Publications by authors named "Guo-Zhong Tong"
Article Synopsis
- A new series of 7-substituted [1,2,4]triazolo[4,3-f]pyrimidine derivatives were created to explore their potential as anticonvulsant drugs.
- The compound 3i was identified as the most effective in the study with a median effective dose of 34.7 mg/kg and a protective index of 7.6, indicating it has a favorable safety profile.
- Additionally, compound 3i successfully reduced seizures caused by various triggers while demonstrating low oral neurotoxicity.
Two erythrodiol triterpene fatty esters, 3beta-dodecanoyl erythrodiol (1) and 3beta-tetradecanoyl erythrodiol (2), were isolated from Scorzonera mongolica. Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound.
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