Precise manipulation of iron spin states in single-atom catalytic membranes for singlet oxygen selective production.

Heterogeneous single-atom catalysts are attracting substantial attention for selectively generating singlet oxygen (O). However, precise manipulation of atom coordination structures remains challenging. Here, the fine coordination structure of iron single-atom carbon-nitride catalysts (Fe-CNs) was manipulated by precisely tuning the heating rate with 1 °C min difference.

Expert consensus on the off-label use in China of drugs for rare hematologic diseases (2024 edition).

Drug package inserts are a crucial foundation for clinical medication practices and serve as the legal basis for guiding rational drug use and ensuring patient safety and efficacy. As rare disease treatments evolve, current package inserts often need to meet the clinical requirements for treating such conditions, frequently resulting in off-label drug use. This consensus is derived from discussions between Guangdong Pharmaceutical Association Hematologic Rare Diseases Group experts.

Tailoring Infrared Light-Molecule Coupling for Highly Sensitive Cortisol Detection Employing Aptamer-Conjugated Gold Nanonails.

Chemically synthesized gold nanoantennas possess easy processability, low cost, and suitability for large-area fabrication, making them advantageous for surface-enhanced infrared (SEIRA) biosensing. Nevertheless, current gold nanoantennas face challenges with limited enhancement of biomolecular signals that hinder their practical applications. Here, we demonstrate that the coupling rate between antennas and molecules critically impacts the enhancement of molecular signals based on temporal coupled mode theory.

Research on influenza epidemic and clinical characteristics based on influenza research database.

Objective: To compare the epidemic trends of different types of influenza viruses and the clinical characteristics of patients, so as to provide reference for influenza prevention and control.

Methods: This was descriptive research. The human monitoring data collected from the Influenza Research Database (IRD) from 2006 to 2016 were used to descriptively analyze the distribution of influenza viruses in terms of time, geography, gender and age.

An AI Agent for Fully Automated Multi-Omic Analyses.

With the fast-growing and evolving omics data, the demand for streamlined and adaptable tools to handle bioinformatics analysis continues to grow. In response to this need, Automated Bioinformatics Analysis (AutoBA) is introduced, an autonomous AI agent designed explicitly for fully automated multi-omic analyses based on large language models (LLMs). AutoBA simplifies the analytical process by requiring minimal user input while delivering detailed step-by-step plans for various bioinformatics tasks.

Intelligent Forest Hospital as a New Management System for Hospital-Acquired Infection Control.

Hospital-acquired infection (HAI) is a significant global health concern, elevating the risks of morbidity and imposing a substantial socioeconomic burden. To enhance the management of HAI, particularly in the aftermath of the coronavirus disease 2019 (COVID-19) pandemic, the Guangdong Second Provincial General Hospital (GD2H) has launched a new system called Intelligent Forest Hospital (IFH). Leveraging advancements in artificial intelligence, 5G technology, and cloud networking, the IFH implements customized indoor air quality (IAQ) control strategies tailored to different medical settings.

Relationship between short-term exposure to sulfur dioxide and emergency ambulance dispatches due to cardiovascular disease.

Background: The relationship between sulfur dioxide (SO) and cardiovascular disease (CVD) remains inconclusive. We aimed to clarify the association between short-term exposure to SO and emergency ambulance dispatches (EADs) due to CVD.

Methods: We collected daily data on the number of EADs due to CVD, air pollutants, and meteorological factors between October 2013 and June 2018 in Guangzhou, China.

Distinct bacterial signature in the raw coal with different heating value.

Introduction: Coal represents a significant natural resource in our world, and its quality and commercial value is primarily determined by its heating capacity. Numerous scientists worldwide have attempted to explore the impact of various environmental factors on coal rank, yet their conclusions are often inconsistent.

Methods: In this study, the Illumina MiSeq sequencing approach was used to analyze the bacterial community from a low-rank coal mine as well as a high-rank mine.

Outcomes of Patients with Critical Limb Ischemia and Chronic Kidney Disease: A National Perspective.

Introduction: Studies exploring the relationship between peripheral arterial disease (PAD), critical limb ischemia (CLI), and chronic kidney disease (CKD) and its effect on in-hospital outcomes are limited. We aimed to analyze the outcomes of patients with CKD and PAD who are admitted for CLI.

Methods: We utilized the National Inpatient Sample (NIS) to capture hospitalizations for CLI from 2012 to 2020 and then identified cases with concomitant CKD.

Thermal-Mechanical Coupling Performance of Heat-Resistant, High-Strength and Printable Al-Si Alloy Antisymmetric Lattice Structure.

The unsatisfactory mechanical performance at high temperatures limits the broad application of 3D-printed aluminum alloy structures in extreme environments. This study investigates the mechanical behavior of 4 different lattice cell structures in high-temperature environments using AlSi12Fe2.5Ni3Mn4, a newly developed, heat-resistant, high-strength, and printable alloy.

Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor.

Background/aim: Autophagy and immunity play important roles in the growth of malignant tumors and are promising targets for tumor therapy. This study was conducted to identify differentially expressed immune genes related to autophagy in Wilms' tumor (WT) and analyze their correlation with the disease prognosis.

Materials And Methods: The public data of WT and normal kidney tissues were downloaded from TCGA, ImmPort, and GeneCards databases to obtain differentially expressed immune genes associated with autophagy.

Efficacy of corticosteroids in patients with acute respiratory distress syndrome: a meta-analysis.

Background: Acute respiratory distress syndrome (ARDS), are respiratory diseases with high morbidity and mortality. Clinical trials investigating the efficacy of corticosteroids in the treatment of ARDS often yield contradictory results. We hereby conducted a systematic review and meta-analysis to investigate the efficacy of corticosteroids in ARDS management.

AI-based derivation of atrial fibrillation phenotypes in the general and critical care populations.

Background: Atrial fibrillation (AF) is the most common heart arrhythmia worldwide and is linked to a higher risk of mortality and morbidity. To predict AF and AF-related complications, clinical risk scores are commonly employed, but their predictive accuracy is generally limited, given the inherent complexity and heterogeneity of patients with AF. By classifying different presentations of AF into coherent and manageable clinical phenotypes, the development of tailored prevention and treatment strategies can be facilitated.

Construction of carbon quantum dots/riboflavin fluorescent probe and its application in the detection of ciprofloxacin.

The research outlined a novel approach for creating a sensitive and efficient ratio fluorescent probe for ciprofloxacin (CIP) detection. The method used the biomass materials passionfruit shell and diethylenetriamine as carbon and nitrogen sources, respectively, to prepare blue fluorescent carbon quantum dots (b-CQDs) with an average size of 3.29 nm and a quantum yield of 19.

Efficient Solar Steam Generation by Multiscale Photothermal Structures Derived from Cactus Stems.

Solar steam generation (SSG) is a promising technique that may find applications in seawater desalination, sewage treatment, etc. The core component for SSG devices is photothermal materials, among which biomass-derived carbon materials have been extensively attempted due to their low cost, wide availability, and diversified microstructures. However, the practical performance of these materials is not satisfactory because of the multifaceted structural requirements for photothermal materials in SSG scenarios.

Guidance of development, validation, and evaluation of algorithms for populating health status in observational studies of routinely collected data (DEVELOP-RCD).

Background: In recent years, there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data (RCD). These studies rely on algorithms to identify specific health conditions (e.g.

The Methodological Quality of Observational Studies Examining the Risk of Pregnancy Drug Use on Congenital Malformations Needs Substantial Improvement: A Cross-Sectional Survey.

Background And Objective: An increasing number of observational studies have investigated the risk of using drugs during pregnancy on congenital malformations. However, the credibility of the causal relationships drawn from these studies remains uncertain. This study aims to evaluate the potential methodological issues in existing observational studies.

[Authenticity discrimination for Galli Gigerii Endothelium Corneum based on UPLC-MS/MS and peptidomics].

Peptidomics was employed to systematically analyze the characteristic peptides in Galli Gigerii Endothelium Corneum and its adulterants and establish a method for distinguishing Galli Gigerii Endothelium Corneum from its adulterants, including the gizzard membranes from ducks, geese, and pigeons. UPLC-Q-Exactive Orbitrap-MS was combined with multivariate statistical analysis to analyze the peptides in Galli Gigerii Endothelium Corneum and its adulterants. The structures of peptides were identified by pNovo combined with manual recognition of spectra, and synthetic peptide standards were used for validation.

Synthesis of InAl-alloyed GaO nanowires for self-powered ultraviolet detectors by a CVD method.

GaO is a kind of wide-band gap semiconductor, which has great potential in deep ultraviolet detection because of its high efficiency and fast response. Doping can improve the photoelectric properties of GaO materials. In this paper, In and Al elements alloyed GaO nanowires (InAl-GaO NWs) were successfully grown on p-GaN using a cost-effective chemical vapor deposition method and a vertical structure.

Enrollment of Black, Indigenous and People of Color (BIPOC) and female participants in the US diabetes trials spanning 2000 to 2020: A chronological survey.

Aims: Little is known about the enrollment practice of both Black, Indigenous and People of Color (BIPOC) and females in the US diabetes trials. We aimed to perform a chronological survey to evaluate the enrollment of BIPOC and female participants in the US diabetes randomized controlled trials (RCTs) over the past two decades.

Methods: We searched databases to systematically include the US diabetes RCTs from 2000 January 1st to 2020 December 31st.

Effect of Acupuncture for Methadone Reduction : A Randomized Clinical Trial.

Background: Methadone maintenance treatment (MMT) is effective for managing opioid use disorder, but adverse effects mean that optimal therapy occurs with the lowest dose that controls opioid craving.

Objective: To assess the efficacy of acupuncture versus sham acupuncture on methadone dose reduction.

Design: Multicenter, 2-group, randomized, sham-controlled trial.