Publications by authors named "Guo-ping Niu"
Interferon-alpha (IFN-α) is widely used in the clinical treatment of patients with chronic hepatitis B and hepatocellular carcinoma (HCC). However, high levels of CXCL8 are associated with resistance to IFN-α therapy and poorer prognosis in advanced cancers. In this study, we investigated whether IFN-α could directly induce the production of CXCL8 in HCC cells and whether CXCL8 could antagonize the antitumor activity of IFN-α.
View Article and Find Full Text PDFBackground: Inflammatory factors are being recognized as critical modulators of host antitumor immunity in liver cancer. We have previously shown that tumor cell-released LC3B positive extracellular vesicles (LC3B EVs) are responsible for malignant progression by dampening antitumor immunity. However, the relationship between LC3B EVs and inflammatory factors in the regulation of the liver cancer microenvironment remains unclear.
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- Circulating extracellular vesicles (EVs), particularly autophagosomes expressing the LC3B marker, are being studied as potential cancer biomarkers, especially in liver cancer cases.
- Researchers analyzed plasma and ascites samples from liver cancer patients, comparing them to non-malignant liver conditions and healthy controls, using various scientific techniques to isolate and characterize these EVs.
- The study found that liver cancer patients had significantly higher levels of LC3B EVs, which could effectively differentiate them from non-cancer individuals, and those levels decreased after surgical intervention, indicating their potential role in monitoring disease progression or treatment response.
Article Synopsis
- Aconiti Sinomontani Radix is commonly used in traditional Chinese medicine for treating Bi syndrome and has shown potential therapeutic effects for rheumatoid arthritis, but its cellular mechanisms are not fully understood.
- The study investigated the effects of alkaloid extracts on the proliferation and migration of SW982 human synovial sarcoma cells using methods like MTT assays, wound scratch assays, quantitative real-time PCR, and Western blotting.
- Findings revealed that the extract significantly inhibited cell proliferation and migration in a dose-dependent manner, likely through the suppression of specific signaling pathways (Wnt5a-mediated JNK and NF-κB), suggesting its potential as a treatment for rheumatoid arthritis.
The impregnation method was used to support molecular sieve with active manganese and cerium components to obtain a composite molecular sieve catalyst. The mercury removal performance of the catalyst was studied with a bench-scale setup. XPS analysis was used to characterize the sample before and after the modification in order to study the changes in the active components of the catalyst prepared.
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