[Association Analysis between Genotype and Phenotype of α,β-Thalassaemia Carriers in Huizhou Area of Guangdong Province].

Objective: To analyze the prevalence, genotype distribution and hematological characteristics of α,β-thalassaemia carriers in Huizhou area of Guangdong Province.

Methods: 10 809 carriers of simple β-thalassaemia and 1 757 carriers of α,β-thalassaemia were enrolled as our study cohort. The hematological parameters were detected by automated blood cell counters and automatic capillary electrophoresis.

Genetic counseling and prenatal decision for hemoglobin H disease caused by the rare α2 codon 30 (-GAG) (HBA2: c.91_93delGAG) mutation and the SEA deletion: Case series study.

Objective: We report a rare mutation on the α2-globin gene, HBA2: c.91_93delGAG and its potential functions.

Case Report: We mainly described four patients with hemoglobin (Hb) H disease caused by the rare mutation and the SEA deletion but diversity in clinical presentation.

Significantly inhibitory effects of low molecular weight heparin (Fraxiparine) on the motility of lung cancer cells and its related mechanism.

Low molecular weight heparin (LMWH) improving the cancer survival has been attracting attention for many years. Our previous study found that LMWH (Fraxiparine) strongly downregulated the invasive, migratory, and adhesive ability of human lung adenocarcinoma A549 cells. Here, we aimed to further identify the antitumor effects and possible mechanisms of Fraxiparine on A549 cells and human highly metastatic lung cancer 95D cells.

Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells.

Background: Gene therapy has tremendous potential for both inherited and acquired diseases. However, delivery problems limited their clinical application, and new gene delivery vehicles with low cytotoxicity and high transfection efficiency are greatly required.

Methods: In this report, we designed and synthesized three amphiphilic molecules (L1-L3) with the structures involving 1, 4, 7, 10-tetraazacyclododecane (cyclen), imidazolium and a hydrophobic dodecyl chain.

Synthesis and cofluorescence of Eu(Y) complexes with salicylic acid and o-phenanthroline.

A series of dinuclear complexes of salicylic acid (HSal) and o-phenanthroline (Phen) with different molar ratios of Eu3+ to Y3+ have been synthesized. Their compositions are Eu(x)Y(1-x) (Sal)3(Phen) (x = 0 to approximately 1). Their UV spectra, IR spectra, and fluorescence spectra were studied.

Sintering and microstructure of silicon carbide ceramic with Y3Al5O12 added by sol-gel method.

Silicon carbide (SiC) ceramic with YAG (Y3Al5O12) additive added by sol-gel method was liquid-phase sintered at different sintering temperatures, and the sintering mechanism and microstructural characteristics of resulting silicon carbide ceramics were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and elemental distribution of surface (EDS). YAG (yttrium aluminum garnet) phase formed before the sintering and its uniform distribution in the SiC/YAG composite powder decreased the sintering temperature and improved the densification of SiC ceramic. The suitable sintering temperature was 1860 degrees C with the specimen sintered at this temperature having superior sintering and mechanical properties, smaller crystal size and fewer microstructure defects.

Investigation of compaction and sintering behavior of SiC powder after ultra-fine treatment.

Silicon carbide ceramics were prepared with SiC powder treated by the fluidized bed opposed jet mill as raw materials, and the effects of the ultra-fine treatment mechanism on the compaction and sintering behavior of SiC ceramics were investigated. The results showed that the compacts had higher density and microstructure homogeneity when the sintering temperature of the compact was decreased; and that the surface microstructure, densification and mechanical properties of the sintered body could be ameliorated obviously.