Publications by authors named "Guo-Kai Dong"
Progranulin (PGRN) is a multi-functional growth factor known to be involved in regulating of development, cell cycle progression, cell motility, tumorigenesis and angiogenesis. Research has revealed that PGRN is a crucial mediator of skin wound healing. Nonetheless, the role of PGRN in the fibrosis process of cutaneous wound healing has not been identified.
View Article and Find Full Text PDFGene expression profile of human esophageal squamous carcinoma cell line TE-1.
Int J Clin Exp Med
November 2015
Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) is a major global health issue, but its underlying mechanisms are not fully understood.
- This study analyzed the gene expression profiles of the TE-1 esophageal cancer cell line compared to normal HET-1A cells, identifying nearly 5,000 differentially expressed RNA transcripts.
- Further bioinformatics analysis linked these transcripts to important signaling pathways, such as p53 and mTOR, which could inform future prevention and treatment strategies for esophageal cancer.
Objective: To observe the expression pattern of caspase-3 and HCLS1-associated protein X-1 (HAX-1) at different time after cerebral contusion in rat, and explore the new method for estimating the injury interval.
Methods: The cerebral contusion model was established using adult SD male rats. Then the rats were randomly allocated into 8 groups: 2 h, 6 h, 12 h, 1 d, 3 d, and 7 d after cerebral contusion, sham-operation and normal control.
Objective: To explore the effect of nitric oxide (NO) on the gene expression of hepatic TNF-α and IL-1β by crush injury of rat's soft tissues.
Methods: Rats were randomly divided into sham group, crush group, crush+aminoguanidine (AG) group, and crush+L-arginine (L-Arg) group. Activities of ALT and AST as well as NO level in serum were measured.
The objective of the present study was to investigate the expression of paxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues, and their relationship with clinicopathological parameters, as well as to analyze the correlation of paxillin and FAK mRNA levels in esophageal carcinoma. By using reverse transcription polymerase chain reaction (RT-PCR), the mRNA expression levels of paxillin and FAK were detected in 121 samples of esophageal carcinoma, 43 samples of atypical hyperplasia and 56 samples of normal esophageal mucosa. The results showed that the positive rates of paxillin and FAK mRNA expression in esophageal carcinoma were 87.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to examine how caspase-3 and iNOS levels change over time after brain injuries in humans to help estimate the timing of these injuries.
- Thirty individuals who died from severe brain injuries were analyzed against a control group of five non-brain injury cases using immunohistochemistry.
- Results showed that caspase-3 levels increased significantly within 2 hours post-injury, remained elevated for several days, while iNOS levels started rising after 4 hours and peaked at 1-2 days before declining, indicating both markers can aid in assessing injury timing.