Publications by authors named "Guo-Guo Chu"
[Mechanism of bilobalide promoting neuroprotection of macrophages].
Zhongguo Zhong Yao Za Zhi
August 2023
This study aims to explore the neuroprotective effect of bilobalide(BB) and the mechanisms such as inhibiting inflammatory response in macrophage/microglia, promoting neurotrophic factor secretion, and interfering with the activation and differentiation of peripheral CD4~+ T cells. BB of different concentration(12.5, 25, 50, 100 μg·mL~(-1)) was used to treat the RAW264.
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- Multiple sclerosis (MS) is a complicated central nervous system disease characterized by demyelination and inflammation.
- Hydroxyfasudil, a metabolite of Fasudil, has shown promise in alleviating symptoms and pathological damage in an animal model of MS (EAE), while also reducing immune cell infiltration.
- The treatment led to a favorable shift in T cell balance, promoted anti-inflammatory responses, and suggested protective effects on the blood-brain barrier, indicating its potential as a new therapy for MS.
Multiple sclerosis (MS) is mainly associated with the neuroinflammation and demyelination in the central nervous system (CNS), in which the failure of remyelination results in persistent neurological dysfunction. Fasudil, a typical Rho kinase inhibitor, has been exhibited beneficial effects on several models of neurodegenerative disorders. In this study, we showed that Fasudil promoted the uptake of myelin debris by microglia via cell experiments and through a cuprizone (CPZ)-induced demyelinating model.
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