Publications by authors named "Guo-Yan Sui"
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme involved in the conversion of cortisone to active cortisol in the liver. Elevated cortisol levels can trigger oxidative stress, inflammation, and hepatocyte damage, highlighting the importance of 11β-HSD1 inhibition as a potential therapeutic approach. This study aimed to explore the effects of INU-101, an inhibitor of 11β-HSD1, on the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis.
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- The combined use of alcohol and cocaine leads to more significant and unpredictable liver, heart, and brain damage compared to using either substance alone.
- Research involving marmosets and mice demonstrated that using both substances together caused worse liver injury and inflammation than individual use did.
- The study identifies hippuric acid as a critical metabolite linked to increased liver damage through inflammation pathways, suggesting that targeting the HA-STING-TNFR1 signaling axis could be a promising treatment for alcohol- and cocaine-related liver injuries.
Article Synopsis
- Mitochondria are crucial for the immune system's stability and are significantly involved in inflammatory bowel disease (IBD) and colorectal cancer (CRC).
- When mitochondrial function is impaired in the gut, it can trigger overactive inflammatory responses, worsening these diseases.
- This review examines the connection between mitochondrial health, inflammatory pathways, and their impact on gastrointestinal diseases.