Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.

Background: Non-alcoholic fatty liver disease (NAFLD) is correlated with obesity, but specific therapeutic interventions are lacking. Adiponectin is an adipokine with anti-inflammatory activity and is considered a hepatic protector. We aimed to investigate effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.

Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease.

Aim: To explore the therapeutic role of globular adiponectin (gAd) in high-fat diet/streptozotocin (STZ)-induced type 2 diabetic rats with nonalcoholic fatty liver disease (NAFLD).

Methods: Seven rats were fed a basic diet (normal control group; NC) during the experiment. Experimental rats (14 rats) were given a high-fat diet for 4 wk and were then injected with STZ to induce type 2 diabetes mellitus (T2DM) and NAFLD.

A novel role of globular adiponectin in treatment with HFD/STZ induced T2DM combined with NAFLD rats.

Aims: To evaluate the effects of globular adiponectin (gAd) on treatment of type 2 diabetic rats combined with NAFLD.

Materials And Methods: Twenty-one male wistar rats were fed with normal diet (7 rats) or high fat diet (HFD) (14 rats) for 4 weeks, and then HFD-fed rats were injected with streptozotocin (STZ) to induce type 2 diabetes mellitus (T2DM). Half of T2DM rats were randomly injected with gAd intraperitoneally for 7 days.