Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer.

Shenling Baizhu additive powder (SLBZ-AP), a formulation of a variety of natural medicinal plants, has clinical efficacy in treating cancers in previous studies. We explored the effect of SLBZ-AP in bone metastasis of lung cancer (BMLC) mice, and the possible mechanism involved was further investigated in the present study. Mice model of BMLC was made and treated with SLBZ-AP.

[Effects of socioeconomic factors on urban plant diversity of residential areas in Shanghai, China].

Residential area, usually consisting of buildings and vegetation, is one of the dominant land use types and an important kind of habitat in the urban area. Therefore, it plays an important role in urban biodiversity conservation. Previous studies found that plant diversity abroad in urban residential areas was influenced by socioeconomic factors.

[Gender-dependent expression of ERalpha in arsenic exposed mice offspring's lung tissue].

Objective: To observe theexpression variations of estrogen receptor alpha (ERalpha) in different periods of mice offspring and the gender-dependent differences in the lung tissue with parental arsenic exposure.

Methods: Parental female mice were exposed to arsenic by gavage from gestational day 8th to offspring infancy, and offspring were exposed to arsenic by drinking water after infancy. The expression level of ERalpha mRNA and protein in lung tissue of the male and female offspring in different developmental periods and different doses (low, middle, high) of sodium arsenite exposure were detected by real-time PCR and Western blot.