Publications by authors named "Guo-Jun Hou"
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC.
View Article and Find Full Text PDFBackground: At present, the first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC) is gemcitabine combined with cisplatin, but a considerable portion of ICC patients exhibit resistance to gemcitabine. Therefore, finding sensitisers for gemcitabine chemotherapy in ICC patients and predicting molecular markers for chemotherapy efficacy have become urgent needs.
Methods: In this study, PDX models were established to conduct gemcitabine susceptibility tests.
Background: Sleep quality has been always an important problem for patients after hepatectomy. The main purpose of the study is to investigate the effects of early ambulation on sleep quality in patients after liver resection a quantitative study.
Methods: Patients undergoing liver tumor resection were randomly divided into two groups, and the Pittsburgh Sleep Quality Index (PSQI) was used to assess the postoperative activities and sleep quality.
We previously demonstrated that interleukin-17A (IL-17A) is associated with the progression of hepatocellular carcinoma (HCC). However, its role in the invasion-metastasis cascade of HCC and the efficacy of IL-17A-targeting therapeutics in HCC remain largely unknown. In this study, we found that IL-17A promoted intrahepatic and pulmonary metastasesis of HCC cells in an orthotopic implant model.
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- Researchers are investigating ways to enhance liver regeneration while reducing the risk of liver cancer, particularly focusing on a protein named Nuclear receptor corepressor 1 (NCoR1).
- In a study with mice lacking the NCoR1 protein, liver regeneration significantly improved after surgery, and the cancer process was halted after chemical exposure.
- The findings suggest that NCoR1 negatively regulates fat synthesis in the liver and affects energy production, highlighting its different impacts on liver recovery and cancer development.
Signal transducer and activator of transcription 3 (STAT3) promotes tumor progression in many types of cancer. In this study, we analyzed the prognostic value of this marker in human intrahepatic cholangiocarcinoma (ICC). Using real-time PCR, western blot and immunohistochemistry assays, we found that STAT3 is overexpressed in ICC patients.
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- * The virus tends to integrate into fragile areas and specific functional regions like CpG islands, with different patterns observed between tumor and non-tumor tissues, particularly near telomeres in tumors.
- * Males show a higher frequency of HBV integration than females, especially on chromosome 17, and distinct patterns are influenced by the presence of cirrhosis, indicating that HBV integration can significantly contribute to the development of cancer.