Publications by authors named "GuoHui Xu"

To investigate whether blocking both programmed cell death protein and vascular endothelial growth factor receptor could offer superior anticancer activity in these patients without compromising safety. In this study, patients were administered oral anlotinib (12 mg/day) on days 1-14 and intravenous sintilimab (200 mg) on day 1 of a 3-weekly cycle. The primary endpoints included the objective response rate and disease control rate.

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  • The study investigates the impact of cancer cachexia in patients with hepatocellular carcinoma (HCC), focusing on how body composition changes over time can help identify cachexia.
  • It utilizes a cohort of unresectable HCC patients treated with specific therapies, analyzing body composition through CT scans to categorize patients into different cachexia phases based on their skeletal muscle mass and total adipose tissue.
  • Findings reveal that patients experiencing significant declines in muscle and tissue mass have worse overall survival outcomes, highlighting the importance of monitoring body composition in HCC treatment plans.
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BACKGROUND Lumbar fusion and internal fixation techniques have shown promise in treating lumbar disc herniation (LDH), yet the impact on lumbar function in young patients remains unclear. This study aimed to investigate the impact of lumbar fusion on lumbar function in young patients. MATERIAL AND METHODS A retrospective analysis was conducted on 330 patients diagnosed with LDH admitted to our hospital.

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Background: The prognostic value of tumor deposits (TDs) in stage III colorectal cancer (CRC) patients is poorly described based on the current tumor node metastasis (TNM) stage system.

Materials And Methods: Based on the data from the Surveillance, Epidemiology, and End Result (SEER) database between 2010 to 2020 and local hospital between 2006 to 2022, the clinicopathological features of stage III CRC patients with TDs were screened by Chi-square test. Kaplan-Meier curves were performed to describe the significant difference in overall survival (OS) among the different groups, and log-rank tests were used to compare the cumulative survival distributions.

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Background: Robot-Assisted Gait Training (RAGT) is a novel technology widely employed in the field of neurological rehabilitation for patients with subacute stroke. However, the effectiveness of RAGT compared to conventional gait training (CGT) in improving lower extremity function remains a topic of debate. This study aimed to investigate and compare the effects of RAGT and CGT on lower extremity movement in patients with subacute stroke.

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Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that the control western blots shown for Fig. 1A and B on p. 908 and Fig.

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  • * Researchers identified 57 relevant genes in the blueberry genome, categorizing them into three main subgroups and analyzing their evolutionary relationships and expression patterns, especially under stress conditions.
  • * The study found that certain genes were highly expressed in blueberry fruit and roots, with specific genes responding significantly to various stress factors, setting the stage for future research on improving stress tolerance in this crop.
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Vaccinium L. is an important fruit tree with nutritional, medicinal, and ornamental values. However, the mitochondrial (mt) genome of Vaccinium L.

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  • Blueberry is an economically important fruit that was domesticated in the early 1900s through hybridization, with the research including 220 accessions from multiple countries.
  • The study focused on identifying genetic traits that differentiate northern highbush blueberries (NHB) from southern highbush blueberries (SHB), revealing specific genes linked to climate adaptability and fruit quality.
  • Whole-genome sequencing and analysis indicated significant genetic variation and epigenetic differences, particularly in the β-alanine metabolic pathway, providing essential resources for future blueberry breeding efforts.
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2. This research investigates the impact of the EGCG-CSH/n-HA/CMC composite material on bone defect repair, emphasizing its influence on macrophage polarization and osteogenic differentiation of BMSCs. Comprehensive evaluations of the composite's physical and chemical characteristics were performed.

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Estuaries and coasts are located at the land-sea interface, where sediment liquefaction due to strong wave action results in significant material exchange at the sediment-seawater system. Polycyclic aromatic hydrocarbons (PAHs), as organic pollutants, are distributed across various media. Herein, the impact of wave was studied on the release of PAHs through indoor microcosmic experiments combined with a level IV fugacity model.

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Background: The survival paradox (ie, the prognosis of the population at earlier tumor stages is worse than that of the population at later stages) has been observed in colorectal cancer based on the American Joint Committee on Cancer Tumor-Nodes-Metastases staging system. We aimed to clarify the reason for the survival paradox and its impact on patient treatment.

Methods: We conducted a retrospective study analyzing eligible patients with colorectal cancer from the Surveillance, Epidemiology, and End Results database and Zhejiang Cancer Hospital between 2010 and 2019.

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  • Wuhu Oral Liquid (WHOL) is an advanced version of a traditional Chinese remedy, known for its ability to reduce inflammation and pain while speeding up recovery from soft tissue injuries.
  • A clinical trial involving 480 subjects compared WHOL to a control drug, Fufang Shang Tong Capsule (FFSTC), measuring pain relief and other symptoms over 10 days.
  • Results showed that patients using WHOL experienced significantly greater reductions in pain and improved swelling compared to those taking FFSTC, demonstrating its potential effectiveness for treating acute soft tissue injuries.
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  • Repetitive transcranial magnetic stimulation (rTMS), particularly intermittent theta-burst stimulation (iTBS), shows promise in providing neuroprotection during early cerebral ischemia/reperfusion (I/R) injuries by enhancing cortical excitability.
  • A study involving rat models revealed that iTBS significantly reduced markers of endoplasmic reticulum stress (ERS), ferroptosis, and apoptosis while also improving neurological function as measured by the modified Neurological Severity Score (mNSS) and balance tests.
  • The findings suggest that iTBS is a time-efficient and cost-effective treatment for I/R injury, potentially providing significant therapeutic benefits without sacrificing treatment efficacy.
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Purpose: To compare the efficacy and safety of transarterial chemoembolization (TACE) plus donafenib with immune checkpoint inhibitors (ICIs) (T+D+I) versus TACE plus donafenib (T+D) as the first-line treatment for patients with unresectable hepatocellular carcinoma (HCC).

Methods: This retrospective study included patients with unresectable HCC who received T+D+I or T+D between June 2021 and February 2023. The tumor response was analyzed according to the modified Response Evaluation Criteria in Solid Tumors.

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  • The study investigates the role of oncogenes in the progression of hepatocellular carcinoma (HCC), highlighting the overexpression of peroxiredoxin 2 (PRDX2) in HCC patients' bile compared to those with gallstones.
  • PRDX2 was found to enhance HCC cell viability and its silencing caused the cells to enter senescence, while knockdown also reduced tumor growth in xenograft models.
  • The research revealed that PRDX2 activates the Wnt/β-catenin signaling pathway, and inhibiting PRDX2 not only decreases HCC cell proliferation but also promotes cellular aging and dampens the Wnt/β-catenin pathway.
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  • * These areas are vulnerable to liquefaction due to their soft sediments and shallow depths, which can release buried microplastics during strong waves and wind.
  • * Laboratory experiments simulated this process, finding that 56.2% of microplastics were released back into the sediment surface during liquefaction, particularly larger particles, with maximum release rates estimated at 0.34 mm/min.
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The cell division cycle 20 homologue (CDC20) is known to regulate the cell cycle. Many studies have suggested that dysregulation of CDC20 is associated with various pathological processes in malignant solid tumors, including tumorigenesis, progression, chemoradiotherapy resistance, and poor prognosis, providing a biomarker for cancer diagnosis and prognosis. Some researchers have demonstrated that CDC20 also regulates apoptosis, immune microenvironment, and tumor angiogenesis.

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  • Researchers sought to improve the efficiency of genetic transformation in blueberries using a new leaf callus regeneration system.
  • The study used ‘Legacy’ and ‘Northland’ blueberry leaf explants and established a stable callus induction through specific plant media and growth conditions.
  • Successful transformation resulted in transgenic blueberry callus exhibiting 49.02% GFP signal detection, indicating this method can enhance molecular breeding efforts for blueberries.
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The color of a fruit is an important contributor to the perception of its nutritional value. It is widely acknowledged that the color of sweet cherry changes obviously during ripening. Variations in anthocyanins and flavonoids account for the heterogeneous color of sweet cherries.

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Accurate segmentation of liver tumors is a prerequisite for early diagnosis of liver cancer. Segmentation networks extract features continuously at the same scale, which cannot adapt to the variation of liver tumor volume in computed tomography (CT). Hence, a multi-scale feature attention network (MS-FANet) for liver tumor segmentation is proposed in this paper.

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Background: Programmed cell death ligand 1 (PD-L1) is highly expressed in intrahepatic cholangiocarcinoma (ICC) tissues. But there is still a dispute over the prognostic value of PD-L1 in patients with ICC. This study aimed to evaluate the prognostic value of PD-L1 expression in patients with ICC.

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