Publications by authors named "Guo-Gang Liang"
Article Synopsis
- * Low concentrations of HS were found to enhance EGC function by increasing mitochondrial membrane potential, reducing apoptosis markers (BAX and caspase-3), and promoting cell proliferation, while high concentrations had detrimental effects.
- * Honokiol treatment provided protective benefits to EGCs under high HS conditions by modulating apoptosis and improving calcium response, ultimately supporting colonic motility through the Bcl2/BAX/caspase-3 pathway and Cx43 expression.
Article Synopsis
- Artemisinin (ART) and its derivatives are known for their antimalarial and emerging anticancer properties, while ruthenium complexes have shown potential as cancer treatments.
- A new compound, ruthenium-dihydroartemisinin complex (D-Ru), was developed to enhance the anticancer and anti-inflammatory effects of ART specifically for colorectal cancer (CRC) management.
- D-Ru demonstrated stronger cancer cell growth inhibition and induced cell cycle arrest, apoptosis, and regulation of immune responses compared to ART alone, indicating significant therapeutic potential.
Background: Gastroparesis is a syndrome characterized by delayed gastric emptying with associated symptoms. It was reported that the symptoms of diabetic gastroparesis had been greatly improved by transpyloric stent placement. However, the use of stents in benign conditions is considered to be contraindicated because of the increasing risk of complications, such as stent migration, reflux, perforation, bleeding, and, most importantly, new strictures caused by stent-induced tissue hyperplasia.
View Article and Find Full Text PDFObjective: To observe the effects of Dachengqi Decoction (大承气汤, DCQD) on morphological changes in the network of enteric nerve-interstitial cells of Cajal (ICCs)-smooth muscle cells (SMC) of enteric deep muscular plexuses (DMP) in the rats with multiple organ dysfunction syndrome (MODS).
Methods: One hundred Wistar rats of both sexes weighing 200 to 250 g were randomly divided into the control group, MODS group, and DCQD group. The morphologic changes of enteric nerve-ICC-SMC network in the DMP of intestine was observed using c-Kit and vesicular acetylcholine transporter/neuronal nitric oxide synthase immunohistochemical double-staining with whole-mount preparation technique, confocal laser scanning microscopy, and electron microscopy.
In order to examine the effects of Da-Cheng-Qi-Tang (DCQT) on gastrointestinal motility functions after abdominal surgery in humans, 33 patients with abdominal surgeries and 36 patients with cholecystectomies were divided into the DCQT and the control groups at random. Electrogastrography (EGG) and gastroduodenojejunal manometry was performed and the levels of plasma motilin were measured by radioimmunoassay. The results were as follows: (1) on the day of surgery, the ratio of EGG normal frequency in the DCQT group was higher than in the control group (P=0.
View Article and Find Full Text PDF[Determination of cirsilineol in Herba Artemisiae scopariae collected in autumn by HPLC].
Zhongguo Zhong Yao Za Zhi
January 2002
Objective: To establish a quantitative method for determination of cirsilineol in Herba Artemisiae Scopariae collected in Autumn.
Method: Sample was extracted with methanol, and cleaned up with polyamide column. ODS column was used with methanol-acetonitrile-0.