Publications by authors named "Guobin Li"

Purpose: Magnetic resonance imaging (MRI) refers to one of the critical image modalities for diagnosis, whereas its long acquisition time limits its application. In this study, the aim was to investigate whether deep learning-based techniques are capable of using the common information in different MRI sequences to reduce the scan time of the most time-consuming sequences while maintaining the image quality.

Method: Fully sampled T1-FLAIR, T2-FLAIR, and T2WI brain MRI raw data originated from 217 patients and 105 healthy subjects.

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Background Cardiac MRI at 5 T has recently become available and potentially improves tissue contrast enhancement at gadolinium chelate-enhanced T1-weighted imaging. Purpose To evaluate the feasibility of 5-T myocardial late gadolinium enhancement (LGE) MRI in assessing myocardial fibrosis by comparing image quality and LGE quantification with reference-standard 3-T myocardial LGE MRI. Materials and Methods Consecutive patients with confirmed myocardial fibrosis on previous 3-T MRI scans between January 2023 and July 2023 prospectively underwent follow-up imaging from August 2023 to November 2023.

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Article Synopsis
  • Coronary MR angiography (CMRA) at 5 T potentially outperforms 3 T due to better image quality and sensitivity in detecting coronary artery disease (CAD).
  • The study included 79 patients and 8 volunteers, comparing 5-T and 3-T imaging techniques, with 5 T showing higher per-segment sensitivity for coronary artery calcium and better consistency with coronary CT angiography (CCTA).
  • Overall, 5-T noncontrast CMRA could be a promising clinical tool for diagnosing CAD, though the specific diagnostic performance metrics varied between 5 T and 3 T.
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  • T2-weighted 2D fast spin echo is the standard for pelvic MR imaging but suffers from motion artifacts due to peristalsis, resulting in challenges and the need for patient discomfort because of preparation methods.
  • A new dynamic imaging approach is introduced that allows imaging without any prior patient preparation, using rapid data collection and advanced reconstruction techniques to minimize motion issues.
  • Experimental results show that this innovative method significantly reduces motion artifacts and improves the clarity of structural details compared to traditional static imaging techniques.
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  • * In wild-type tomato plants, SlGSTU43 expression increases under high salt conditions, promoting the scavenging of reactive oxygen species (ROS) and influencing lignin biosynthesis through interaction with SlCOMT2.
  • * Silencing transcription factors SlMYB71 and SlWRKY8 reduces GST activity and lignin content in tomatoes, making them more susceptible to salt stress, highlighting the complex regulation of salt tolerance mechanisms involving GSTs.
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Thermosensitive transient receptor potential (thermoTRP) ion channels can transduce external thermal stimuli to neural electrical signals, allowing organisms to detect and respond to changes in environmental temperature. Reproducing such ionic machinery holds promise for advancing the design of highly efficient low-grade thermal energy harvesters and ultrasensitive thermal sensors. However, there still exist challenges for artificial nanofluidic architectures to achieve comparable thermoelectric performance.

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Saline-alkali stress is a widely distributed abiotic stress that severely limits plant growth. γ-Aminobutyric acid (GABA) accumulates rapidly in plants under saline-alkali stress, but the underlying molecular mechanisms and associated regulatory networks remain unclear. Here, we report a MYB-like protein, I-box binding factor (SlMYBI), which positively regulates saline-alkali tolerance through induced GABA accumulation by directly modulating the glutamate decarboxylase (GAD) gene SlGAD1 in tomato (Solanum lycopersicum L.

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The aberrant activation of FGFR acts as a potent driver of multiple types of human cancers. Despite the development of several conventional small-molecular FGFR inhibitors, their clinical efficacy is largely compromised because of low selectivity and side effects. In this study, we report the selective FGFR1/2-targeting proteolysis-targeting chimera BR-cpd7 that displays significant isoform specificity to FGFR1/2 with half maximal degradation concentration values around 10 nmol/L while sparing FGFR3.

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Objective: The purpose of this work was to develop an anti-CAT-SYI immunoglobulin Y (IgY) antibody that targeted both GtfB (glucosyltransferase B) and GbpB (glucan-binding protein B) and test its anticaries properties in rats.

Methods: A new CAT-SYI fusion gene was created utilising functional DNA fragments from the GtfB and GbpB genes. The recombinant antigens, comprising the fused CAT-SYI antigen, GtfB, and GbpB, were expressed and purified using a prokaryotic expression and purification system.

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The aberrant activation of fibroblast growth factor receptor (FGFR) acts as a potent driver of multiple types of human cancers. Despite the development of several conventional small-molecular FGFR inhibitors, their clinical efficacy is largely compromised due to low selectivity and side effects. Here, we report the selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC), BR-cpd7 that displays significant isoform specificity to FGFR1/2 with DC50 values around 10 nM, while sparing FGFR3.

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Saline-alkali is an important abiotic stressor influencing tomato production. Exogenous methyl jasmonate (MeJA) is well known to increase tomato resistance to a variety of stresses, although its exact mechanism is yet unknown. In this study we confirmed that 22.

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Modern tomatoes produce colorful mature fruits, but many wild tomato ancestors form green or gray green ripe fruits. Here, tomato cultivar 'Lvbaoshi' (LBS) that produces green ripe fruits was found to contain three recessive loci responsible for fruit development. The colorless peel of LBS fruits was caused by a 603 bp deletion in the promoter of SlMYB12.

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Saline-alkali stress is an important abiotic stress factor affecting tomato (Solanum lycopersicum L.) plant growth. Although the involvement of the tomato SlWRKY gene family in responses to saline-alkali stress has been well established, the mechanism underlying resistance to saline-alkali stress remains unclear.

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DC1 (Divergent C1) domain proteins are a new class of proteins that have been discovered in recent years, which play an important role in plant growth, development, and stress response. In order to better study the distribution and function of DC1 domain proteins in tomatoes, a genome-wide identification was conducted. It was found that there are twenty-one DC1 domain protein genes distributed on nine chromosomes of tomatoes, named .

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While deep learning has found widespread utility in gearbox fault diagnosis, its direct application to wind turbine gearboxes encounters significant hurdles. Disparities in data distribution across a spectrum of operating conditions for wind turbines result in a marked decrease in diagnostic accuracy. In response, this study introduces a tailored dynamic conditional adversarial domain adaptation model for fault diagnosis in wind turbine gearboxes amidst cross-condition scenarios.

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Flowering time, an important factor in plant adaptability and genetic improvement, is regulated by various genes in tomato (Solanum lycopersicum). In this study, we characterized a tomato mutant, EARLY FLOWERING (EF), that developed flowers much earlier than its parental control. EF is a dominant gain-of-function allele with a T-DNA inserted 139 bp downstream of the stop codon of FANTASTIC FOUR 1/2c (FAF1/2c).

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Article Synopsis
  • - The study introduces a hybrid deep-learning and iterative reconstruction (hybrid DL-IR) framework designed for quick and effective medical image generation in MRI, PET, and CT scans.
  • - In MRI, the framework was tested on 6,066 cases, successfully reconstructing images from under-sampled data, reducing scan time to as short as 10-100 seconds.
  • - It also showed effectiveness in low-dose CT scans, managing to reduce radiation exposure significantly while maintaining image quality, as well as in PET scans where even small tumor lesions were accurately reconstructed.
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Purpose: To propose an acceleration method for 3D variable flip-angle (VFA) T mapping based on a technique called shift undersampling improves parametric mapping efficiency and resolution (SUPER).

Methods: The proposed method incorporates strategies of SUPER, controlled aliasing in volumetric parallel imaging (CAIPIRINHA), and total variation-based regularization to accelerate 3D VFA T mapping. The k-space sampling grid of CAIPIRINHA is internally undersampled with SUPER along the contrast dimension.

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Multiple Gretchen Hagen 3 (GH3) genes have been implicated in a range of processes in plant growth and development through their roles in maintaining hormonal homeostasis. However, there has only been limited study on the functions of GH3 genes in tomato (Solanum lycopersicum). In this work, we investigated the important function of SlGH3.

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Osteoporosis and sarcopenia (termed "Osteosarcopenia"), the twin-aging diseases, are major contributors to reduced bone mass and muscle weakness in the elderly population. Connexin 43 (Cx43) in osteocytes has been previously reported to play vital roles in bone homeostasis and muscle function in mature mice. The Cx43-formed gap junctions (GJs) and hemichannels (HCs) in osteocytes are important portals for the exchange of small molecules in cell-to-cell and cell-to-extracellular matrix, respectively.

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Endogenous spermidine can improve the resistance of plants to saline-alkali stress. SlSPDS1 and SlSPDS2 are the main spermidine synthase (SPDS) genes in tomatoes. In comparison with SlSPDS1, SlSPDS2 plays an important role in wild-type tomato seedling under saline-alkali stress.

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Objective: To identify the relation of microvascular density (MVD) to the early postoperative recurrence and metastasis of T1 esophageal squamous cell carcinoma, and to determine whether MVD could be a prognostic predictor of esophageal squamous cell carcinoma.

Methods: Patients with T1 esophageal squamous cell carcinoma were enrolled. Immunohistochemistry with primary antibody against CD-34 was performed to count MVD.

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Path planning for wheeled mobile robots on partially known uneven terrain is an open challenge since robot motions can be strongly influenced by terrain with incomplete environmental information such as locally detected obstacles and impassable terrain areas. This paper proposes a hierarchical path planning approach for a wheeled robot to move in a partially known uneven terrain. We first model the partially known uneven terrain environment respecting the terrain features, including the slope, step, and unevenness.

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Objective: Currently, the treatment of spontaneous intracerebral hemorrhage (sICH) is limiting, especially in patients with midline shift and supratentorial hemorrhage. Here, we investigated the clinical value of minimally invasive surgery (MIS) in patients with midline shift and supratentorial sICH by observing the consciousness state, midline shift, and short-term mortality.

Methods: A total of 124 supratentorial sICH patients with midline shift, hematoma volume >30 mL and <150 mL were included in this study.

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Synopsis of recent research by authors named "Guobin Li"

  • - Guobin Li's recent research spans various fields, including advanced imaging techniques for coronary MR angiography, innovative approaches to enhance MRI imaging in clinical settings, and the development of nanofluidic thermoelectric devices, showcasing his interdisciplinary expertise.
  • - His studies on the use of 5-T MR technology highlight the potential for improved diagnostic performance over traditional methods, while his work on T2-weighted imaging addresses significant challenges in pelvic MRI related to motion artifacts.
  • - In the realm of plant science, Li investigates the molecular mechanisms for enhancing saline-alkali tolerance in tomatoes, revealing the role of specific proteins and regulatory pathways, thereby contributing to agricultural resilience against abiotic stress.