Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2 (EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) syndrome comprising cerebellar hypoplasia and motor dysfunction. How EFTUD2 deficiency contributes to these symptoms remains elusive. Here, we demonstrate that specific ablation of Eftud2 in cerebellar Purkinje cells (PCs) in mice results in severe ferroptosis, PC degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with MFDM.

Effects of different types of flame-retardant treatment on the flame performance of polyurethane/wood-flour composites.

To improve the flammability of foamed polyurethane/wood-flour composites (FWPC), ammonium polyphosphate (APP) was used as a flame retardant to modified FWPC. The effects of different flame treatment processes on flame performance, smoke suppression, thermal property, and surface micrographs of flame retardant FWPC were investigated. The results showed that FWPC with the addition or impregnation process both improved the combustion behaviors.

O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation.

Purkinje cells (PCs), as a unique type of neurons output from the cerebellar cortex, are essential for the development and physiological function of the cerebellum. However, the intricate mechanisms underlying the maintenance of Purkinje cells are unclear. The O-GlcNAcylation (O-GlcNAc) of proteins is an emerging regulator of brain function that maintains normal development and neuronal circuity.

Fasting blood glucose-to-glycated hemoglobin ratio for evaluating clinical outcomes in patients with ischemic stroke.

Background: Stress hyperglycemia frequently occurs in patients with acute ischemic stroke (AIS). The influence of stress hyperglycemia on the outcomes of patients with AIS remains ambiguous.

Methods: Data from our institution on patients with AIS between June 2020 and June 2021 were retrospectively analyzed.

Spliceosomal GTPase Eftud2 regulates microglial activation and polarization.

Elongation factor Tu GTP binding domain protein 2 (Eftud2) is a spliceosomal GTPase that serves as an innate immune modulator restricting virus infection. Microglia are the resident innate immune cells and the key players of immune response in the central nervous system. However, the role of Eftud2 in microglia has not been reported.

In Situ Polymerization and Flame Retardant Mechanism of Bio-Based Nitrogen and Phosphorus Macromolecular Flame Retardant in Plywood.

To improve the flame retardant performance of plywood and reduce the reagent loss and moisture absorption of the flame retardant, a bio-based supramolecular flame retardant is prepared by vacuum-pressure impregnation and high-temperature in situ polymerization in plywood. The best value of bonding strength appears at 170 °C, and the limiting oxygen index (LOI) of 170BF-B plywood is 42.3%.

Disruption of rack1 suppresses SHH-type medulloblastoma formation in mice.

Introduction: Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH-MB) is one of the major subtypes of MB in the clinic. However, the molecular mechanisms underlying MB tumorigenesis are still not fully understood.

VDAC1 is regulated by BRD4 and contributes to JQ1 resistance in breast cancer.

Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. However, the specific biological function and regulatory mechanism of VDAC1 in breast cancer remains unclear.