Hybrid of dehydroergosterol and nitrogenous alternariol derivative from the fungus Pestalotiopsis uvicola.

A new hybrid of dehydroergosterol and nitrogenous alternariol derivative, pestauvicomorpholine A (1), and three alternariol analogues (2-4) including a new aminated one, pestauvicolactone A (2), were isolated from the fermentation product of the fungus Pestalotiopsis uvicola on rice media. Compounds 1 and 2 represent the first example of aza-alternariol and aza-alternariol-steroid derived from transamination followed by intermolecular hetero-Diels-Alder reaction.

Three new polyketides from sp. ZJ-M-5 by the OSMAC strategy.

Three new compounds, ascotrichols A-B () and ascotrichrone A (), along with two known isocoumarin derivatives (), were isolated from the solid culture of a sea mud-derived fungus, sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations were determined by electronic circular dichroism and biogenetic correlation.