRE predict coping behaviour and mood outcomes for individuals under stress. Since 1990, much research documents the reliability and validity of the English language Negative Mood Regulation (NMR) scale as a measure of NMRE.

Overview of Cantharidin and its Analogues.

Background: Cantharidin has been categorized as highly toxicant in Chinese medicine. But cantharidin can efficiently treat different types of diseases, such as molluscum contagiosum. While cantharidin is quite useful, unfortunately, due to its side effects, increasing regulations have limited access to this useful therapeutic option.

Dual emission of Ce ,Mn -coactivated Ca YNa(PO ) F via energy transfer: a single component white/yellow-emitting phosphor.

A series of Ce ,Mn -coactivated Ca YNa(PO ) F phosphors were synthesized via a traditional solid-state reaction under a reductive atmosphere. X-Ray powder diffraction was used to confirm that the crystal structure and diffraction peaks of Ce /Mn -doped samples matched well with the standard data. A spectral overlap between the emission band of Ce and the excitation band of Mn suggested the occurrence of energy transfer from Ce to Mn .

Color-tunable emission and energy transfer investigation in SrY(PO):Ce,Tb phosphors for white LEDs.

A novel color-tunable phosphor SrY(PO):Ce,Tb was synthesized through solid-state reaction method. Several techniques, such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy, were used to investigate the obtained phosphors. Results of luminescence spectra and decay time measurements revealed that an efficient energy transfer occurred from Ce to Tb via a dipole-dipole mechanism, where Ce exhibited a strong excitation band in the near-ultraviolet region.

Luminescence and energy transfer of the color-tunable phosphor Li₆Gd(BO₃)₃:Tb³⁺/Bi³⁺, Eu³⁺.

Bi(3+)/Tb(3+), Eu(3+) co-doped Li6Gd(BO3)3 (LGBO) phosphors were synthesized via a traditional solid-state method. Phase purity was investigated using X-ray diffraction, absorption strength of the phosphors were investigated by UV-vis absorption spectra, and the photoluminescence properties of the phosphors were studied systematically. Results showed that the emission intensity of Bi(3+), Eu(3+) co-doped LBOG was 2.

Focal adhesion kinase activation is required for TNF-α-induced production of matrix metalloproteinase-2 and proinflammatory cytokines in cultured human periodontal ligament fibroblasts.

Since focal adhesion kinase (FAK) was proposed as a mediator of the inflammatory response, we have investigated the role of this molecule in the release of inflammatory cytokines by cultured human periodontal ligament fibroblasts (HPDLFs), cells that are thought to be important in the patient's response to periodontal infection. Human periodontal ligament fibroblasts were stimulated by tumor necrosis factor alpha (TNF-α) and its effects on interleukin (IL)-6 and IL-8 release were measured by ELISA. Expression of matrix metalloproteinase 2 (MMP-2) protein was analysed by western blotting.

Luminescence and energy transfer of color-tunable Li6Gd(BO3)3:Ce(3+), Tb(3+) phosphor.

A series of novel color-tunable phosphors of Ce(3+), Tb(3+)-codoped Li6Gd(BO3)3 was synthesized through a classic solid-state reaction. The color of these phosphors changes from blue to green by adjusting the ratio of Ce(3+) to Tb(3+). The photoluminescence properties of the synthesized phosphors were investigated, and several major emission bands that belong to Ce(3+) and Tb(3+) ions were irradiated with near ultraviolet light.

Analysis on the formation condition of the algae-induced odorous black water agglomerate.

The algae-induced odorous black water agglomerate (OBWA) is a phenomenon in which water turns black and emits odorous gas. It is an ecological and environmental problem that has occurred several times in Taihu, a large eutrophic shallow lake in China. In this study, the collected eutrophic water with different algae densities was used to simulate OBWA.