Exosomes from artesunate-treated bone marrow-derived mesenchymal stem cells transferring to promote osteogenesis via TAF15-RUNX2 pathway.

Effect of artesunate (ART)-treated bone marrow-derived mesenchymal stem cells-derived exosomes (BMSC-Exos) on osteogenesis and its underlying mechanisms were investigated. Proliferation, alkaline phosphatase activity and calcified nodule formation of osteoblasts were determined. A mouse model of osteoporosis was established by ovariectomy.