Publications by authors named "Guo-Wei Bu"
Article Synopsis
- - Oocytes, the biggest cells in multicellular animals, rely on mRNA transporter 4 (MTR4) for their growth and proper functioning, as MTR4 is crucial for clearing out defective RNA from the nucleus.
- - MTR4 supports the processing and export of maternal RNAs, and when it's knocked out, oocytes fail to gather enough healthy transcripts, leading to abnormal growth.
- - Additionally, MTR4 helps maintain a stable nuclear environment essential for specific biochemical modifications that contribute to oocyte development, thus playing a key role in ensuring they mature correctly and are ready for further development.
Nuclear transfer embryonic stem cells (ntESCs) hold enormous promise for individual-specific regenerative medicine. However, the chromatin states of ntESCs remain poorly characterized. In this study, we employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and three-dimensional (3D) genome organization of ntESCs.
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