Spectrally tunable near-infrared photoluminescence in MPO:Cr (M = Al, Ga, In) phosphate phosphors.

Modulation of the octahedral crystal field environment of Cr is an effective approach to achieve tunable emission. Here, we prepared a series of broadband MPO:Cr (M = Al, Ga, In) near-infrared (NIR) phosphors, and cubic AlPO:Cr (APO-c:Cr) and monoclinic AlPO:Cr (APO-m:Cr) phosphors were prepared by controlling the synthesis temperature. The emission wavelength was tuned from 787 nm for APO-c:Cr to 894 nm for monoclinic InPO:Cr (IPO:Cr) by regulating the M ion and reducing the crystal field intensity.

Broadband Near-Infrared Luminescence in Garnet YGaMgSiO: Cr Phosphors.

Broadband near-infrared (NIR) phosphors are the critical component of phosphor converted NIR light-emitting diode (LED) light sources. However, there are still a lack of NIR phosphors with excellent external quantum efficiency (EQE) and thermal stability. Here, we report a highly efficient broadband NIR phosphor YGaMgSiO: Cr.

Rapid Discovery of Efficient Long-Wavelength Emission Garnet:Cr NIR Phosphors via Multi-Objective Optimization.

High-efficiency long-wavelength emission near-infrared (NIR) phosphors are the key to next-generation LED light sources. However, high-efficiency phosphors usually exhibit narrow-band emission at shorter wavelengths due to the crystal field intensity. In this paper, we utilize multi-objective optimization to discover the NIR phosphor GdMgAlGaGeO:0.

Multiobjective Machine Learning-Assisted Discovery of a Novel Cyan-Green Garnet: Ce Phosphors with Excellent Thermal Stability.

Ce-doped garnet phosphors play an important role in the white light-emitting diode (LED) family. In the past years, a lot of trial-and-error experiments guided by experience to discover phosphors suitable for white LEDs have been presented. The working temperature of phosphors may reach 200 °C in white LEDs, and so, the exploration of phosphors with excellent thermal stability at the desired wavelength continues to be a challenge.

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study.

Background: We aimed to explore the association between urinary alpha1-microglobulin (A1M) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population.

Study: We performed a cross-sectional study among 2,215 Chinese who attended their annual health examination at First Affiliated Hospital, College of Medicine, Zhejiang University. Urinary A1M-creatinine ratio and other clinical and laboratory parameters were measured.

HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs.

Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, the specific mechanism by which it promotes the evolution of gastric cancer (GC) is poorly understood.In this study, we sought to investigate the role of HOXB7 in GC by assessing HOXB7 expression in patient tissue and its correlation to clinical characteristics.

Association between red cell distribution width and acute pancreatitis: a cross-sectional study.

Objective: We investigated whether red cell distribution width (RDW) was associated with mortality in patients with acute pancreatitis (AP).

Design: A cross-sectional study.

Setting: Patients with AP were recruited in the emergency department and healthy individuals were recruited in healthcare centre in the First Affiliated Hospital of Zhejiang University.

Effect of pre-analytical variables on coagulation tests in hepatitis B patients.

To determine the effects of various pre-analytical variables on the values of activated partial thromboplastin time (APTT), D-dimers, fibrinogen (Fbg), prothrombin time (PT) and thrombin time (TT). Samples from 120 hepatitis B patients were divided into three groups based on storage time (0-24 h), mechanical agitation and separation into plasma. In all groups, samples were stored at room temperature and 4°C.

Efficacy of combined therapy in patients with hepatitis B virus-related decompensated cirrhosis.

Aim: To investigate the efficacy and safety of combined de novo lamivudine (LAM) and adefovir dipivoxil (ADV) therapy in hepatitis B virus (HBV)-related decompensated liver cirrhosis patients.

Methods: One hundred and forty patients with HBV-related decompensated cirrhosis were recruited, 70 patients were treated with combined LAM and ADV de novo therapy, and the other 70 patients were treated with LAM alone as controls. The follow-up period was 144 wk.

Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B.

Objective: To investigate whether Toll-like receptor (TLR) 7 and TLR9-mediated interferon α (IFN-α) production in plasmacytoid dendritic cells (pDCs) is compromised in patients with chronic hepatitis B virus (HBV) infection.

Materials And Methods: Peripheral blood mononuclear cells (PBMCs) were prepared from 32 chronic HBV patients and 13 healthy volunteers, and treated with loxoribine or cytidine phosphate guanosine (CpG) oligodeoxynucleotides (ODN). Interferon α in the supernatant was measured by sandwich ELISA.

The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans.

Objectives: Determine xanthine oxidase (XO) activity and oxidative-stress parameters in human acute paraquat poisoning.

Design And Methods: Twnty-five patients and 26 healthy control participants were recruited. Serum XO, superoxide dismutase (SOD), Glutathione (GSH) and malondialdehyde (MDA) were determined by spectrophotometric methods.

Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment.

Background: Accumulating evidence supports the theory that expression of CD127 on CD8 T cells during the process of antiviral immune response indicates a subset of effect CD8 T cells that successfully develop into fully protective memory. CD8 T cells expression of CD127 may be used as a predictor to evaluate disease status in chronic viral infection. The aim of this study was to investigate the CD127 expression level on different subsets of CD8 T cell and explore the relationship between CD127 expression on CD8 memory T cells and serum hepatitis B virus (HBV) DNA and hepatitis B e antigen (HBeAg) levels in patients with chronic hepatitis B (CHB).

Efficacy of telbivudine in HBeAg-positive chronic hepatitis B patients with high baseline ALT levels.

Aim: To evaluate the efficacy and safety of telbivudine (LDT) in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients who have high baseline alanine aminotransferase (ALT) levels between 10 and 20 times the upper limit of normal.

Methods: Forty HBeAg-positive CHB patients with high baseline ALT levels between 10 and 20 times the upper limit of normal were enrolled and received LDT monotherapy for 52 wk. Another forty patients with baseline ALT levels between 2 and 10 times the upper limit of normal were included as controls.

Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD.

Background And Aim: Accumulating evidence supports the effects of miRNA in lipid metabolism, providing a potential linkage between certain miRNA and non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the miRNA expression pattern in a steatotic L02 cell model and explore the function of certain miRNA target pairs.

Methods: The cell model was established by culturing L02 cells with a high concentration of free fatty acid.

Hepatocytes treated with HBV X protein as cytotoxic effectors kill primary hepatocytes by TNF-alpha-related apoptosis-induced ligand-mediated mechanism.

Objective: To investigate the effect of HBV X protein (HBX) on TNF-alpha-related apoptosis-induced ligand (TRAIL) expression in HepG2 cells, and observe death of primary hepatocytes induced by HBX-transfected HepG2 cells.

Methods: Western blot was used to detect the TRAIL expression in HepG2 cells transfected with mammalian expression plasmid pSG5UTPL-HBX. The reverse transcription-PCR was used to observe TRAIL mRNA transcription stimulated by HBX protein, and chromium release assay was used to detect death of primary hepatocyte induced by HBX-transfected HepG2 cells.

Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohepatitis in rats.

Aim: To investigate whether increased intestinal permeability contributes to the pathogenesis and progress of nonalcoholic steatohepatitis by observing its dynamic change in rat models.

Methods: Rat models of nonalcoholic steatohepatitis were established by giving a fat-rich diet. The rats were sacrificed at wk 8, 12 and 16 during the study.

Monitoring the level of serum paraoxonase 1 activity in liver transplantation patients.

Background: Paraoxonase 1(PON1) is an ester hydrolase in serum and in the liver. Studies have suggested that PON1 measurement to the current battery of tests may improve the evaluation of chronic liver diseases. The aim of this study was to investigate the clinical significance of monitoring the level of serum PON1 activity in liver transplantation patients.

[Involvement of TRAIL up-regulation of CD4+, CD8+ T cells in liver injury in chronic hepatitis B].

Objective: To describe a novel mechanism for TRAIL up-regulation of CD4+, CD8+ T cells to participate in the pathophysiological process in patients with chronic hepatitis B (CHB).

Methods: The serum levels of soluble TRAIL (sTRAIL), IFN-gamma and membrane bound TRAIL expression on peripheral leucocytes from 58 CHB patients were examined by ELISA and flow cytometry respectively. The levels of TRAIL were compared with the baseline levels of 15 healthy controls, and correlation analysis were performed between ALT, TBil and PT, morphological change in hepatic tissues.