Publications by authors named "GuoSong Shang"
Deep brain stimulation of the nucleus basalis of Meynert in severe Alzheimer's disease.
J Alzheimers Dis Rep
November 2024
Background: Alzheimer's disease (AD) is increasingly prevalent, leading to severe cognitive decline and a diminished quality of life for patients. Nucleus basalis of Meynert deep brain stimulation (NBM-DBS) is a potential treatment approach.
Objective: This study aims to assess the efficacy and safety of NBM-DBS for AD patients.
Background: Severe Alzheimer's disease (AD) is characterized by significant neuropsychiatric symptoms and sleep disorders, with limited effectiveness of conservative drug treatments. Deep brain stimulation (DBS) offers a potential alternative.
Objective: To evaluate the efficacy, safety, and long-term outcomes of DBS versus conservative treatment in patients with severe AD.
Multi-scale Analysis Reveals Hippocampal Subfield Vulnerabilities to Chronic Cortisol Overexposure: Evidence from Cushing's Disease.
Biol Psychiatry Cogn Neurosci Neuroimaging
January 2025
Background: Chronic cortisol overexposure plays a significant role in the development of neuropathological changes associated with neuropsychiatric and neurodegenerative disorders. The hippocampus, the primary target of cortisol, may exhibit characteristic regional responses due to its internal heterogeneity. This study explores structural and functional alterations of hippocampal subfields in Cushing's disease (CD), an endogenous model of chronic cortisol overexposure.
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- The study aims to compare the effectiveness and safety of deep brain stimulation (DBS) and vagus nerve stimulation (VNS) in improving motor function for patients with poststroke hemiplegia, as no prior comparison exists.
- It is a randomized, double-blind clinical trial involving 64 patients at least six months post-stroke, assessing outcomes like motor function, safety, and quality of life over various follow-up periods.
- Patients will be divided into Stimulation and Sham Groups to alternate treatments, monitoring both immediate and long-term effects of stimulation therapies on recovery and functionality.
Article Synopsis
- * This study used advanced imaging techniques to analyze the functional connectivity of the brain in 86 CD patients compared to 54 healthy controls, revealing significant alterations in brain networks linked to cognitive processes.
- * The research found that changes in specific brain regions associated with sensory and cognitive functions correlated with cortisol levels and gene expression related to synaptic function, indicating that hypercortisolism may influence cognitive impairments through these neural and genetic changes.
Various techniques have been used for management of congenital atlantoaxial dislocation. Recently, the reduction of atlantoaxial dislocation through a single posterior approach has attracted more and more attention. Here, we present a modified technique including direct interfacet release and distraction between C1 and C2 by a specially designed distractor, posterior internal fixation and bone graft fusion.
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