Simultaneously enhancing the crystallization rate and fire retardancy of poly(lactic acid) by using a novel bifunctional additive trimethylamine phenylphosphonate.

Simultaneously regulating the crystallizing and combustion behaviors of poly(lactic acid) (PLA) will be conducive to its further development in the fields of electronic appliances, automotive and rail transit materials. To achieve this goal, a novel bifunctional additive triethylamine phenylphosphonate (TEAP) was synthesized through acid-base neutralization reaction between trimethylamine and phenylphosphonic acid. When TEAP was added into PLA, the crystallization behaviors of PLA/TEAP assessed by differential scanning calorimetry (DSC) and polarized optical microscopy (POM) suggested that TEAP acted as a nucleating agent and plasticizer for PLA, which effectively increased the crystallization rate of PLA.

[Reappraisals of mental disabilities due to traffic accidents: a retrospective analysis of 51 cases].

Objective: To discuss the causes for changes of opinions in reappraisals of mental disabilities due to traffic accidents.

Methods: Fifty-one reappraisals of mental disorders due to traffic accidents from October 2009 to October 2011 in the Institute of Forensic Science, Shaoxing Seventh People's Hospital, were retrospectively analyzed.

Results: In the reappraisals, the opinions about disability grade changed in 30 cases (58.

[Study on efficacy of zaoren anshen capsules in treating senile insomnia and changes in its hemorheology].

Objective: To observe the effect of Zaoren Anshen capsules in treating senile insomnia and changes in its hemorheology.

Method: A total of 120 patients with senile insomnia were randomly divided into the Zaoren Anshen capsules group (five capsules, n = 60) and the Alprazolam group (0.8 mg, n = 60) for treatment and control observation.

γ-Oxygenation of α,β-unsaturated esters by vinylogous O-nitroso Mukaiyama aldol reaction.

A practical procedure has been developed for γ-oxygenation of α,β-unsaturated esters by a vinylogous O-nitroso Mukaiyama aldol reaction followed by a one-pot N-O bond heterolysis of the in situ generated γ-aminoxy-α,β-unsaturated esters.

Diastereoselective synthesis of syn-1,3-diols by titanium-mediated reductive coupling of propargylic alcohols.

A titanium-mediated, hydroxy-directed reductive coupling reaction of propargylic alcohols and aldehydes/ketones is described. Excellent diastereoselectivity and synthetically useful yields have been obtained for a range of substrates. This transformation has enabled a highly convergent three-component approach to syn-1,3-diols using (trimethylsilyl)acetylene as a C1 linchpin.

Stereoselective synthesis of bioactive isosteviol derivatives as alpha-glucosidase inhibitors.

Considerable interest has been attracted in isosteviol and its derivatives because of their large variety of pharmacological activities. In this project, a series of novel compounds containing hydroxyl, hydroxymethyl group and heteroatom-containing frameworks fused with isosteviol structure were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these isosteviol derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities.

Palladium(II)-catalyzed ring enlargement of 2-(arylmethylene)cyclopropylcarbinols: strong effect of substituent electronic nature on the reaction pathway.

In the presence of Pd(II) catalyst and copper(II) bromide, 2-(arylmethylene)cyclopropylcarbinols undergo ring enlargement to deliver (arylcyclobutenyl)carbinols or hydrogenated furans in good yields under mild conditions; mechanisms accounting for the distinct products have been proposed on the basis of control and deuterium labeling experiments.

Thermal rearrangement of {[2-(Arylmethylene)cyclopropyl]methyl}(phenyl)sulfanes and selanes.

{[2-(Arylmethylene)cyclopropyl]methyl}(phenyl)sulfanes and {[2-(arylmethylene)cyclopropyl]methyl}(phenyl)selanes, generated in situ from 2-(arylmethylene)cyclopropylcarbinols with sodium benzenethiolate and sodium benzeneselenolate, could undergo rearrangement upon heating to afford (2-arylmethylidenebut-3-enyl)(phenyl)sulfanes and (2-arylmethylidenebut-3-enyl)(phenyl)selanes, in good to excellent yields as mixtures of E- and Z-isomers, respectively. A radical rearrangement was proposed on the basis of control experiments for this process.

Gold(I)-catalyzed three-component additions of 2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols: an efficient access to 3-oxabicyclo[3.1.0]hexanes.

Catalyzed by gold(I), (E)- and (Z)-2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols underwent three-component addition reactions to produce 3-oxabicyclo[3.1.0]hexanes in high yields and moderate diastereoselectivities under mild conditions.

Brønsted acid-mediated stereoselective cascade construction of functionalized tetrahydropyrans from 2-(arylmethylene)cyclopropylcarbinols and aldehydes.

(E)- and (Z)-2-(Arylmethylene)cyclopropylcarbinols 1 could be converted to the corresponding tetrahydropyrans 2 and 3 stereoselectively in the presence of Brønsted acids MsOH or TsOH under mild conditions. A plausible Prins-type reaction mechanism has been proposed.