Performance and mechanisms of nitrogen removal from low-carbon source wastewater in an iron-carbon coupled biofilm airlift internal circulation sequencing batch reactor.

An iron-carbon coupled biofilm airlift internal circulation sequencing batch reactor (IC-SBR) was constructed to treat low-carbon source wastewater. Single-factor experiments were used to determine the optimal operating conditions for the IC-SBR, with a hydraulic retention time (HRT) of 10 h, a dissolved oxygen (DO) concentration of 3 mg/L, a C/N ratio of 3, and an influent NH-N concentration of 50 mg/L, with average removal efficiencies of total nitrogen (TN) and total organic carbon (TOC) of 78.06% and 97.

HER2 becomes a novel survival biomarker for gastric cancer patients: a pooled analysis.

Background: Although anti-HER2 therapies have been widely used against gastric carcinoma, the prognostic significance of HER2 overexpression remains unclear. Previous studies failed to provide convincible evidence due to inconsistent HER2 evaluation criteria and heterogeneous clinical characteristics.

Objectives: To figure out the prognostic significance of HER2 expression in gastric cancer, we rigorously designed and conducted this study.

Outcome of intravenous and inhaled polymyxin B treatment in patients with multidrug-resistant gram-negative bacterial pneumonia.

Purpose: The incidence of pneumonia caused by multidrug-resistant gram-negative bacteria (MDR GNB) is increasing, which imposes significant burden on public health. Inhalation combined with intravenous polymyxins has emerged as a viable treatment option. However, pharmacokinetic studies focusing on intravenous and inhaled polymyxin B (PMB) are limited.

Unraveling the effects and mechanisms of antibiotics on aerobic simultaneous nitrogen and phosphorus removal by Acinetobacter indicus CZH-5.

The effects of antibiotics, such as tetracycline, sulfamethoxazole, and ciprofloxacin, on functional microorganisms are of significant concern in wastewater treatment. This study observed that Acinetobacter indicus CZH-5 has a limited capacity to remove nitrogen and phosphorus using antibiotics (5 mg/L) as the sole carbon source. When sodium acetate was supplied (carbon/nitrogen ratio = 7), the average removal efficiencies of ammonia-N, total nitrogen, and orthophosphate-P increased to 52.

Integrated analysis of colorectal cancer metastasis identifies characteristics of tumor cell during metastasis.

Background: Metastasis is the main cause of death in colorectal cancer (CRC). Metastasis is a sequential and dynamic process, but the development of tumor cells during this process is unclear. In this study, we aimed to reveal characteristics of tumor cell subset during CRC metastasis.

Sensitive and rapid identification of pathogens by droplet digital PCR in a cohort of septic patients: a prospective diagnostic study.

Background: There is a critical need for a rapid and sensitive pathogen detection method for septic patients. This study aimed to investigate the diagnostic efficacy of Digital droplet polymerase chain reaction (ddPCR) in identifying pathogens among suspected septic patients.

Methods: We conducted a prospective pilot diagnostic study to clinically validate the multiplex ddPCR panel in diagnosing suspected septic patients.

Evaluating spray drift from Uncrewed Aerial Spray Systems: A machine learning and variance-based sensitivity analysis of environmental and spray system parameters.

Uncrewed Aerial Spray Systems (UASS), commonly called drones, have become an important application technique for plant protection products in Asia and worldwide. As such, environmental variables and spray system parameters influencing spray drift deserve detailed investigations. This study presents the data analysis of 114 UASS drift trials conducted between December 2021 and December 2022 in China.

Assessing the efficiency of UAV for pesticide application in disease management of peanut crop.

Background: Effective utilization of plant protection UAVs in peanut cultivation management necessitates a comprehensive grasp of how application volume rates and pesticides influence peanut leaf spot and rust control. This study aimed to compare the effects of application volume rates and pesticides on droplet deposition, disease, leaf retention rate and peanut yield. A T20 plant protection unmanned aerial vehicle (UAV) sprayer was used to apply four various pesticide doses.

Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.

Colorectal cancer (CRC) is a major cause of cancer mortality and a serious health problem worldwide. Mononuclear phagocytes are the main immune cells in the tumor microenvironment of CRC with remarkable plasticity, and current studies show that macrophages are closely related to tumor progression, invasion and dissemination. To understand the immunological function of mononuclear phagocytes comprehensively and deeply, we use single-cell RNA sequencing and classify mononuclear phagocytes in CRC into 6 different subsets, and characterize the heterogeneity of each subset.

Identification of a lipid homeostasis-related gene signature for predicting prognosis, immunity, and chemotherapeutic effect in patients with gastric cancer.

Gastric cancer (GC) is one of the most common and deadliest cancers worldwide. Lipid homeostasis is essential for tumour development because lipid metabolism is one of the most important metabolic reprogramming pathways within tumours. Elucidating the mechanism of lipid homeostasis in GC might significantly improve treatment strategies and patient prognosis.

Zinc-oxide nanoparticles ameliorated the phytotoxic hazards of cadmium toxicity in maize plants by regulating primary metabolites and antioxidants activity.

Cadmium stress is a major threat to plant growth and survival worldwide. The current study aims to green synthesis, characterization, and application of zinc-oxide nanoparticles to alleviate cadmium stress in maize ( L.) plants.

Tryptophan Seed Treatment Improves Morphological, Biochemical, and Photosynthetic Attributes of the Sunflower under Cadmium Stress.

Tryptophan, as a signal molecule, mediates many biotic and environmental stress-induced physiological responses in plants. Therefore, an experiment was conducted to evaluate the effect of tryptophan seed treatment in response to cadmium stress (0, 0.15, and 0.

Genomics and metabolic characteristics of simultaneous heterotrophic nitrification aerobic denitrification and aerobic phosphorus removal by Acinetobacter indicus CZH-5.

This study provides for the first time a systematic understanding of Acinetobacter indicus CZH-5 performance, metabolic pathway and genomic characteristics for aerobic nitrogen (N) and phosphorus (P) removal. Acinetobacter indicus CZH-5 showed promising performance in heterotrophic nitrification aerobic denitrification and aerobic phosphorus removal. Under optimal conditions, the maximum ammonia-N, total nitrogen and orthophosphate-P removal efficiencies were 90.

Evaluation of the deposition and distribution of spray droplets in citrus orchards by plant protection drones.

Plant protection drone spraying technology is widely used to prevent and control crop diseases and pests due to its advantages of being unaffected by crop growth patterns and terrain restrictions, high operational efficiency, and low labor requirements. The operational parameters of plant protection drones significantly impact the distribution of spray droplets, thereby affecting pesticide utilization. In this study, a field experiment was conducted to determine the working modes of two representative plant protection drones and an electric backpack sprayer as a control to explore the characteristics of droplet deposition with different spray volumes in the citrus canopy.

Construction and validation of a immune-related prognostic gene DHRS1 in hepatocellular carcinoma based on bioinformatic analysis.

A member of the short-chain dehydrogenase/reductase superfamily (DHRS1, SDR19C1) is a member of the short-chain dehydrogenase/reductase superfamily and a potential predictor of hepatocellular carcinoma (HCC). However, the role of DHRS1 in HCC immunity remains unclear. We systematically analyzed the association between DHRS1 and HCC immunity with transcriptional and clinical data from the Tumor Immune Estimation Resource, an integrated repository portal for tumor immune system interactions, and cBioPortal databases.

Numerical Modeling of Transient Flow Characteristics on the Top Surface of a Steel Slab Continuous Casting Strand Using a Large Eddy Simulation Combined with Volume of Fluid Model.

In the current study, the transient flow characteristics on the top surface of a steel slab continuous casting strand were numerically investigated using a large eddy simulation combined with volume of fluid (LES + VOF) model. The validation of numerical simulation was verified via nail board measurement in the industrial continuous casting mold. The effects of casting speed on the top surface level profile and the instantaneous distribution of vortex were discussed.

High-sensitive and rapid electrochemical detection of miRNA-31 in saliva using Cas12a-based 3D nano-harvester with improved trans-cleavage efficiency.

Salivary miRNA-31 is a reliable diagnostic marker for early-stage oral squamous cell carcinoma (OSCC), but accurate detection of miRNA-31 in saliva samples is a challenge because of its low level and high sequence homology. The CRISPR/Cas12a system has the exceptional potential to enable simple nucleic acid analysis but suffers from low speed and sensitivity. To achieve rapid and high-sensitive detection of miRNA-31 using the CRISPR/Cas12a system, a Cas12a-based nano-harvester activated by a polymerase-driven DNA walker, named as dual 3D nanorobots, was developed.

Effect of abnormal values of three temperature indicators on ischemic stroke hospital admissions in Guangzhou, China.

Abnormal temperature has important effects on the occurrence of ischemic stroke (IS). However, relatively less efforts have been taken to systematically unravel the association between various abnormal temperature and IS hospital admission. Focusing on three temperature indicators (i.

Degradation of sulfamethoxazole by super-hydrophilic MoS sponge co-catalytic Fenton: Enhancing Fe/Fe cycle and mass transfer.

To promote the cycle of Fe/Fe in co-catalytic Fenton and enhance mass transfer in an external circulation sequencing batch packed bed reactor (ECSPBR), super-hydrophilicity MoS sponge (TMS) modified by tungstosilicic acid (TA) was prepared for efficiently degrading sulfamethoxazole (SMX) antibiotics in aqueous solution. The influence of hydrophilicity of co-catalyst on co-catalytic Fenton and the advantages of ECSPBR were systematically studied through comparative research methods. The results showed that the super hydrophilicity increased the contact between Fe and Fe with TMS, then accelerated Fe/Fe cycle.

High-efficient degradation of chloroquine phosphate by oxygen doping MoS co-catalytic Fenton reaction.

To degrade the antiviral and antimalarial drug chloroquine phosphate (CQP), an oxygen doping MoS nanoflower (O-MoS-230) co-catalyst was prepared by a hydrothermal method to construct an O-MoS-230 co-catalytic Fenton system (O-MoS-230/Fenton) without pH adjustment (initial pH 5.4). Remarkable CQP degradation efficiency (99.