Publications by authors named "Guo-yi Zhang"
Background: To evaluate the efficacy of local-regional radiotherapy (LRRT) in de novo metastatic nasopharyngeal carcinoma (dm NPC) patients receiving chemo-immunotherapy as first-line treatment and select the beneficiaries from LRRT.
Methods And Materials: M1-NPC patients receiving platinum-based chemo-immunotherapy with or without LRRT from four centers were included in this study. The propensity score matching (PSM) analysis was employed to balance the baseline characteristics between the LRRT and non-LRRT groups.
Article Synopsis
- This study focuses on improving the management of patients with de novo metastatic nasopharyngeal carcinoma (NPC) undergoing palliative immuno-chemotherapy (PICT) by predicting individual survival outcomes.
- A nomogram was developed to predict overall survival based on data from 592 patients, identifying key prognostic factors like bone metastasis and the number of metastatic lesions.
- The results indicated that patients with different M1 classifications (M1a vs. M1b) had significantly different survival rates, highlighting the nomogram's clinical usefulness in guiding treatment decisions.*
Public Awareness of Blindness Caused by Hyaluronic Acid Injection in China: A Questionnaire Survey.
Plast Reconstr Surg Glob Open
October 2024
Article Synopsis
- - The study aimed to assess public awareness regarding the risk of blindness associated with hyaluronic acid facial injections, a serious safety concern.
- - A survey of 1000 people revealed that 68.3% knew about the blindness risk, largely due to information from health blogs, social media, and news sources, with 93.4% believing that doctors should warn patients about it.
- - Most respondents had some awareness of the risk, highlighting the importance of effective communication and education on this issue before facial filler procedures.
Article Synopsis
- The study focused on creating a prognostic model using MRI radiomics features to predict the risk of distant metastasis in nasopharyngeal carcinoma (NPC) patients.
- Researchers analyzed various MRI scans and compared the performance of radiomics models, clinical models, and merged models using a cohort of 518 patients.
- Results showed that the combined T1+T1C radiomics model outperformed both the clinical and other radiomics models in predicting distant metastasis-free survival (DMFS) in a validation group of 260 NPC patients.
Background: The purpose of this study was to explore the prognostic value of imaging features and related models in nasopharyngeal carcinoma (NPC) patients that received neoadjuvant chemotherapy.
Materials And Methods: We systematically reviewed the data of 110 NPC patients who received radiotherapy and neoadjuvant chemotherapy. The patients were randomly divided into the training cohort (n = 88) and the verification cohort (n = 22).
Purpose: To explore the DSA classification and treatment strategy of tongue venous malformation.
Methods: From February 2016 to February 2019, the DSA manifestations of 132 cases with venous malformations of the tongue were summarized. They were classified into 4 types according to imaging characteristics: typeⅠ(non-drainage type), typeⅡ(lower- drainage type), type Ⅲ (higher-drainage type), type Ⅳ(extensive type).
Article Synopsis
- * As current density increases, many-body effects such as carrier scattering, bandgap renormalization, and Coulomb enhancement significantly influence the electroluminescence properties of micro-LEDs.
- * Unlike the typical "efficiency droop" seen in other light sources, higher carrier attraction in micro-LEDs leads to an unexpected increase in external quantum efficiency at very high current densities.
Background: Results regarding immediate prosthetic breast reconstruction after postmastectomy radiation therapy (PMRT) have been inconsistent.
Objectives: The authors aimed to assess the efficacy and safety of PMRT before immediate prosthetic breast reconstruction for patients with breast cancer.
Methods: Electronic databases (PubMed, EmBase, and the Cochrane Library) were systematically searched to identify eligible studies from their inception until March 2020.
Article Synopsis
- The article was originally published on March 14, 2019.
- It contained an error that needed to be addressed.
- A correction or revised version may be necessary to clarify the mistake.
Objectives: To explore and evaluate the feasibility of radiomics in stratifying nasopharyngeal carcinoma (NPC) into distinct survival subgroups through multi-modalities MRI.
Methods: A total of 658 patients (training cohort: 424; validation cohort: 234) with non-metastatic NPC were enrolled in the retrospective analysis. Each slice was considered as a sample and 4863 radiomics features on the tumor region were extracted from T1-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI.
Article Synopsis
- Researchers investigated T-cell immune responses in nasopharyngeal carcinoma (NPC) patients to improve immunotherapy treatments, focusing on T-cell distribution and characteristics.
- They found that tumors had lower TCR repertoire diversity compared to adjacent normal tissues, which was linked to poorer prognosis, while a higher diversity in peripheral blood was also associated with worse outcomes.
- The study identified specific TCR clonotypes shared between tumors and peripheral blood that could be targeted in future adoptive immunotherapy approaches for NPC patients.
Background: Bright light therapy (BLT) is an effective treatment for seasonal affective disorder and non- seasonal depression. The efficacy of BLT in treating patients with bipolar disorder is still unknown.
Aims: The aim of this study is to examine the efficacy, onset time and clinical safety of BLT in treating patients with acute bipolar depression as an adjunctive therapy (trial registration at ClinicalTrials.
Objective: This study aimed to gain information on the antimicrobial susceptibility and molecular epidemiological typing of Neisseria gonorrhoeae (NG) isolates in China in 2012.
Methods: A total of 244 NG isolates were consecutively recovered from patients with uncomplicated gonorrhea attending sexually transmitted disease clinics in 3 Chinese cities-Guangzhou, Nanjing, and Tianjin-in 2012. Neisseria gonorrhoeae susceptibilities to penicillin and tetracycline were examined by detecting penicillinase-producing NG (PPNG) and high-level tetracycline-resistant NG, and NG susceptibilities to ciprofloxacin, spectinomycin, ceftriaxone, and cefixime were determined using an agar dilution method.
Background: Potential clinical application values of certain cytokines and chemokines that participate in the process of tumor growth, invasion, and metastasis have been reported. However, there still lack of biomarkers for a great many of malignancy. This study identified cytokines or chemokines involved in the occurrence and development of nasopharyngeal carcinoma (NPC), which might be a biomarker for noninvasive early diagnosis.
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- A study was conducted to enhance the prediction accuracy of lateral retropharyngeal lymph nodes in nasopharyngeal carcinoma using MRI and PET-CT data by exploring additional nodal parameters beyond the minimal axial diameter (MIAD).
- Researchers analyzed 663 lymph nodes from 335 patients, establishing optimal cutoff values for MIAD, maximal axial diameter (MAAD), maximal coronal diameter (MACD), and the mean standard uptake value (NSUVmean) through a neural network evaluation.
- Findings indicated that an MIAD of ≥ 6.1 mm is a reliable indicator of positive nodes, while additional parameters can refine diagnoses for those below this threshold, improving prediction accuracy by reducing incorrect identifications.
Article Synopsis
- The study investigates how diffusion-weighted MRI using apparent diffusion coefficient (ADC) can predict responses to neoadjuvant chemotherapy in patients with nasopharyngeal carcinoma (NPC).
- A retrospective analysis of 92 NPC patients showed that lower pretreatment ADC values were associated with better responses to chemotherapy, with statistically significant findings for both primary lesions and metastatic sites.
- The research suggests that ADC measurements could serve as a valuable imaging biomarker to evaluate chemotherapy effectiveness in NPC patients before treatment starts.
A novel missense mutation in ADAR1 gene causing dyschromatosis symmetrica hereditaria in a Chinese patient.
Indian J Dermatol Venereol Leprol
February 2016
Article Synopsis
- This study aims to subclassify parapharyngeal extension in nasopharyngeal carcinoma (NPC) and evaluate its effects on patient prognosis using MRI data.
- The researchers analyzed 1504 NPC patients treated with radiation therapy and found that 73.4% had parapharyngeal extension, with varying involvement across anatomical sites.
- Results indicate that extensive parapharyngeal extension correlates with poorer overall survival, local relapse-free survival, and distant metastasis-free survival, suggesting it should be classified as T4 disease, while mild extension is akin to T2 disease.
Article Synopsis
- A meta-analysis was conducted to explore the link between the MTHFR 677C>T gene polymorphism and cardiovascular disease (CVD) risk in patients with end-stage renal disease (ESRD).
- The analysis included 2,292 ESRD patients from eight cohort studies, revealing that the MTHFR polymorphism may significantly increase CVD risk, particularly in Asian patients, with specific odds ratios indicating a strong correlation.
- The study concludes that individuals with the MTHFR 677C>T polymorphism, especially of Asian descent, may have a heightened risk for cardiovascular issues in the context of ESRD.
Purpose: To derive a suitable method for grading masticator space invasion in nasopharyngeal carcinoma on the basis of magnetic resonance (MR) images and to determine its prognostic value in patients undergoing intensity-modulated radiation therapy.
Materials And Methods: After institutional review board approval and informed consent were acquired, 808 patients with nasopharyngeal carcinoma who were treated with definitive intensity-modulated radiation therapy were analyzed retrospectively. The anatomic sites of masticator space involvement were identified with MR imaging.
Article Synopsis
- A study in Shenzhen, China, aimed to determine the prevalence of Mycoplasma genitalium (MG) among men who have sex with men (MSM) and identify associated risk factors.
- The research involved 409 MSM from January to May 2010, using questionnaires and urine/rectal samples for testing, resulting in an overall MG prevalence of 8.1%.
- Findings indicated that MG infection was linked to higher rates of heterosexual behaviors and unprotected anal intercourse, with rectal MG infections also associated with HIV infection.
Article Synopsis
- * A study analyzing data from 1984 to 2012 found that the global susceptibility rate of NG to cefixime is 99.8%, but it varies significantly by patient gender, geographic location, and has declined over time, particularly after 2003.
- * The susceptibility rate to cefpodoxime is lower at 92.8%, highlighting the need for better control measures against NG infections due to rising treatment
[Comparison of ultraviolet A and ultraviolet B on 1,25-dihydroxy-vitamin D3 and bone metabolism in ovariectomized rats].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2013
Objective: To investigate the effects of ultraviolet A (UVA) and ultraviolet B (UVB) on serum 1,25-dihydroxy-vitamin D3 and bone metabolism of ovariectomized rats and to compare them on bone metabolism.
Methods: In the study, 40 six-month female Sprague-Dawley rats were randomly divided into sham-operated control group (sham), osteoporosis model group (OVX), UVA irradiation group (OVX+UVA) and UVB irradiation group (OVX+UVB). Except the sham-operated control group, the remaining rats were ovariectomized to establish the osteoporosis models.
Article Synopsis
- - The study investigates skull base invasion patterns in nasopharyngeal carcinoma (NPC) using MRI, analyzing how this affects tumor staging and patient prognosis through a 5-year follow-up of 838 patients.
- - Skull base invasion was classified into high, medium, and low groups, with significant differences found in tumor staging, survival rates, and overall quality of life among these groups, particularly in overall survival rates.
- - The findings suggest that patients with medium and low skull base invasion should be classified together in the T4 category of TNM staging, potentially influencing treatment decisions.