Publications by authors named "Guo-Hu Hong"
T cells play critical roles in the progression of tuberculosis (TB); however, knowledge regarding these molecular mechanisms remains inadequate. This study constructed a critical ceRNA network was constructed to identify the potentially important role of TB activation T-cell regulation. We performed integrated bioinformatics analysis in a randomly selected training set from the GSE37250 dataset.
View Article and Find Full Text PDF[The velocity of HCV subtype 6a transmission in southwest China].
Zhonghua Gan Zang Bing Za Zhi
July 2011
Objective: To estimate the velocity of HCV subtype 6a transmission in Southwest China.
Methods: The HCV CE1 region from 61 patients infected with HCV genotype 6 were amplificated by RT-PCR and sequenced. The subtypes were identified, and the period of HCV 6a strains originated in southwest china was estimated by using molecular clock phylogenetic analysis.
[Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV core protein].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
April 2011
Objective: To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes.
Methods: Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein.
Results: There were diversities in secondary structure and tertiary structure of different genotypes.
Article Synopsis
- This study investigates the prevalence of natural recombinants of hepatitis C virus (HCV) in southwest China, focusing on both intragenotypic and intergenotypic types to understand their occurrence in the region.
- Researchers analyzed 243 serum samples from various patients, including drug users and those on hemodialysis, and found that while multitypic HCV infections were common, the actual recombination of HCV strains was rare.
- The conclusion indicates that despite a high rate of multitypic infections among patients with multiple HCV exposures, the rates of HCV recombination are low, suggesting that routine advanced genotyping may not be necessary for clinical practices in this area.