The application of human-derived cell lines in neurotoxicity studies of environmental pollutants.

As industrial and societal advancements progress, an increasing number of environmental pollutants linked to human existence have been substantiated to elicit neurotoxicity and developmental neural toxicity. For research in this field, human-derived neural cell lines have become excellent in vitro models. This study examines the utilization of immortalized cell lines, specifically the SH-SY5Y human neuroblastoma cell line, and neural cells derived from human pluripotent stem cells, in the investigation of neurotoxicity and developmental neural toxicity caused by environmental pollutants.

[The study on supercontinuum generation of femtosecond pulse propagating in fused silica].

Starting from Nonlinear Schrodinger's equation and using the split-step Fourier method, the authors studied the characters of the supercontinuum generation of femtosecond laser pulse propagating in fused silica, and many physical factors were included such as propagation distance, input pulse peak power, diffraction effect, dispersion effect andnonlinear effect etc. The results show that when the femtosecond pulse propagated inside the fused silica, the process of supercontinuum generation could be divided into two main stages: the pulse compression stage, which was induced by the self-focus and other third nonlinear effects of the fused silica; and the pulse split stage, which was caused by the self-phase modulation and the group velocity dispersion of the fused silica. When the femtosecond pulse propagated inside the fused silica with high input peak power, the 3rd-order nonlinear effect of material induced pulse compression and then the subpulses were produced, so that new frequency components were introduced.