Synthesis of 2-Deoxyglycosides with Exclusive β-Configuration Using 2-SAc Glycosyl Bromide Donors.

In this study, we developed an indirect method for the synthesis of 2-deoxyglycosides with an exclusive β-configuration using glucosyl and galactosyl bromide donors with 2-thioacetyl (SAc) groups. The 2-SAc glucosyl and galactosyl bromide donors were easily obtained through the treatment of 1-OAc, 2-SAc glucose and galactose with HBr-CHCOOH solution, respectively. The glycosylation of such donors with acceptors under an improved Koenigs-Knorr condition resulted in glycosylation products with an exclusive β-configuration in excellent yields.

Highly Reactive Glycosylation with 1-(Methylthio)thiocarbonyl Glycosyl Donors under Acidic to Neutral Reaction Conditions.

In this study, we have successfully developed a glycosylation method using 1--(methylthio)thiocarbonyl-glycoses as donors. Such xanthate donors are easily accessible and shelf-stable. The glycosylation reaction could be promoted by cations (acidic to neutral conditions) under mild conditions, exhibiting a reactivity intermediate between that with glycosyl trichloroacetimidate as the donor and that with thioglycoside as the donor.

Integrative rehabilitation in the treatment of lumbosacral muscle strain in elite trampoline athletes: a pilot study.

Background: Lumbosacral muscle strain (LMS) is common in Chinese elite trampoline athletes. Advanced lumbar muscle activation is necessary for postural control before upper extremity voluntary movements, called anticipatory postural adjustment to reduce internal postural interference (IPI). The potential of delayed lumbar muscle activation has been reported in patients with non-specific LBP (NLBP) in response to IPI.

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation.

The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and transplantation (OTC-T), including the risk of tissue damage and dysfunction. Consequently, there has been a compelling exploration into the realm of nanoregulators to refine and enhance these procedures.

Meta-Analysis of Efficacy of Platelet-Rich Plasma Combined with Minoxidil for Androgenetic Alopecia.

Background: Androgenetic alopecia (AGA) is a prevalent type of hair loss that impacts individuals of both genders. Platelet-rich plasma (PRP) and minoxidil have been employed as therapeutic interventions for AGA, yet the efficacy of their concurrent use remains ambiguous.

Objective: To perform a comprehensive review and meta-analysis aimed at evaluating the effectiveness of platelet-rich plasma (PRP) in combination with minoxidil for the treatment of androgenetic alopecia (AGA).

Mechanism of static loading injury in human skeletal muscle cells.

Objective: To establish a cellular-level mechanical injury model for human skeletal muscle cells and investigate changes in the mechanical effect mechanism after such injuries.

Methods: The FX-5000™ Compression System was used to apply constant static mechanical pressure to human skeletal muscle cells. A factorial design analysis was conducted to discover the optimal injury model by evaluating the correlation between the amount of pressure, the duration of mechanical stimulation, and the number of days of observation.

Observation of the effect of angiojet to treat acute lower extremity arterial embolization.

Background: Through significant advances in the treatment of peripheral arterial occlusive disease, acute ischemia of the lower extremity is still associated with significant morbidity, limb threat and mortality. The two main causes of acute ischemia in lower extremities are arterial embolism and atherosclerotic arteries. Timely recognition and treatment of acute limb ischemia in emergency situations is essential in order to minimize the duration of ischemia.

Regenerative plantlets with improved agronomic characteristics caused by anther culture of tetraploid potato ( L.).

Objective: As the primary means of plant-induced haploid, anther culture is of great significance in quickly obtaining pure lines and significantly shortening the potato breeding cycle. Nevertheless, the methods of anther culture of tetraploid potato were still not well established.

Methods: In this study, 16 potato cultivars (lines) were used for anther culture .

Cardiac myxoma shedding leads to lower extremity arterial embolism: A case report.

Background: Left cardiac myxoma (CM) is the most common benign tumor of primary cardiac tumors, but because of its special position caused by pathological physiology change, caused by the complications of the heavier, the surface is often accompanied by blood clots, once fall out, it causes peripheral vascular embolization, such as acute lower limb artery embolization, harmfulness is large, high morbidity, and easy to occur repeatedly.

Case Summary: A 67-year-old male patient suddenly appeared numbness and weakness of the left lower limb and could not walk without obvious incentive. The patient was finally diagnosed as left CM complicated with acute lower limb arterial embolism after completing cardiac ultrasound, computer tomography angiography, and histopathological analysis, such as hematoxylin-eosin stain staining, immunohistochemistry and special staining including alcian blue staining and periodic acid schiff staining.

The mutation spectrum of Parkinson-disease-related genes in early-onset Parkinson's disease in ethnic Chinese.

Background And Purpose: Recent genetic progress has shown many causative/risk genes linked to Parkinson's disease (PD), mainly in patients of European ancestry. The study aimed to investigate the PD-related genes and determine the mutational spectrum of early-onset PD in ethnic Chinese.

Methods: In this study, whole-exome sequencing and/or gene dosage analysis were performed in 704 early-onset PD (EOPD) patients (onset age ≤45 years) and 1866 controls.

Functional Characterization of Two Antenna-Enriched Odorant-Binding Proteins From Bactrocera minax (Diptera: Tephritidae).

Olfaction is of great significance for insect mate-seeking and host-locating behaviors. Insect odorant-binding proteins (OBPs), especially those antenna-enriched OBPs, are thought to discriminate, capture and transport odorant molecules to olfactory receptors, but this has not been fully clarified in Bactrocera minax (Enderlein), an economically important pest of citrus crops. Our previous studies showed that seven OBP genes (BminOBP1-7) were identified from B.

Intermittent pressure imitating rolling manipulation ameliorates injury in skeletal muscle cells through oxidative stress and lipid metabolism signalling pathways.

Background: Traditional Chinese medicine manipulation (TCMM) is often used to treat human skeletal muscle injury, but its mechanism remains unclear due to difficulty standardizing and quantifying manipulation parameters.

Methods: Here, dexamethasone sodium phosphate (DSP) was utilized to induce human skeletal muscle cell (HSkMC) impairments. Cells in a three-dimensional environment were divided into the control normal group (CNG), control injured group (CIG) and rolling manipulation group (RMG).

[Formation Mechanism and Source Analysis of Two Heavy Pollution Periods in Winter in a Central Plains City].

To reveal the process and cause of air pollution in winter in Zhengzhou, Zhengfangji Station was selected as the sampling point to discuss the concentration of air pollutants and the characteristics of meteorological parameters in December 2019, in Zhengzhou. The concentration changes in PM water-soluble ions, elements, and carbon components in different pollution stages were compared, and air quality model simulation results were used to analyze emissions from pollution sources and regional transmission during sampling of the PM mass concentration at the sampling point. The results showed that there was a slight difference in the process of formation and dissipation of the first and second heavy pollution occurrences, showing the characteristics of "slow accumulation, slow removal" and "slow accumulation, fast removal", respectively.

Exohedral Cuprofullerene: Sequentially Expanding Metal Olefin Up to a C@Cu Rhombicuboctahedron.

Exohedral cuprofullerenes with 6-, 12-, or 24-nuclearity were obtained by utilizing fluorocarboxylic/dicarboxylic acid under solvothermal conditions. The 24-nuclear molecule presents a C@Cu core-shell structure with a rhombicuboctahedron Cu coated on the C core, representing the highest nuclearity in metallofullerene. The resultant complexes show an efficient absorption of visible light as opposed to the pristine C.

Coordination disk-type nano-Saturn complexes.

The first coordination disk-type nano-Saturn complexes, [Cu10(Mim)10]⊃C60 and [Cu10(Mim)10]⊃C70 (Mim = 2-methylimidazolate), were assembled under one-pot solvothermal conditions. The highest number of 30 C-Hπ interactions between the [Cu10(Mim)10] disk and the C60/C70 surfaces drives the formation of the nano-Saturns. The calculated interaction energy is much larger than that of most of the reported disk-type nano-Saturns.

Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review.

Background: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is characterized by spindle cells differentiated from muscle fibroblasts and infiltration of various types of inflammatory cells. IMT can occur at any age and at any anatomic site. The most common location of IMT is the bladder in the genitourinary tract.

White Light from Blue Fluorescence and Sensitized Yellow Long-Afterglow Phosphorescence of -Terphenyl in Its π-Acid···Base Adduct with AgPz.

White-light emission with CIE (0.32, 0.34) was realized for an -terphenyl (TP) molecule in its Ag[3,5-(CF)Pz] (Pz = pyrazolate) sandwiching adduct, originating from the hybrid of fluorescence and sensitized long-afterglow phosphorescence of TP.

A luminescent edge-interlocked prismatic heteroleptic metallocage assembled through a ligand replacement reaction.

A luminescent edge-interlocked heteroleptic metallocage based on Cu3(pyrazolate)3 was prepared through a ligand replacement reaction from a homoleptic metallocage and a new ligand. Its structure was confirmed by XRD and MALDI-TOF mass spectrometry. Theoretical calculations revealed the new ligand was evidently responsible for the bathochromic shift of the optimal excitation.

Solving flexible job shop scheduling problems with transportation time based on improved genetic algorithm.

In the practical production, after the completion of a job on a machine, it may be transported between the different machines. And, the transportation time may affect product quality in certain industries, such as steelmaking. However, the transportation times are commonly neglected in the literature.

Morphology and distribution of antennal sensilla of female Phyllotreta striolata (Fabricius) (Coleoptera: Chrysomelidae).

Phyllotreta striolata (Fabricius) is an important pest of Brassicaceae in Southeast Asia and North America. Using scanning electron microscopy, we observed the external structure, number, and distribution of the antennal sensilla in P. striolata females to discuss the putative function of these sensilla in host location and oviposition behaviors.

Unsupervised defect detection in textiles based on Fourier analysis and wavelet shrinkage.

An unsupervised approach for the inspection of defects in textiles by applying Fourier analysis and wavelet shrinkage is proposed. It does not rely on any reference images. For each sample under inspection, the periodic pattern in the background is first eliminated by zero-masking their dominant frequency components that show high gradient values in the spectrum.

A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury.

Background And Purpose: Ischaemic stroke is a serious disease with limited therapy options. Glycoprotein (GP)Ib binding to von Willebrand factor (vWF) exposed at vascular injury initiates platelet adhesion and contributes to platelet aggregation. GPIb has been suggested as an effective target for antithrombotic therapy in stroke.

[Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinoma A431 xenograft in nude mice].

Objective: To explore the anti-tumor effects of resveratrol (Res) upon human skin squamous cell carcinoma A431 xenograft in nude mice and elucidate the regulatory mechanisms of survivin and caspase-3.

Methods: The model of human skin squamous cell carcinoma (A431) xenograft in nude mice was established. And the animals were randomly divided into saline-negative control, cyclophosphamide (CTX) positive control, Res high-, medium- and low-dosage and blank control groups (n = 10 each).