An aquaporin and an aquaglyceroporin have roles in low temperature adaptation of mosquitoes (Anopheles sinensis).

Mosquitoes (Anopheles sinensis), widely geographically distributed in Asia including China, are the primary vector of the malaria parasite Plasmodium vivax and other parasitic diseases such as Malayan filariasis. An. sinensis can survive through low winter temperatures.

Mineralization Reduces the Toxicity and Improves Stability and Protective Immune Response Induced by .

Vaccination is an ideal strategy for the control and prevention of toxoplasmosis. However, the thermostability and effectiveness of vaccines limit their application. Here, calcium mineralization was used to fabricate tachyzoites as immunogenic core-shell particles with improved immune response and thermostability.

The complete mitochondrial genome of major malaria vector (Diptera: Culicidae) in China.

(Xu and Feng 1975) is the major vector of malaria in Eastern and Southern China. The species is considered a synonym of (Baisas & Hu, 1936), although they differ in several key biological characteristics. Here, we report the complete mitochondrial genome of for the first time.

Genetic Diversity Analysis of Surface-Related Antigen (SRA) in Imported From Africa to China.

surface-related antigen (SRA) is located on the surfaces of gametocyte and merozoite and has the structural and functional characteristics of potential targets for multistage vaccine development. However, little information is available regarding the genetic polymorphism of . To determine the extent of genetic variation about by characterizing the sequence, 74 samples were collected from migrant workers who returned to China from 12 countries of Africa between 2015 and 2019.

Research supporting malaria control and elimination in China over four decades: a bibliometric analysis of academic articles published in chinese from 1980 to 2019.

Background: China has accumulated considerable experience in malaria control and elimination over the past decades. Many research papers have been published in Chinese journals. This study intends to describe the development and experience of malaria control and elimination in China by quantitatively analysing relevant research using a bibliometric analysis.

Cost-effectiveness analysis of malaria rapid diagnostic test in the elimination setting.

Background: As more and more countries approaching the goal of malaria elimination, malaria rapid diagnostic tests (RDT) was recomendated to be a diagnostic strategy to achieve and maintain the statute of malaria free, as it's less requirments on equipment and experitise than microscopic examination. But there are very few economic evaluations to confirm whether RDT was cost-effective in the setting of malaria elimination. This research aimed to offer evidence for helping decision making on malaria diagnosis strategy.

Evaluating the implementation of rapid diagnostic tests in a malaria elimination setting.

Background: It was recommended that malaria rapid diagnostic tests (RDTs) should be available in all epidemiological situations. But evidence was limited on the implementation of RDTs and its effectiveness in malaria elimination settings. This study examined the implementation of RDTs and how it affected the diagnosis of imported malaria patients in Jiangsu Province, China.

Classification of induced malaria case in an elimination setting: investigation of transfusion-transmitted malaria cases.

Background: Since the National Malaria Elimination Action Plan was launched in China in 2010, local malaria transmission has decreased rapidly. Zero indigenous cases were reported since 2017. However, after 2010, the proportion of imported cases in China increased from 45.

Cost-effectiveness analysis of malaria rapid diagnostic tests: a systematic review.

Background: Rapid diagnostic tests (RDT) can effectively manage malaria cases and reduce excess costs brought by misdiagnosis. However, few studies have evaluated the economic value of this technology. The purpose of this study is to systematically review the economic value of RDT in malaria diagnosis.

[Epidemiological analysis of malaria prevalence in Jiangsu Province in 2017].

Objective: To understand the malaria epidemic situation and characteristics in Jiangsu Province in 2017, so as to provide the evidence for formulating the targeted strategy of malaria elimination.

Methods: The data of malaria cases in Jiangsu Province in 2016 were collected from China's Routine Diseases Surveillance Information System (CRDSIS).

Results: Totally, 239 imported malaria cases were reported in Jiangsu Province in 2017, and the cases decreased by 22.

[Progress and challenges of global malaria elimination].

Recently, the global malaria control has achieved remarkable results, and the epidemic map of malaria has gradually shrinked. However, in the past two years, the number of malaria deaths remained at a high level, and the incidence of malaria has even risen, leading to the stagnant of malaria elimination. The main reasons include lacking of the well monitoring and response system, sensitivity declining of antimalarial drugs, the spread of insecticide resistance, and the reduction of financial support.

[Results analysis of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017].

Objective: To analyze the results of samples testing of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017, so as to provide the evidence for improving the malaria diagnostic performance in this province.

Methods: The samples of reported malaria cases in Jiangsu were collected by the provincial reference laboratory (PRL) in 2017. The microscopy and nucleic acid test were performed to confirm the infection of species of each case, while antigen tests (rapid diagnostic test, RDT) were performed as well.

[Challenges for maintaining achievements of malaria elimination in Jiangsu Province, China].

Objective: To analyze the situation of malaria elimination, identify the current main challenges and difficulties of maintaining the achievements of malaria elimination, and find out feasible solutions in Jiangsu Province.

Methods: Through randomized grouping, the subject discussion and questionnaires were conducted by malaria control staffs from centers for diseases control and prevention of 13 cities of Jiangsu Province and Jiangsu Institute of Parasitic Diseases. The basic characteristics of participants and the effect of the discussion were analyzed through questionnaires.

[Construction and application of malaria biobank].

Objective: To establish a systemized malaria biobank with well-rounded epidemiologic data and a computer-aid management system, thus to provide qualified sources for malaria elimination and human malaria research.

Methods: The malaria biobank was based on the platform of Jiangsu Institute of Parasitic Diseases. The blood smear samples, dried blood samples, whole blood samples and parasite strains isolated from patients (from both local and imported cases) were collected since 2011 according to a standardized operational procedure.

[Vector surveillance in Jiangsu Province during the stage of malaria elimination].

Objective: To analyze the vector surveillance results during the stage of malaria elimination, so as to provide the evidence for assessing the local transmission risk of imported malaria and carrying out the surveillance work after malaria elimination in Jiangsu Province.

Methods: From 2011 to 2017, the mosquito population was monitored and human biting rates were calculated by the half overnight human baiting trapping method and overnight lamp trapping method in 7 surveillance sites from June to October. The insecticide resistance level was tested by the force contact method recommended by WHO.

[Evaluation of an optimization strategy for use and management of malaria rapid diagnostic testing (RDT) in Jiangsu Province].

Objective: To evaluate the implementation effect of the optimization strategy for the use and management of malaria rapid diagnostic testing (RDT) technology in Jiangsu Province, so as to provide the empirical evidence and suggestions for promoting the standardized use of RDT technology.

Methods: Questionnaire surveys of primary-level health professionals' RDT-related knowledge, attitude, and practice (KAP) and work satisfaction were conducted in 4 pilot cities in Jiangsu Province before and after the intervention.

Results: After the implementation of the intervention, 13.

[Investigation on malaria rapid diagnostic testing (RDT) - related knowledge, attitude and practice in primary healthcare professionals of Jiangsu Province].

Objective: To investigate the malaria rapid diagnostic testing (RDT) - related knowledge, attitude, practice (KAP) of primary healthcare professionals in Jiangsu Province and analyze the corresponding influencing factors.

Methods: Four cities in Jiangsu Province were selected as the study sites by the typical sampling method to conduct a survey for the RDT related KAP and work satisfaction of primary healthcare professionals, and the multiple logistic regression model was used to explore the relevant influencing factors.

Results: Totally 1 150 questionnaires were issued and 949 valid questionnaires were collected with the recovery rate of 82.

[Analysis of blood smear examination results of fever patients in Jiangsu Province from 2010 to 2016].

Objective: To analyze the working conditions and evaluate the effectiveness of blood smear examinations in fever patients after the start of national malaria elimination program (NMEP), and explore the suitable strategy for malaria diagnosis and surveillance in NMEP, so as to provide the evidence for the development and adaptation of malaria elimination strategies and measures in Jiangsu Province.

Methods: The data of malaria epidemic situation reported by network, fever patients' blood test tables, and epidemiological surveys of malaria cases were collected and statistically analyzed by SPSS 16.0 in Jiangsu Province from 2010 to 2016.

[Quality analysis of malaria microscopic examinations in Jiangsu Province from 2011 to 2017].

Objective: To understand the quality of production of blood slides and laboratory personnel's ability to microscopically examine at Jiangsu Province clinic inspection stations at all levels, so as to provide the evidence for the construction of malaria diagnostic laboratories and the evaluation of malaria elimination effect.

Methods: After the reexamination of the negative blood slides of the examination stations of the malaria center in each county (district), the negative blood slides of the outpatient inspection station in the district and all the positive blood slides of the direct report of the network from 2011 to 2017, the staining and cleanliness of the blood smears, microscopic examination results and the coincidence rate of positive blood species were comprehensively analyzed.

Results: A total of 19 109 checked blood samples were examined.

[Progress of malaria elimination of Jiangsu Province, China].

There were vivax malaria, falciparum malaria, and malariae malaria epidemic in Jiangsu Province, and vivax malaria was the dominant disease. and were malaria-transmitted vectors. Since the founding of People's Republic of China, there have been two major malaria outbreaks in Jiangsu Province, when the highest annual malaria incidence reached up to 24.

[Study on expression characteristics of cytochrome P450 genes in ].

Objective: To explore the expression characteristics of cytochrome P450 (CYP) candidate genes (CYP6M3, CYP6Y1, CYP6P5, CYP4H14, CYP4G17, CYP12F16) in .

Methods: The samples were collected from different developmental stages (eggs, larvae, pupae and adult mosquitoes (females and males) ), and different tissues (salivary glands, malpighian tubes, midguts, ovaries, and fat bodies) of and the female adult mosquitoes exposed by different insecticide doses (0, 1.25, 3.

[Epidemiological analysis of malaria prevalence in Jiangsu Province in 2016].

Objective: To understand the malaria epidemic situation and characteristics in Jiangsu Province in 2016, so as to provide the evidence for formulating and adjusting the strategy and measures for malaria elimination.

Methods: The data of malaria cases in Jiangsu Province in 2016 were collected from China's Routine Diseases Surveillance Information System (CRD-SIS) and analyzed statistically.

Results: Totally, 308 malaria cases were reported in Jiangsu Province in 2016, and the cases decreased by 23.

[Control of imported mosquito-borne diseases under the Belt and Road Initiative].

Mosquito is a vector of many infectious diseases, and it is recognized a leading killer of human in the world. After the Belt and Road Initiative launches, more are countries involved and the international communication and cooperation are significantly growing in China. Therefore, the risk of imported infectious diseases is increasing as well, some mosquito-borne diseases which have been well controlled or seldom seen in China, will be more risky to cause locally transmission from imported cases and become the threat to people's health in China.

[Establishment of malaria early warning system in Jiangsu Province Ⅷ Malaria vector monitoring in Jiangsu Province].

Objective: To understand the population, density, seasonal fluctuation and nocturnal pattern of malaria vectors in Jiangsu Province, thus to provide evidences for malaria elimination in this province.

Methods: Seven counties (cities, districts) were selected as the monitoring sites for malaria vectors in Jiangsu Province from 2013 to 2015. The mosquitoes were captured by human bait trapping in bed nets and mosquito-lured lamp overnight, and the seasonal fluctuation and nocturnal pattern of malaria vectors were observed.

[Analysis of channels of going abroad of imported malaria patients in Jiangsu Province, China].

Objective: To analyze the channels of going abroad of imported malaria patients in Jiangsu Province, so as to provide the evidence for the control of imported malaria and health intervention for high-risk population.

Methods: The data of imported malaria cases in Jiangsu Province in 2015 were collected and the channels of going abroad were analyzed. The Quantum GIS 1.