Quantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis.

There are some epidemiological studies investigating the association between interleukin-10 (IL-10) 1082A/G polymorphism and sepsis susceptibility reporting conflicting findings. Our work tried to further quantitatively assess the association of the IL-10 1082A/G polymorphism with sepsis susceptibility through a systematic review and meta-analysis. A total of eleven studies with 2,528 subjects were finally included into the meta-analysis.

Role of potassium channels in regulation of rat coronary arteriole tone.

Activity of potassium (K(+)) channels plays a key role in regulating arterial tone and therefore blood flow. But little is known about the roles of K(+) channels in the coronary arterioles. The aim of the present study was to investigate the influences of several potassium channel blockers on resting vascular tone in isolated rat coronary arteriole.

Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.

Salvia miltiorrhiza has been widely used in the treatment of various cardiovascular diseases due to its ability to improve coronary microcirculation and increase coronary blood flow. Tanshinone II(A), the major active lipophilic ingredient responsible for the beneficial actions of Salvia miltiorrhiza, was shown to induce vasodilation in coronary arteries. But its effects on coronary arterioles remain unknown.