Combination therapy that promotes both apoptosis and immunogenic cell death (ICD) holds promise for enhanced tumor treatment, yet its effectiveness is often hindered by challenges including inadequate targeted delivery, intricate nanoformulations processes, and cost inefficiency. Here, we present novel tumor-targeted, stimuli-responsive nanomicelles (D@CGO-G) through a straightforward supramolecular self-assembly method, incorporating targeting peptide GE11, doxorubicin (DOX), and a labile carrageenan (CG) linkage. Mechanistic insights into nanomicelles assembly process are thoroughly investigated using molecular dynamics (MD) simulations.
View Article and Find Full Text PDFBackground: Paphiopedilum orchids have a high ornamental value, and flower abundance is a key horticultural trait. Most Paphiopedilum plants exhibit weak tillering ability, with their tiller buds often entering a dormant state post-formation. Tiller production plays a crucial role in enhancing flower abundance and is potentially regulated by plant hormones.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Two-dimensional (2D) Ruddlesden-Popper perovskites (RPPs) have garnered significant attention due to their enhanced stability compared with their three-dimensional counterparts. However, the power conversion efficiency (PCE) of 2D perovskite solar cells (2D-PSCs) remains lower than that of 3D-PSCs. Understanding the microstructural evolution of 2D perovskite films during fabrication is essential for improving their performance.
View Article and Find Full Text PDFSantalum album is an economically important plant in the craft, spices and medicine industries. The main chemical constituents found in sandalwood essential oils are sesquiterpenes. 3-Hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGR) is one of the rate-limiting enzymes required for the synthesis of sandal sesquiterpenes, but there are no studies on the HMGR gene in S.
View Article and Find Full Text PDFBackground: The extract from Metasequoia glyptostroboides Hu et Cheng, a rare and endangered species native to China, exhibits numerous biological and pharmacological activities. The species is recalcitrant to rooting during micropropagation, a challenge that has yet to be resolved. In this study, transcriptomic and hormonal analyses were conducted to appreciate the molecular mechanism of adventitious root (AR) formation in optimized rooting conditions.
View Article and Find Full Text PDFPhotovoltaic photodiodes often face challenges in effectively harvesting electrical signals, especially when detecting faint light. In contrast, photomultiplication type photodetectors (PM-PDs) are renowned for their exceptional sensitivity to weak signals. Here, an advanced PM-PD is introduced based on quasi 2D Ruddlesden-Popper (Q-2D RP) perovskites, optimized for weak light detection at minimal operating voltages.
View Article and Find Full Text PDFThere are typographical errors with the pictures and tables in the original text, and these should be corrected in this corrigendum. The authors state that these corrections do not affect the methods, results, or conclusions of the original text.
View Article and Find Full Text PDFObjective: When chatting, people often forget what they want to say, that is, they suffer from subjective memory complaints (SMCs). This research examines the Association between sleep duration and self-reported SMC in a sample representing the entire United States.
Methods: We examined data from 5567 individuals (aged 20-80) who participated in the National Health and Nutrition Examination Survey (2015-2018) to evaluate the association between sleep duration and SMC.
Santalum album is a well-known aromatic and medicinal plant that is highly valued for the essential oil (EO) extracted from its heartwood. In this study, we present a high-quality chromosome-level genome assembly of S. album after integrating PacBio Sequel, Illumina HiSeq paired-end and high-throughput chromosome conformation capture sequencing technologies.
View Article and Find Full Text PDFBackground: Cultivated Hippeastrum × hybridum is a popular ornamental plant with large and colorful flowers, long flowering duration, and high commercial value. As its main ornamental feature, its flower color is related to the anthocyanin content in the tepals. However, the molecular regulatory mechanisms of anthocyanin biosynthesis in H.
View Article and Find Full Text PDFSantalum album (E,E)-α-farnesene synthase catalyzes FPP into (E,E)-α-farnesene. Overexpression of the SaAFS gene positively improved cold stress tolerance through JA biosynthesis and signaling pathways in Arabidopsis. Volatile terpenoids are released from plants that suffer negative effects following exposure to various biotic and abiotic stresses.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
April 2023
Background: Betaine aldehyde dehydrogenase (BADH) catalyzes the synthesis of glycine betaine and is considered to be a type of osmoregulator, so it can play a role in plants' responses to abiotic stresses.
Methods: In this study, a novel gene from (pitaya) was cloned, identified, and sequenced. The full-length cDNA included a 1512 bp open reading frame that encoded a 54.
Background: Aglaonema commutatum 'Red Valentine', as a foliage ornamental plant, is widely used for interior and exterior decoration because of its easy cultivation and management. However, reduced proportion of red foliage during large-scale production of A. commutatum seedlings is a frequent occurrence, which has considerable implications on the plant's ornamental and market value.
View Article and Find Full Text PDFExtraction optimization is very important for the quality of humic acid (HA). In this study, actived HA (HA) was extracted from danty via catalytic oxidation using birnessite as a catalyst and HO as an oxidant. Single-factor experiments and the response surface method were used to optimize the acidic functional group content of HA.
View Article and Find Full Text PDFEuryodendron excelsum H.T. Chang is a rare and endangered woody plant endemic to China.
View Article and Find Full Text PDFSandalwood (Santalum album L.) is a hemi-parasitic tree species famous for its santalol and santalene, which are extracted from its heartwood and roots. The ability to understand root functionality within its branched root system would benefit the regulation of sandalwood growth and enhance the commercial value of sandalwood.
View Article and Find Full Text PDFThe commercial value of Santalum album L. lies in its aromatic heartwood and essential oil. Sesquiterpenes are the main components of sandal essential oil, and these are synthesized through the plant's mevalonate (MVA) and methylerythritol phosphate (MEP) pathways.
View Article and Find Full Text PDFis one of the most popular foliage plants with abundant leaf phenotypes; therefore, anthocyanin coloration is a vital economic trait in . However, the molecular mechanisms underlying anthocyanin biosynthesis and its regulation remain unclear. In this study, and , transcription factor genes related to an R2R3-myeloblast (MYB) and a basic helix-loop-helix (bHLH), respectively, were isolated from "Red Valentine" and functionally characterized.
View Article and Find Full Text PDFL., a semi-parasitic evergreen tree, contains economically important essential oil, rich in sesquiterpenoids, such as () α- and () β-santalol. However, their transcriptional regulations are not clear.
View Article and Find Full Text PDFCoated diammonium phosphate (CDAP) is intended to release nutrients steadily in response to the demand of crop growth. A novel biostimulant extracted from has been shown to regulate gene expression in nutrient transport, enhance nitrogen (N) and phosphorus (P) uptake, and improve nutrient use efficiency. The application of CDAP combined with the extracts (ZNC) in maize is an efficient approach for reducing waste of resources, improving nutrient supply, and maintaining production stability.
View Article and Find Full Text PDForchids have a high ornamental value, and their flower abundance and timing are both key horticultural traits regulated by phytohormones. All one-flowered have additional lateral buds in the apical bract that fail to develop. In this study, an exogenous gibberellin (GA) application promoted flowering of by inducing its early bolting instead of the floral transition of dominant flowers.
View Article and Find Full Text PDFControlled release phosphorus (P) fertilizers and humic acid (HA) applications are two effective and significant techniques or measures for preventing P loss and enhancing maize development. However, the underlying physiological mechanism of how the controlled release P fertilizers combined with HA affect the maize production and P-use efficiency (PUE) remains unknown. The effects of applying coated diammonium phosphate (CDAP) and HA together on soil nutrient supply intensity, soil phosphatase activity, photosynthesis, endogenous hormone contents, and yield of maize, as well as PUE, were examined in this study.
View Article and Find Full Text PDFNAC (NAM, ATAF1/2, and CUC2) proteins play a pivotal role in modulating plant development and offer protection against biotic and abiotic stresses. Until now, no systematic knowledge of NAC family genes is available for the food security crop, sweet potato. Here, a comprehensive genome-wide survey of NAC domain-containing proteins identified 130 and 144 genes with full length sequences in the genomes of two diploid wild relatives of cultivated sweet potato, and , respectively.
View Article and Find Full Text PDFBackground: Paphiopedilum, commonly known as slipper orchid, is an important genus of orchid family with prominent horticultural value. Compared with conventional methods such as tillers and in vitro shoots multiplication, induction and regeneration of protocorm-like bodies (PLBs) is an effective micropropagation method in Paphiopedilum. The PLB initiation efficiency varies among species, hybrids and varieties, which leads to only a few Paphiopedilum species can be large-scale propagated through PLBs.
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