Publications by authors named "Guo-Fang Xie"
Article Synopsis
- Superoxide dismutase 1 (SOD1) is a critical antioxidant and its serum levels are linked to the severity and prognosis in community-acquired pneumonia (CAP) patients.
- A study conducted on CAP patients found that higher serum SOD1 levels correlate with more severe disease and worse outcomes, such as increased ICU admissions and longer hospital stays.
- The findings suggest that measuring serum SOD1 can serve as a valuable biomarker for assessing both the severity and potential outcomes of CAP in patients.
Article Synopsis
- PPARγ is a nuclear receptor highly expressed in the lungs, with its endogenous ligand being 15d-PGJ2, but their roles in COPD were previously unclear.
- In the study, serum levels of 15d-PGJ2 were found to be lower in COPD patients compared to healthy controls, and higher levels of 15d-PGJ2 were linked to better lung function.
- Additionally, COPD patients exhibited reduced PPARγ-positive nuclei and increased oxidative stress indicators, indicating a negative relationship between oxidative stress and both serum 15d-PGJ2 and PPARγ levels.
Background: S100A4 is a member of the S100 calcium-binding protein family and is increased in patients with chronic obstructive pulmonary disease (COPD). Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid, which regulates the adhesion between the cells and the extracellular matrix and affects cell migration and differentiation. The goal of this study was to analyze the correlations among S100A4, S1P, and pulmonary function among COPD patients.
View Article and Find Full Text PDFEnvironmental cadmium (Cd) exposure can cause several pulmonary diseases. Epithelial-mesenchymal transition (EMT) involved in the process of chronic obstructive pulmonary disease (COPD). However, the association between environmental Cd exposure and EMT was unclear in COPD patients.
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