Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken.

To investigate the effect of fresh corn extract (FCE) on chicken meat quality, 135-day-old Jingyuan chicken hens were fed diets containing different doses of FCE (CON, 0.3% FCE, 0.6% FCE and 0.

Iron nanoparticle/carbon nanotube composite as oxidase-like nanozyme for visual analysis of total antioxidant capacity.

Total antioxidant capacity (TAC) is an important indicator for assessing the merit of natural plants and foods. Herein, a visual TAC assay is developed based on the oxidase-like activity of nitrogen-doped carbon nanotubes loaded with Fe nanoparticles (FeNPs@NCNT), which is prepared via high-temperature pyrolysis of metal-organic framework precursors and can catalyze the oxidation of colorless -phenylenediamine (OPD) to colored 2,3-diaminophenazine (DAP). The addition of antioxidants (e.

Trans-dimensional nanocoral gold foam interfaces affords ultrasensitive detection of influenza virus.

Development of sensitive and cost-effective strategies for detecting influenza viruses is crucial to combat the spread of infectious diseases. In this study, a novel trans-dimensional nanocoral gold foam (NCGF) was fabricated on screen-printed carbon electrodes using hydrogen template electrodeposition method. This unique structure, with interconnected large and small pores, significantly increased the specific surface area and stability of the sensor.

Feasibility of Lobectomy in Selected Patients with Unilateral N1b Papillary Thyroid Cancer.

Background: Total thyroidectomy (TT) is usually recommended for unilateral papillary thyroid cancer (PTC) with lateral lymph node metastasis (LLNM), but no significant improvement in recurrence-free survival (RFS) is seen upon treatment. As an initial surgery, lobectomy may have advantages in appropriately selected unilateral PTC with ipsilateral LLNM.

Objective: This study aimed to explore the feasibility of lobectomy for selected unilateral PTC with ipsilateral LLNM.

Inflammatory and Nutritional Markers as Indicators for Diagnosing and Assessing Disease Activity in MS and NMOSD.

Background: Inflammation and nutritional markers have recently gained recognition for their roles in the fabrication of cognitive control centers demyelinating illnesses. Inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), along with nutritional markers like albumin (ALB), hemoglobin (HB), and body mass index (BMI), may predict disease occurrence. However, their potential in evaluating diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) remains unexplored.

Germline Alteration Analysis Reveals EPHB4R91H Mutation as a Key Player in Multiple Primary Lung Tumors.

Multiple primary lung tumor is garnering attention from clinicians, with adenocarcinoma emerging as the predominant histological type. Because of the heterogeneity and diffuse distribution of lesions in the same patient, the treatment of multiple primary lung adenocarcinoma (MPLA) is a significant challenge. As a kind of variation unaffected by tumor heterogeneity, germline alterations may play a key role in the development of MPLA.

Toripalimab Plus Chemotherapy as a First-Line Therapy for Extensive-Stage Small Cell Lung Cancer: The Phase 3 EXTENTORCH Randomized Clinical Trial.

Importance: Patients with extensive-stage small cell lung cancer (ES-SCLC) have poor prognoses and unmet medical needs.

Objective: To evaluate the efficacy and safety of toripalimab plus etoposide and platinum-based chemotherapy (EP) vs placebo plus EP as a first-line treatment for patients with ES-SCLC.

Design, Setting, And Participants: This multicenter, double-blind, placebo-controlled phase 3 randomized clinical trial (EXTENTORCH study) enrolled patients from September 26, 2019, to May 20, 2021, and was conducted at 49 sites in China.

Tuina Promotes Repair of Chronic Cervical Muscle Injury by Regulating Satellite Cell Proliferation and Differentiation and Inhibiting Myocyte Apoptosis.

Purpose: Chronic cervical muscle injury is the first common cause of the development of cervical spondylosis, and Tuina can effectively promote the repair of chronic cervical muscle injury and alleviate neck pain, but the mechanism behind its efficacy is still unknown. The proliferation and differentiation of muscle satellite cells and the apoptosis of cervical myocytes play important roles in the repair of chronic cervical muscle injuries; therefore, this study aimed to explore the potential mechanisms of Tuina to promote the repair of cervical muscle injuries in terms of the proliferation and differentiation of satellite cells and the apoptosis of myocytes.

Patients And Methods: Twenty-eight Wistar rats were randomly divided into control group, model group, Tuina group, and meloxicam group, with 7 rats in each group.

Thermal Bending Simulation and Experimental Study of 3D Ultra-Thin Glass Components for Smartwatches.

The heating system is an essential component of the glass molding process. It is responsible for heating the glass to an appropriate temperature, allowing it to soften and be easily molded. However, the energy consumption of the heating system becomes particularly significant in large-scale production.

A PLA-mediated transistor biosensor enables specific identification of tumor-derived exosomal PD-L1.

The expression of programmed death ligand 1 (PD-L1) on tumor-derived exosomes (tExos) forecasts the efficacy of immunotherapy and tumor diagnosis. Due to the heterogeneity of exosomes, current detection methods face challenges in distinguishing between tumor-derived and non-tumor-derived exosome PD-L1. To address this challenge, we introduce a novel field effect transistor (FET) biosensor based on proximity ligation assay (PLA) technology.

Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery.

Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report a combined strategy of immuno-positron emission tomography (PET) for preoperative detection of breast cancer and guided assessment of margins in breast-conserving surgery through second near-infrared (NIR-II) fluorescence imaging of trophoblastic cell surface antigen 2 (TROP2). We demonstrated that the intensity of PET signals in the tumors was nearly five times higher than in normal breast tissue with a zirconium-89 tracer conjugated to sacituzumab govitecan (SG) in a mouse spontaneous breast cancer model, enabling the identification of tumors.

DOA Estimation Method for Vector Hydrophones Based on Sparse Bayesian Learning.

Through extensive literature review, it has been found that sparse Bayesian learning (SBL) is mainly applied to traditional scalar hydrophones and is rarely applied to vector hydrophones. This article proposes a direction of arrival (DOA) estimation method for vector hydrophones based on SBL (Vector-SBL). Firstly, vector hydrophones capture both sound pressure and particle velocity, enabling the acquisition of multidimensional sound field information.

Rapidly one-step fabrication of durable superhydrophobic graphene surface with high temperature resistance and self-clean.

High temperature resistant and self-cleaning superhydrophobic flexible film has potential application value in lunar exploration. In this paper, a novel method of magnetic field-assisted ultrafast laser induced plasma was proposed to fabricate strongly superhydrophobic graphene on polyimide film with multi-level micro-nano structure. The longitudinal magnetic field contributed to constrain the induced plasma in the lateral direction so as to form a plasma plume with high temperature and high energy density.

SULF1 expression is increased and promotes fibrosis through the TGF-β1/SMAD pathway in idiopathic pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown etiology. Despite the increasing global incidence and poor prognosis, the exact pathogenic mechanisms remain elusive. Currently, effective therapeutic targets and treatment methods for this disease are still lacking.

Corrigendum: Clinical characteristics and prognosis of patients with pulmonary mucoepidermoid carcinoma: a SEER-based analysis.

[This corrects the article DOI: 10.3389/fonc.2021.

Precision patient selection for improved detection of circulating genetically abnormal cells in pulmonary nodules.

Circulating genetically abnormal cells (CACs) have emerged as a promising biomarker for the early diagnosis of lung cancer, particularly in patients with pulmonary nodules. However, their performance may be suboptimal in certain patient populations. This study aimed to refine patient selection to improve the detection of CACs in pulmonary nodules.

Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense.

Regulatory T cells (Tregs), characterized by the expression of Forkhead Box P3 (FOXP3), constitute a distinct subset of T cells crucial for immune regulation. Tregs can exert direct and indirect control over immune homeostasis by releasing inhibitory factors or differentiating into Th-like Treg (Th-Treg), thereby actively contributing to the prevention and treatment of autoimmune diseases. The epigenetic regulation of , encompassing DNA methylation, histone modifications, and post-translational modifications, governs the development and optimal suppressive function of Tregs.

Facile Preparation of Superhydrophobic PDMS Polymer Films with Good Mechanical Strength Based on a Wear-Resistant and Reusable Template.

In this paper, a new method involving a wear-resistant and reusable template is proposed for the preparation of high-mechanical-strength superhydrophobic polymer film based on wire electrical discharge machining (WEDM). A solid-liquid-contact-angle simulation model was established to obtain surface-texture types and sizes that may achieve superhydrophobicity. The experimental results from template preparation show that there is good agreement between the simulation and experimental results for the contact angle.