[Effect of dimethoate on serum monoamines neurotransmitters in rats].

Objective: To study the effect of dimethoate on the monoamine Neurotransmitters, including norepinephrine (NE), epinephrine (E), serotonin (5-HT), dopamine (DA) and its metabolite (3, 4-hydroxyphenylacetic acid, DOPAC) in the serum of rats and furthermore to explore the non-cholinergic mechanism of organophosphate induced toxicity.

Methods: Groups of rats were treated with saline and 38.9, 83.

[Study on monoamine neurotransmitters in rat serum and brain tissue by high performance liquid chromatography with electrochemical detection].

Objective: A rapid, reliable and simple method detecting monoamine neurotransmitters in rat serum and brain tissue by high performance liquid chromatography with electrochemical detector was developed.

Methods: An ODS column was selected as separation column at room temperature,and the mobile phase (pH4.50) consisted of 0.