The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.

Objective: To screen out potential biomarkers by analyzing fundamental nutrients in the bronchoalveolar lavage fluid (BALF) before confirming the lung cancer.

Methods: In this study, 44 patients were enrolled with clinical information. The concentrations of 23 amino acids and 35 carnitines in their BALF were detected with the high-performance liquid chromatography-mass spectrometry (HPLC-MS).

Heparin coated meta-organic framework co-delivering doxorubicin and quercetin for effective chemotherapy of lung carcinoma.

Objective: To develop and evaluate a drug delivery system (DDS) capable of targeting cancer cells while at the same time delivering two chemotherapeutic agents to overcome multidrug resistance (MDR).

Methods: This study developed a DDS composed of heparin (HA)-coated meta-organic framework (MOF) nanoparticles (HM) designed to deliver doxorubicin (Dox) and quercetin (Que). A range of and studies were conducted to determine the characteristics of the HM/Dox/Que nanoparticles, their ability to produce cytotoxic effects in Dox-resistant A549/Dox cells and target and treat solid tumours in a mouse xenograft model of human lung carcinoma.

[Continuous observation of canal aberrations in S-shaped simulated root canal prepared by hand-used ProTaper files].

Purpose: To observe the formation of canal aberrations in S-shaped root canals prepared by every file of hand-used ProTaper.

Methods: Fifteen S-shaped simulated resin root canals were selected. Each root canal was prepared by every file of hand-used ProTaper following the manufacturer instruction.

[Investigation of influence on apical sealability generated by root canal sealer placement].

Objective: To investigate the influence of sealer placement on apical sealability in root canal treatment.

Methods: 100 extracted single root canal teeth were selected. All canals were prepared by manual Protaper instrument in a step-back way.

[The biomechanical study of craniovertebral junction fixation with posterior transarticular screw].

Objective: To evaluate the stability of biomechanics of occipitoatlantoaxial reconstruction with transarticular screw fixation.

Methods: Twelve fresh human cadaveric occipitocervical spine specimens were mounted in a custom-designed, spine-testing machine that applied pure moments while recording the three-dimensional angular movement at occiput (Oc)-C(1) and C(1 - 2) segments. The specimens were tested under seven different conditions: the intact (intact group), the occipitoatlantoaxial instability (Destabilized group), fixation with Ti-cable plus bone graft group (cable + graf group), fixation with the transarticular fixation (CTS group), fixation with SUMMIT occitocervical spinal fixation system (SUMMIT group), fixation with transarticular screw plus bone graft (CTS + graf group), and fixation with SMMIT system and plus graft group (SUMMIT + graf group).