Publications by authors named "Guo-Shuai Xu"
Article Synopsis
- - The serrated pathway to colorectal cancers (CRCs) involves five types of lesions: hyperplastic polyps, sessile serrated lesions, sessile serrated lesions with dysplasia, traditional serrated adenomas, and unclassified serrated adenomas, each playing different roles in cancer development.
- - This pathway diverges from the conventional adenoma-carcinoma pathway, primarily involving mutations (BRAF/KRAS) and a specific methylation pattern (CIMP) that are crucial for understanding CRC progression.
- - Effective management requires distinguishing these lesions via histological and colonoscopic evaluation, with recommendations for timely removal of premalignant lesions and ongoing surveillance to improve colorectal cancer screening outcomes.
[Expressions of Sry-related High Mobility Group Box 9 and Gastrokine-1 in Gastric Cancer and Their Relationships with Prognosis].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
June 2019
Objective To explore the expressions of Sry-related high mobility group box 9(SOX9)and gastrokine-1(GKN1) in gastric cancer tissues and their relationships with clinicopathologic features and prognosis of patients.Methods Immunohistochemistry was used to detect the expressions of SOX9 and GKN1 in 70 cases of gastric cancer tissues and corresponding paracancerous tissues including 27 cases of intestinal metaplasia and 43 cases of normal gastric mucosa. The relationships of SOX9 and GKN1 expressions with clinicopathological features and prognosis were analyzed in gastric cancer tissues.
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